Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres
Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres
View/Date of Publication
01.05.2012Publisher
Bentham Science Publ.Publisher Location
HilversumMetadata
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Citable Link (Handle URI) 
https://hdl.handle.net/20.500.11811/11478
Abstract
DNA and RNA regions containing tracts of guanines can form very stable secondary structures called G-quadruplex (G4). Genomic sequences with the potential to form G4 (G4-motifs) are abundant across species. In all analyzed genomes G4 motifs are found near promoter regions and double strand break sites and at telomeres. Telomeres are very G-rich and prone for G4 formation. Therefore they are routinely used in in vitro and in vivo experiments to elucidate the function of G4 structures in telomere metabolism. Recently various labs demonstrated that telomere length maintenance is mediated via G4 structures. Telomere-binding proteins specifically bind to G4 structure and regulate this structure throughout the cell cycle.
Subjects
Ciliate, helicase, higher-order DNA structure, telomere-binding protein
Classification (DDC)
570 Biowissenschaften, Biologie 610 Medizin, GesundheitPublished in
Current pharmaceutical design, 2012, vol. 18, iss. 14, pp. 1867-1872First Publication
https://doi.org/10.2174/138161212799958404Stefan, A. Juranek; Katrin, Paeschke: Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres. Hilversum: Bentham Science Publ., 2012. In: Current pharmaceutical design. 2012, vol. 18, iss. 14, 1867-1872.
Online-Ausgabe in bonndoc: https://hdl.handle.net/20.500.11811/11478
Online-Ausgabe in bonndoc: https://hdl.handle.net/20.500.11811/11478
@misc{handle:20.500.11811/11478,
author = {{A. Juranek Stefan} and {Paeschke Katrin}},
title = {Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres},
publisher = {Bentham Science Publ.},
year = 2012,
month = may,
journal = {Current pharmaceutical design},
volume = 2012, vol. 18,
number = iss. 14,
pages = 1867--1872,
note = {DNA and RNA regions containing tracts of guanines can form very stable secondary structures called G-quadruplex (G4). Genomic sequences with the potential to form G4 (G4-motifs) are abundant across species. In all analyzed genomes G4 motifs are found near promoter regions and double strand break sites and at telomeres. Telomeres are very G-rich and prone for G4 formation. Therefore they are routinely used in in vitro and in vivo experiments to elucidate the function of G4 structures in telomere metabolism. Recently various labs demonstrated that telomere length maintenance is mediated via G4 structures. Telomere-binding proteins specifically bind to G4 structure and regulate this structure throughout the cell cycle.},
url = {https://hdl.handle.net/20.500.11811/11478}
}
author = {{A. Juranek Stefan} and {Paeschke Katrin}},
title = {Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres},
publisher = {Bentham Science Publ.},
year = 2012,
month = may,
journal = {Current pharmaceutical design},
volume = 2012, vol. 18,
number = iss. 14,
pages = 1867--1872,
note = {DNA and RNA regions containing tracts of guanines can form very stable secondary structures called G-quadruplex (G4). Genomic sequences with the potential to form G4 (G4-motifs) are abundant across species. In all analyzed genomes G4 motifs are found near promoter regions and double strand break sites and at telomeres. Telomeres are very G-rich and prone for G4 formation. Therefore they are routinely used in in vitro and in vivo experiments to elucidate the function of G4 structures in telomere metabolism. Recently various labs demonstrated that telomere length maintenance is mediated via G4 structures. Telomere-binding proteins specifically bind to G4 structure and regulate this structure throughout the cell cycle.},
url = {https://hdl.handle.net/20.500.11811/11478}
}
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