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  • 33/m: Komplettierung des Impfstatus vor Praktikum in Kindertagesstätte: Vorbereitung auf die Facharztprüfung: Fall 52 

    Dehnen, Dorothea; Reinsdorff, Melanie; Weltermann, Birgitta (2024-07-11)
    <strong>Prüfungssimulation</strong><br /> <strong><em>Fallschilderung</strong></em><br /> Ein 33-jähriger Student des Fachs Kindheitspädagogik möchte in 6 Wochen sein erstes Praktikum in einer Kindertagesstätte ...

  • Mouse models of type I interferonopathies 

    Luca, Domnica; Kato, Hiroki (2024-12-16)
    Type I interferonopathies are severe monogenic diseases caused by mutations that result in chronically upregulated production of type I interferon. They present with a broad variety of symptoms, the mechanisms of which are ...

  • Epidemiology and outcomes of vancomycin-resistant enterococcus infections: A systematic review and meta-analysis 

    Eichel, Vanessa M.; Last, Katharina; Brühwasser, Christina; Baum, Heike von; Dettenkofer, Markus; Götting, Tim; Grundmann, Hajo; Güldenhöven, Hanna; Liese, Jan; Martin, Maria; Papan, Cihan; Sadaghiani, Catharina; Wendt, Constanze; Werner, Guido; Mutters, Nico (2023-09-19)
    Vancomycin-resistant enterococci (VRE) cause many infections in the healthcare context. Knowledge regarding the epidemiology and burden of VRE infections, however, remains fragmented. We aimed to summarize recent studies ...

  • Evaluating AI Courses: A Valid and Reliable Instrument for Assessing Artificial-Intelligence Learning through Comparative Self-Assessment 

    Laupichler, Matthias Carl; Aster, Alexandra; Perschewski, Jan-Ole; Schleiss, Johannes (2023-09-26)
    A growing number of courses seek to increase the basic artificial-intelligence skills ("AI literacy") of their participants. At this time, there is no valid and reliable measurement tool that can be used to assess AI-learning ...

  • Key factors for sustainable working conditions in emergency departments: An EUSEM-initiated, Europe-wide consensus survey 

    Weigl, Matthias; Lifschitz, Michael; Dodt, Christoph (2025-02)
    <em>Background and importance</em> Modern emergency medicine (EM) is a complex, demanding, and occasionally stressful field of work. Working conditions, provider well-being, and associated health and performance outcomes ...

  • Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function 

    Khani, Sajjad; Topel, Hande; Kardinal, Ronja; Tavanez, Ana Rita; Josephrajan, Ajeetha; Larsen, Bjørk Ditlev Marcher; Gaudry, Michael James; Leyendecker, Philipp; Meincke Egedal, Nadia; Güller, Aylin Seren; Stanic, Natasa; Ruppert, Phillip M. M.; Gaziano, Isabella; Hansmeier, Nils Rouven; Schmidt, Elena; Klemm, Paul; Vagliano, Lara-Marie; Stahl, Rainer; Duthie, Fraser; Krause, Jens-Henning; Bici, Ana; Engelhard, Christoph Andreas; Gohlke, Sabrina; Frommolt, Peter; Gnad, Thorsten; Rada-Iglesias, Alvaro; Pradas-Juni, Marta; Schulz, Tim Julius; Wunderlich, Frank Thomas; Pfeifer, Alexander; Bartelt, Alexander; Jastroch, Martin; Wachten, Dagmar; Kornfeld, Jan-Wilhelm (2024-04-29)
    Promoting brown adipose tissue (BAT) activity innovatively targetsobesity and metabolic disease. While thermogenic activation of BAT is wellunderstood, the rheostatic regulation of BAT to avoid excessive energy dissipation ...

