E-Dissertationen: Auflistung E-Dissertationen nach Autor "Pankratz, Michael"
Anzeige der Dokumente 1-20 von 29
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Analysis of the regulatory function of amino acids on metabolic targets and serotonin production in Drosophila melanogaster
Hübner, Tatjana (2016-08-09)Amino acid sensing mediates metabolic and behavioural adjustments in response to organismal needs. Several pathways are believed to be involved in amino acid sensing, including the TOR (Target of Rapamycin) pathway. However, ... -
Aptamer-mediated transactivation of transcription utilizing CRISPR/Cas9 and a photoreceptor
Renzl, Christian (2021-12-16)In synthetic biology, spatio-temporal control of molecular functions is an essential tool for the investigation and manipulation of cellular processes. The usage of light enables a reversible non-invasive trigger, that ... -
Cellular and synaptic correlates of learning and memory and their impairment in a mouse model of Alzheimer's disease
Poll, Stefanie (2017-11-28)Alzheimer's disease (AD) is characterized by synaptic dysfunction and progressive memory loss. The hippocampus is indispensable for memory processes and early affected by disease-associated pathology. It is still debated ... -
Characterization of small molecule inhibitors of the NLRP3 inflammasome
Monks, Brian (2021-08-04)To respond quickly to infection, the innate immune system contains many germline encoded pattern recognition receptors (PRRs) that recognize a myriad of danger signals released by pathogens and damaged tissues. NLRP3 ... -
Characterization of the hyperpolarization-activated, highly-selective proton channel HCNL1 found in the sperm of the zebrafish Danio rerio
Wobig, Lea (2021-04-29)Zebrafish are external fertilizers and release their gametes into the surrounding water. Yet, the freshwater environment with its low osmolarity poses a challenge for the gametes. Given these unique ion conditions, it seems ... -
The Control of Food Intake and Bitter Taste Information Processing in the Drosophila Larval Brain
Hückesfeld, Sebastian (2016-12-22)The regulation of feeding behavior by central neural circuits is crucial for every organism to survive. Hierarchical organized motor systems are responsible for the execution of appropriate feeding movements and can be ... -
Deciphering the functional role of the LIS1/NDEL1/14.3.3ε protein complex in the expansion of human cortical progenitors in an iPSC-derived organoid model
Iefremova, Vira (2021-07-19)The human brain is an exceptionally complex organ, both structurally and functionally, and represents the most remarkable progress in evolution. The human cortex is a highly organised and extensively folded structure ... -
Enoki mushroom (enok) – ein neuer epigenetischer Regulator von Lipidmetabolismus, Wachstum und Nahrungsaufnahme in Drosophila melanogaster
Moderau, Nina (2016-12-09)Um das Überleben eines Organismus zu gewährleisten, bedarf es eines exakten Zusammenspiels von verschiedenen Genen, die zeit- und gewebespezifisch reguliert werden müssen, um das externe Nahrungsangebot zu detektieren, die ... -
Plexin-A2 and neuropilin-2 in the axonal guidance of cranial nerves in avian embryos
Haque, Ziaul (2014-03-17)Secreted class-III semaphorins exert their effects in axon guidance and neuronal migration by binding with receptors, such as plexins and neuropilins. Neuropilins are insufficient to convey signals of their own; rather, ... -
Expression and Function of ErbB4 Splice Variants in the Central Nervous System
Erben, Larissa (2019-07-18)Neuregulins and their cognate neuronal receptor tyrosine kinase ErbB4 (<em>avian erythroblastosis virus oncogene B4</em>) are genetically linked with an increased risk for schizophrenia. NRG/ErbB4 signaling regulates ... -
Funktionelle neuroanatomische Analyse eines nahrungsabhängigen Schaltkreises in Drosophila melanogaster
Peters, Marc (2014-03-13)Eine weltweit zunehmende Fehlernährung und die damit verbundenen Stoffwechselerkrankungen wie Diabetes haben die Aufklärung neuropeptiderger Systeme vorangetrieben, die an einer Regulation der Nahrungsaufnahme beteiligt ... -
The importance of endogenous opioids in feeding behavior
Ghule, Aishwarya (2018-03-14)Endogenous opioids are involved in a broadly distributed neural network regulating eating behavior. Opioid transmission has long been implicated in controlling hedonic and homeostatic feeding as well as regulating body ... -
Inhibitory Circuits of the CA3-Dentate Gyrus System
Müller-Komorowska, Daniel (2021-11-04)Neuronal inhibition is an essential feature of all brain areas. Besides controlling the average rate of neuronal firing, it also controls the precise timing of action potentials and mediates several types of network ... -
Investigating pathomechanisms underlying malformations of human cortical development
Jabali, Ammar Alexander (2023-06-15)During human development the brain has to form a complex neuronal network requiring a well-orchestrated sequence of neurogenesis, neuronal migration and correct positioning within cortical layers followed by synaptogenesis. ... -
Investigating the neural circuitry of the Mushroom body calyx in Drosophila melanogaster
Ranft, Philipp (2020-07-15)In Drosophila melanogaster, the mushroom body (MB) is essential for the formation and retrieval of olfactory associative memories. Within its input region, the MB calyx, olfactory information is delivered from second order ... -
Large scale in vivo recordings of dentate gyrus granule cells during trace eyeblink conditioning
Distler, Fabian (2024-02-29)(noch nicht zugänglich / not yet accessible) -
Neuronal and Circuit Architecture Underlying Feeding Behavior in Drosophila
Miroschnikow, Anton (2021-06-28)Feeding is elemental for survival and one of the most common activities of animals. Little is known about the organization of neuronal circuits controlling feeding behavior in the cen-tral nervous system. This study maps, ... -
Physiological role of cation channels of P. irradians ciliary photoreceptors and human sperm
Echeverry, Fabio Andrés (2017-04-07)Eukaryotic flagella and cilia are antenna-like cellular extrusions, shaped by microtubules and covered by a specialized extension of the plasma membrane. They serve several tasks, like light and olfactory sensation or cell ... -
The role of glial calcium changes in animal models of stroke
Rakers, Cordula Marijke (2015-12-04)Ischemic stroke represents one of the leading causes of death and disability. A main characteristic of the early phase of stroke is the spontaneous appearance of peri-infarct depolarizations (PIDs), which are known to ... -
Role of the cannabinoid receptor 2 in the development of surgical neuropathic pain
Nent, Elisa (2018-12-12)When normal nociceptive pain becomes chronic, it loses its protective function and causes a general pain hypersensitivity. Neuropathic pain is one type of chronic pain, which is caused by various diseases or physical injury ...