Mathematisch-Naturwissenschaftliche Fakultät: E-Dissertationen
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Enhancing Data Interoperability in Alzheimer's Disease Cohort Studies via Comprehensive Semantic and Statistical Analyses
(2025-04-16)As a prominent neurodegenerative disorder, Alzheimer's disease causes extensive cognitive decline and remains a substantial public health concern. Despite extensive research to understand the pathology of the disease, no ... -
Studies of a Digital SiPM and MAPS Prototypes as Key Technologies for Future High-Energy Physics Experiments
(2025-04-14)Digital Silicon Photomultipliers (dSiPMs) and Monolithic Active Pixel Sensors (MAPS) are emerging technologies, fabricated using commercial Complementary Metal-Oxide-Semiconductor (CMOS) processes. These detectors have the ... -
Maternal Nutritional Influence on Progeny Physiology, Longevity, and Immune System in Drosophila melanogaster
(2025-04-10)Maternal obesity can influence the health of offspring through immunity, epigenetic regulations, telomeres length and development of gut dysbiosis, cancer, diabetes and brain disorders, which may also affect the long term ... -
Pharmacometrics as a tool to individualize treatment with anti-infective drugs
(2025-04-09)The pharmacometrics models, such as population (Pop) pharmacokinetic (PK) models, were developed to explain the variability in PK parameters of anti-infective drugs including cefiderocol cefepime, rifampicin, and remdesivir, ... -
Synthese Funktionalisierter Phenylen-Ethinylen-Stäbchen zur Parkettierung von HOPG-Oberflächen
(2025-04-08)Im Rahmen der vorliegenden Arbeit wurden monodisperse funktionalisierte Phenylen–Ethinylen-Stäbchen synthetisiert, welche auf hochorientiertem pyrolytischem Graphit (HOPG) selbstassemblierten Monolagen (SAM) bilden. Die ... -
Navigating Urban Riskscapes: Everyday Risks, Infrastructure Challenges, and Governance in Monrovia, Liberia
(2025-04-07)As cities in the Global South encounter increasingly complex urban landscapes shaped by environmental, socio-political, infrastructural, and health-related risks, governance challenges intensify. This thesis critically ... -
3D culture conditions instruct an in vivo-like phenotype in primary microglia
(2025-04-01)(noch nicht zugänglich / not yet accessible) -
Dynamical Effects in Heavy-Fermion Systems
(2025-03-27)When atoms in solids have unfilled <em>d</em>- or <em>f</em>-orbitals, local Coulomb interaction often becomes non-negligible due to the strongly localized nature of those orbitals. A hallmark effect of such systems is the ... -
Revisiting the innate immune response using systems immunology
(2025-03-26)(noch nicht zugänglich / not yet accessible) -
Spectroscopy and the Path to Laser Cooling of Zinc
(2025-03-26)To enable laser cooling of zinc, a deep UV laser system for the main cooling transition at 214 nm has been developed. The system relies on frequency-quadrupling a titanium-sapphire laser in two consecutive frequency-doubling ... -
Population structure, reproductive behaviour and population density of the European wild boar, Sus scrofa, based on STR marker studies of hunting bags in Lower Saxony, Germany
(2025-03-25)Population densities and relative abundance of the European wild boar, Sus scrofa, has been steadily increasing throughout Europe for decades. Due to climate changes, wild boar is able to expand into climatic regions that ... -
Design and Multistep Synthesis of Ligands for the GPR18 and GPR183: Related Orphan G Protein-Coupled Receptors with Immunoregulatory Functions
(2025-03-24)(noch nicht zugänglich / not yet accessible) -
Exploring and Addressing General Limitations of Compound Potency Predictions using Machine Learning
(2025-03-24)Compound potency prediction is a major task in computational drug discovery. Regression models based on machine learning (ML) approaches have become popular for small molecule potency predictions. Recently, deep learning ... -
Synthesis of Chromophore Decorated Ligands and their Self-Assembly into Supramolecular Coordination Complexes
(2025-03-20)This thesis is concerned with the synthesis and characterization of chromophore decorated self-assembled coordination complexes (SCC’s). The SCC’s were constructed from ditopic bispyridine ligands as organic donor building ... -
Establishment of bioanalytical workflows for the quality assessment of formulated proteins
(2025-03-17)Proteins and peptides contribute to a significant class of therapeutic agents in the pharmaceutical market. Over the last decades, they gained growing interest due to their safety and specificity compared to small molecule ... -
Rab requirements in HOPS-mediated late endosome-lysosome tethering and dissection of fusion factor requirements in Ca2+-dependent phagosome-lysosome fusion
(2025-03-17)Through sequential fusion with early- and late endosomes (EEs and LEs) and ultimately lysosomes (LYS), a degradative (endo-)lysosome ((E)LYS is formed. Directionality of fusion is ensured by the action of Ras-like GTPases ... -
Transcriptomic heterogeneity of microglia in relation to Alzheimer's disease-associated pathology and post-mortem delay
(2025-03-17)(noch nicht zugänglich / not yet accessible) -
Advanced deep learning methods for quantifying imaging biomarkers in large cohort studies
(2025-03-14)Understanding the anatomical structures of the body and brain, and their influence on human health throughout the lifespan is of significant research and clinical interest. Tracking of structural changes can provide insights ... -
Multi-Person Pose Tracking in Videos
(2025-03-14)This thesis addresses the complex challenges of multi-person pose estimation and tracking in dynamic, real-world environments. Motivated by advancements in artificial intelligence and the growing need for natural human-machine ... -
Investigating the molecular mechanisms involved in the developmental assembly of the mushroom body calyx in Drosophila melanogaster
(2025-03-11)How a circuit functions can be investigated by examining the organisation of the circuit to be able to decipher the connectivity logic and the logic of information flow within that circuit. Hence, to understand how the ...
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