The Faculty of Medicine: Search
Now showing items 61-70 of 95
Development of a CRISPR/Cas9 based RiboTag strategy to identify regulators of melanoma immune interaction
(2023-11-09)
The development of immunotherapy approaches has revolutionised the field of melanoma treatment by prolonging the survival of patients. Nevertheless, a significant proportion of patients either do not respond to immunotherapy ...
Role of the chemokines CCL17 and CCL22 in bacterial infection and IL-33-induced immune responses
(2023-11-24)
The chemokines CCL17 and CCL22 are primarily expressed by dendritic cells (DC) and macrophages. Both chemokines share the receptor CCR4, which is expressed on DC and macrophages as well as on a variety of different T cell ......
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)
Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ......
Characterization of the pro-inflammatory activity of short-chain fatty acids (SCFAs)
(2021-10-13)
Short-chain fatty acids (SCFAs), which are mainly derived from microbial fermentation of dietary fibres, have been considered to be beneficial to gut health for decades. Recently, a few of studies reported that some patients ...
Functional and cellular heterogeneity of the myeloid cell system
(2020-11-09)
Cells of the myeloid lineage form the innate part of the immune system and are characterized by a high level of functional plasticity, which is required to address the diverse set of functions of these mononuclear cells. ...
RIM4 deficiency leads to reduced somato-dendritic excitability of cerebellar Purkinje cells
(2023-12-14)
Synaptic function is determined by the release machinery at the active zone which is composed of a large number of synaptic proteins including RIMs. The large RIMs are key components of the presynaptic active zone that ...
Contribution of SIGLEC-11 and SIGLEC-16 receptors to neuro-inflammation and neurodegeneration
(2023-02-14)
Brain aging is a multifactorial process including accumulation of aged lipids and proteins,
neuroinflammation and loss of neurons. SIGLEC-11 and SIGLEC-16 are paired opposite inhibitory- versus activatory-signaling ...
The interplay of fatty acid synthesis, metabolism, and immune function during Flavivirus infection
(2023-10-04)
Macrophage activation and Flavivirus infection can both fundamentally alter cellular metabolism and change the lipid landscape of cells. Flaviviruses upregulate fatty acid synthesis to build membranous replication complexes, ...
From pattern recognition to pro-inflammatory cell death - Functional characterization of the proteins NLRP7 and GSDMD
(2023-12-07)
Inflammasomes are cytosolic multi-protein complexes that form in response to infection or other harmful stimuli to induce innate immune responses. The core components of inflammasomes are pattern recognition ...
Deciphering the role of human-specific genes in the development of the human neocortex
(2024-01-04)
The human brain is remarkably complex and has been subject to noteworthy changes throughout evolution. An expansion of progenitor cells is thought to contribute to the complexity and increase in cortical size that is ......