Medizinische Fakultät: Suche
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The cell biology of the FcRn-albumin recycling system
(2022-08-10)
Human serum albumin (HSA) is the most abundant protein in plasma and has an exceptionally long circulatory half-life of around three weeks in humans. The enhanced half-life properties of HSA result from the selective ...
The mind's ratio: How the balance between ω-6 and ω-3 fatty acids affects the risk of late-life dementia
(2022-02-03)
Dementia health care costs are rapidly rising due to the increasing number of people with dementia worldwide that is expected to increase to 66 million by 2030 and 115 million by 2050 (Prince et al., 2013). Intensive ......
Unravelling the role of RIM proteins in synaptic transmission: RIM1α tunes Ca2+ channel subtype contribution to neurotransmitter release
(2019-04-12)
Synaptic transmission is extremely fast and tightly regulated due to the rapid and spatially restricted Ca2+ signal at the presynaptic active zone (AZ). At the AZ, voltage-gated Ca2+ channels (VGCC) ...
Shedding light on the role of cAMP in mammalian sperm physiology
(2018-06-15)
Mammalian fertilization relies on sperm finding the egg and penetrating the egg vestments. All steps in a sperm's lifetime crucially rely on changes in the second messenger cAMP (cyclic adenosine monophosphate). In recent ...
Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors
(2019-11-14)
The second messenger 3´, 5´-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil ...
How to control cyclic nucleotide signaling by light
(2017-03-10)
Optogenetics allows to non-invasively manipulate cellular functions with spatio-temporal precision by combining genetic engineering with the control of protein function by light. Since the discovery of channelrhodopsin has ......
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Targeting the Microbiome by NLRP6 Deletion and the Development of Murine Alzheimer’s Disease
(2022-07-11)
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain
disorder. The progression of AD is characterized by the deposition of amyloid-β
peptides and hyperphosphorylated Tau proteins, causing loss ...
Investigation of Heat Shock Protein 70 and Toll-like Receptor 4 functions during inflammation reaction by mechanical compression in human periodontal ligament cells
(2021-06-24)
Biomechanical forces exerted during treatment with orthodontic appliances cause tensile and compressive strain within the periodontal ligament (PDL) of affected teeth followed by ischemia on the compression side. Further, ...
Somatic cell-derived extracellular vesicles and phenotypic outcomes in the next generation
(2023-05-31)
Evidence from both human and animal studies demonstrate that paternal experiences and exposures can cause phenotypic changes in the next generation. Extracellular vesicles (EVs) released by somatic cells are hypothesised ...