Faculties of University Bonn: Search
Now showing items 21-29 of 29
Generation and Applications of Knowledge Graphs in Systems and Networks Biology
(2019-12-16)
The acceleration in the generation of data in the biomedical domain has necessitated the use of computational approaches to assist in its interpretation. However, these approaches rely on the availability of high quality, ...
Computational Analysis of Pathophysiological Mechanisms Based on Pathway Modeling
(2019-12-18)
The advent of the big data era poses major challenges to the biomedical domain. First, it is necessary to adopt strategies that integrate and link the heterogeneous resources that contain multiscale and multimodal data in ...
Scalable Algorithms for Parallel Tree-based Adaptive Mesh Refinement with General Element Types
(2018-12-12)
In this thesis, we develop, discuss and implement algorithms for scalable parallel tree-based adaptive mesh refinement (AMR) using space-filling curves (SFCs). We create an AMR software that works independently of the used ...
Knowledge Management approaches to model pathophysiological mechanisms and discover drug targets in Multiple Sclerosis
(2019-04-30)
Multiple Sclerosis (MS) is one of the most prevalent neurodegenerative diseases for which a cure is not yet available. MS is a complex disease for numerous reasons; its etiology is unknown, the diagnosis is not exclusive, ...
A water storage reanalysis over the European continent: assimilation of GRACE data into a high-resolution hydrological model and validation
(2019-04-18)
Continental water storage and redistribution within the Earth’s system are key variables of the terrestrial water cycle. Changes in water storage and fluxes may affect resources for drinking water and irrigation, lead ...
On some Geometric Search Problems: Algorithms, Complexity, Computability
(2020-11-25)
This thesis considers four search problems which are related to or emerge from a geometric context. Each search problem is examined in a separate chapter; these four chapters are framed by an introduction and a conclusion ...
Contextualizing and interpreting biological data with pathway knowledge and network algorithms
(2023-02-07)
Elucidating the mechanisms which give rise to unique biological functions is a major goal of human biology. Vast quantities of biological data that have been amassed can aid us in understanding these mechanisms, such as ...
Time Filter Assisted Deep Learning to Predict Air Pollution
(2023-07-13)
Exposure to ground-level ozone harms human health as well as the entire ecosystem, so accurate prediction of ozone exposure is of particular importance. Machine learning (ML), and deep learning (DL) in particular, has ...
Deep Generative Modelling in Systems Medicine: From Transcriptomics Data to Drug Development
(2024-02-02)
(noch nicht zugänglich / not yet accessible)