E-Dissertationen: Browsing E-Dissertationen by Author "Geyer, Matthias"
Now showing items 1-9 of 9
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Die Aktivierung des NLRP3 Inflammasoms durch RAN Peptide beim Morbus Huntington
Jamin, Raúl Nicolas (2023-08-29)Neuroinflammation als ein treibender Faktor der Pathologie verschiedener neurodegenerativer Erkrankungen spielt auch in der Pathologie von HD eine relevante Rolle. Durch die Entdeckung von RAN Translation, einem Mechanismus ... -
Characterization of a novel multiprotein complex downstream of the cytosolic nucleic acid sensors cGAS and RIG-I
Kirchhoff, Alexander (2021-08-30)Detection of viral nucleic acids by specialized PRRs of the innate immune system triggers the expression of type I IFNs, a hallmark of antiviral defense. In vertebrates, the cGAS-STING pathway and the RLR-MAVS pathway have ... -
From pattern recognition to pro-inflammatory cell death - Functional characterization of the proteins NLRP7 and GSDMD
Kopp, Anja (2023-12-07)Inflammasomes are cytosolic multi-protein complexes that form in response to infection or other harmful stimuli to induce innate immune responses. The core components of inflammasomes are pattern recognition ... -
Die immunsuppressive Rolle von N-Myc im Neuroblastom
Layer, Julian Philipp (2018-12-18)Das Neuroblastom ist ein embryonaler Tumor der Neuralleiste mit sehr variablem klinischen Verlauf. Aufgrund der großen Heterogenität der Erkrankung besteht ein enormer Bedarf an spezifischeren Methoden zur Risikostratifizierung ... -
Interplay of IKKs and IKK-related kinases in antiviral nucleic acid receptor signaling in human monocytes
Wegner, Julia (2022-06-21)Monocytes and monocyte-derived cells are among the first line of host defense against invading pathogens. They are equipped with pattern recognition receptors (PRRs) that detect conserved components of microbes and in ... -
Investigating the molecular basis of human NLRP1 inflammasome activation
Möcking, Jonas (2020-03-10)Cytosolic sensor proteins like NLRP1 (NOD-like receptor containing a pyrin domain 1) play a fundamental role in mediating innate immunity. Upon activation they form signalling hubs that recruit the adaptor protein ASC ... -
Investigation of novel pathways causing autoinflammatory disease
Steiner, Annemarie (2022-05-17)Autoinflammatory diseases (AIDs) are rare pathologies caused by mutations in genes associated with innate immune pathways. Investigating the underlying molecular defects contributes to identification of targeted treatment ... -
Sphingomyelin d18:1/14:0 and TLR4: Fueling the Fire in Metaflammation
Gorki, Friederike Sophie (2024-02-29)Metaflammation, the chronic low-grade inflammation originating from metabolic organs such as adipose tissue and liver, is associated with many prevalent non-communicable diseases such as obesity, type 2 diabetes and ... -
TAR DNA-binding Protein 43 as a Damage-associated Molecular Pattern in Amyotrophic Lateral Sclerosis-related Neuroinflammation
Meyer, Tizian Keno (2024-01-10)ALS as one of the most common and aggressive neuromuscular diseases is characterized by rapidly progressing and, in later stages, generalized muscular decline. As of today, limited therapeutic options exist and there is ...