  • TFAP2E is implicated in central nervous system, orofacial and maxillofacial anomalies 

    Kalanithy, Jeshurun C.; Mingardo, Enrico; Stegmann, Jil D.; Dhakar, Ramgopal; Dakal, Tikam Chand; Rosenfeld, Jill A.; Tan, Wen-Hann; Coury, Stephanie A.; Woerner, Audrey C.; Sebastian, Jessica; Levy, Paul A.; Fleming, Leah R.; Waffenschmidt, Lea; Lindenberg, Tobias T.; Yilmaz, Öznur; Channab, Khadija; Babra, Bimaljeet K.; Christ, Andrea; Eiberger, Britta; Hölzel, Selina; Vidic, Clara; Häberlein, Felix; Ishorst, Nina; Rodriguez-Gatica, Juan E.; Pezeshkpoor, Behnaz; Kupczyk, Patrick A.; Vanakker, Olivier M.; Loddo, Sara; Novelli, Antonio; Dentici, Maria L.; Becker, Albert; Thiele, Holger; Posey, Jennifer E.; Lupski, James R.; Hilger, Alina C.; Reutter, Heiko M.; Merz, Waltraut M.; Dworschak, Gabriel C.; Odermatt, Benjamin (2024-12-23)
    <strong>Background</strong> Previous studies in mouse, <em>Xenopus</em> and zebrafish embryos show strong <em>tfap2e</em> expression in progenitor cells of neuronal and neural crest tissues suggesting its involvement in ...

  • NIS-Seq enables cell-type-agnostic optical perturbation screening 

    Fandrey, Caroline I.; Jentzsch, Marius; Konopka, Peter; Hoch, Alexander; Blumenstock, Katja; Zackria, Afraa; Maasewerd, Salie; Lovotti, Marta; Lapp, Dorothee J.; Gohr, Florian N.; Suwara, Piotr; Świeżewski, Jędrzej; Rossnagel, Lukas; Gobs, Fabienne; Cristodaro, Maia; Muhandes, Lina; Behrendt, Rayk; Lam, Martin C.; Walgenbach, Klaus J.; Bald, Tobias; Schmidt, Florian I.; Latz, Eicke; Schmid-Burg, Jonathan L. (2024-12-19)
    Optical pooled screening offers a broader-scale alternative to enrichment-based perturbation screening, using fluorescence microscopy to correlate phenotypes and perturbations across single cells. Previous methods work ...

  • Large-scale production of Mansonella perstans infective larvae from engorged Culicoides milnei 

    Kien, Chi Anizette; Ebai, Rene; Fombad, Fanny Fri; Esofi, Frederick; Ntuh, Anna Ning; Ouam, Emmanuel; Gandjui, Narcisse Victor Tchamatchoua; Chunda, Valerine Chawa; Ekanya, Relindis; Nietcho, Franck Noel; Foyet, Juluis Visnel; Nchang, Lucy Cho; Magha, Chefor; Njouendou, Abdel Jelil; Enyong, Peter; Hoerauf, Achim; Ritter, Manuel; Wanji, Samuel (2024-12-10)
    <strong>Background:</strong> <em>Mansonella perstans</em> is transmitted by <em>Culicoides</em> species and affects hundred millions of inhabitants in about 33 countries in sub-Saharan Africa. It is known that Mansonellosis ...

  • Schistosomiasis–Microbiota Interactions: A Systematic Review and Meta-Analysis 

    Afful, Philip; Abotsi, Godwin Kwami; Adu-Gyamfi, Czarina Owusua; Benyem, George; Katawa, Gnatoulma; Kyei, Samuel; Arndts, Kathrin; Ritter, Manuel; Asare, Kwame Kumi (2024-10-16)
    Introduction: Schistosomiasis, a tropical disease affecting humans and animals, affected 251.4 million people in 2021. <em>Schistosoma mansoni, S. haematobium, S. intercalatum</em>, and <em>S. japonicum</em> are primary ...

  • Barriers and Facilitators of Patient Engagement Activities to Improve Patient Safety in Healthcare Organizations: A Delphi-Based Expert Survey 

    Koch, Amelie; Brust, Larissa; Weigl, Matthias (2024-12-19)
    <strong>Purpose:</strong> In order to obtain sustainable healthcare, engagement of patients in patient safety improvement is vital. Drawing upon a multi-perspective approach, this study aimed to investigate perspectives ...

