Fachgruppe Pharmazie: Auflistung Fachgruppe Pharmazie nach Erscheinungsdatum
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Irreversible Antagonists for the Adenosine A2B Receptor
(2022-06-13)Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based ... -
Photocaged Histone Deacetylase Inhibitors as Prodrugs in Targeted Cancer Therapy
(2023-02-25)Histone deacetylases (HDACs) play a key role in the control of transcription, cell prolifer- ation, and migration. FDA-approved histone deacetylase inhibitors (HDACi) demonstrate clinical efficacy in the treatment of ... -
A Systematic Database Approach to Identify Companion Diagnostic Testing in Clinical Trials under the New In Vitro Diagnostic Medical Devices Regulation
(2023-06-12)The European Union In Vitro Diagnostic Medical Devices Regulation (EU) 2017/746 (IVDR) introduces companion diagnostics (CDx) as a new legal term. CDx are applied in combination with a medicinal product to identify patient ... -
Development of the first geldanamycin-based HSP90 degraders
(2023-06-28)Despite the early clinical promise, adverse events such as acquired resistance and dose-limiting toxicities have barred the widespread use of HSP90 inhibitors as anticancer drugs. A new approach involving proteolysis-targeting ...
