The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes
The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes
Dokument öffnen (1.7MB)Datum der Veröffentlichung
12.10.2020Verlag / herausgebende Einrichtung
de GruyterVerlagsort
BerlinMetadaten
Zur Langanzeige
Zitierbarer Link (Handle URI) 
https://hdl.handle.net/20.500.11811/11476
Inhalt
DHX36 is a member of the DExD/H box helicasefamily, which comprises a large number of proteinsinvolved in various cellular functions. Recently, thefunction of DHX36 in the regulation of G-quadruplexes(G4s) was demonstrated. G4s are alternative nucleic acidstructures, which influence many cellular pathways on atranscriptional and post-transcriptional level. In thisreview we provide an overview of the current knowledgeabout DHX36 structure, substrate specificity, andmechanism of action based on the available models andcrystal structures. Moreover, we outline its multiplefunctions in cellular homeostasis, immunity, and disease.Finally, we discuss the open questions and providepotential directions for future research.
Schlagwörter
immunity, transcription, translation
Klassifikation (DDC)
540 Chemie 570 Biowissenschaften, Biologie 610 Medizin, GesundheitErschienen in
Biological Chemistry, 2021, vol. 402, no. 5, S. 581-591Erstpublikation
https://doi.org/10.1515/hsz-2020-0292Schult, Philipp; Paeschke, Katrin: The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes. In: Biological Chemistry. 2021, vol. 402, no. 5, 581-591.
Online-Ausgabe in bonndoc: https://hdl.handle.net/20.500.11811/11476
Online-Ausgabe in bonndoc: https://hdl.handle.net/20.500.11811/11476
@article{handle:20.500.11811/11476,
author = {{Philipp Schult} and {Katrin Paeschke}},
title = {The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes},
publisher = {de Gruyter},
year = 2020,
month = oct,
journal = {Biological Chemistry},
volume = 2021, vol. 402,
number = no. 5,
pages = 581--591,
note = {DHX36 is a member of the DExD/H box helicasefamily, which comprises a large number of proteinsinvolved in various cellular functions. Recently, thefunction of DHX36 in the regulation of G-quadruplexes(G4s) was demonstrated. G4s are alternative nucleic acidstructures, which influence many cellular pathways on atranscriptional and post-transcriptional level. In thisreview we provide an overview of the current knowledgeabout DHX36 structure, substrate specificity, andmechanism of action based on the available models andcrystal structures. Moreover, we outline its multiplefunctions in cellular homeostasis, immunity, and disease.Finally, we discuss the open questions and providepotential directions for future research.},
url = {https://hdl.handle.net/20.500.11811/11476}
}
author = {{Philipp Schult} and {Katrin Paeschke}},
title = {The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes},
publisher = {de Gruyter},
year = 2020,
month = oct,
journal = {Biological Chemistry},
volume = 2021, vol. 402,
number = no. 5,
pages = 581--591,
note = {DHX36 is a member of the DExD/H box helicasefamily, which comprises a large number of proteinsinvolved in various cellular functions. Recently, thefunction of DHX36 in the regulation of G-quadruplexes(G4s) was demonstrated. G4s are alternative nucleic acidstructures, which influence many cellular pathways on atranscriptional and post-transcriptional level. In thisreview we provide an overview of the current knowledgeabout DHX36 structure, substrate specificity, andmechanism of action based on the available models andcrystal structures. Moreover, we outline its multiplefunctions in cellular homeostasis, immunity, and disease.Finally, we discuss the open questions and providepotential directions for future research.},
url = {https://hdl.handle.net/20.500.11811/11476}
}
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