  • Comorbidity profiles among sputum-positive tuberculosis patients in Cameroon 

    Magha, Chefor; Nchang, Lucy Cho; Weldeslassie, Michael; Nkimbeng, Desmond Akumtoh; Tchatat, Nancielle Mbiatong; Meriki, Henry Dilonga; Deribe, Kebede; Nietcho, Frank Noel; Foyet, Juluis Visnel; Fombad, Fanny Fri; Katcho, Tatiana Djikeussi; Fru Cho, Jerome; Gebremeskel, Eyoab Iyasu; Waddell, Simon J.; Bobosha, Kidist; Newport, Melanie J.; Hoerauf, Achim; Ritter, Manuel; Wanji, Samuel (2024-10-02)
    <strong>Introduction:</strong> Comorbid non-communicable diseases (NCDs) like diabetes, cardiovascular diseases (CVD), kidney diseases, and hypertension, could have implications for tuberculosis (TB) treatment management ...

  • Innovative Regional Services and Heterogeneous Communication Channels: Results from the Nationwide German egePan Project for Pandemic Management 

    Kugai, Simon; Aretz, Benjamin; Krumpholtz, Yelda; Schmidt, Manuela; Süssle, Daniela; Steyer, Linda; Henkel, Adrienne; Bender, Katrin; Girrbach, Felix; Stehr, Sebastian; Balzer, Katrin; Weltermann, Birgitta (2024-11-04)
    <strong>Background:</strong> In the COVID-19 pandemic, novel regional services and communication channels emerged across all sectors of the German healthcare system. To contribute to pandemic preparedness, this study aims ...

  • Schistosomiasis endemicity and its role in sexually transmitted infections: A systematic review and meta-analysis 

    Asare, Kwame Kumi; Afful, Philip; Abotsi, Godwin Kwami; Adu-Gyamfi, Czarina Owusua; Benyem, George; Katawa, Gnatoulma; Arndts, Kathrin; Ritter, Manuel (2024-09-02)
    <strong>Introduction:</strong> Schistosomiasis, a tropical parasitic disease, affects 779 million people globally, with 85% of cases in Africa. The interplay between schistosomiasis and other sexually transmitted infections ...

  • In vitro extracellular replication of Wolbachia endobacteria 

    Behrmann, Lara Vanessa; Meier, Kirstin; Vollmer, Jennifer; Chiedu, Chukwuebuka Chibuzo; Schiefer, Andrea; Hoerauf, Achim; Pfarr, Kenneth (2024-07-18)
    Obligate intracellular endobacteria of the genus <em>Wolbachia</em> are widespread in arthropods and several filarial nematodes. Control programs for vector-borne diseases (dengue, Zika, malaria) and anti-filarial therapy ...

  • Bidirectional Effect of Long-Term Δ9‑Tetrahydrocannabinol Treatment on mTOR Activity and Metabolome 

    Bilkei-Gorzo, Andras; Schurmann, Britta; Schneider, Marion; Kraemer, Michael; Nidadavolu, Prakash; Beins, Eva C.; Müller, Christa E.; Dvir-Ginzberg, Mona; Zimmer, Andreas (2024-08-14)
    Brain aging is associated with cognitive decline, reduced synaptic plasticity, and altered metabolism. The activity of mechanistic target of rapamycin (mTOR) has a major impact on aging by regulating cellular metabolism. ...

  • The impact of the mesoprefrontal dopaminergic system on the maturation of interneurons in the murine prefrontal cortex 

    Islam, K. Ushna S.; Blaess, Sandra (2024-07-05)
    The prefrontal cortex (PFC) undergoes a protracted maturation process. This is true both for local interneurons and for innervation from midbrain dopaminergic (mDA) neurons. In the striatum, dopaminergic (DA) neurotransmission ...

  • Comparative development of human filariae Loa loa, Onchocerca volvulus and Mansonella perstans in immunocompromised mouse strains 

    Chunda, Valerine C.; Fombad, Fanny Fri; Kien, Chi Anizette; Ebai, Rene; Esofi, Frederick; Ntuh, Anna Ning; Ouam, Emmanuel; Gandjui, Narcisse Victor Tchamatchoua; Ekanya, Relindis; Nietcho, Franck; Nchang, Lucy Cho; Magha, Chefor; Njouendou, Abdel Jelil; Enyong, Peter; Hoerauf, Achim; Wanji, Samuel; Ritter, Manuel (2024-04-15)
    <strong>Introduction:</strong> Mouse models of human filarial infections are not only urgently needed to investigate the biology of the nematodes and their modulation of the host's immunity, but will also provide a platform ...

  • The unusual mode of action of the polyketide glycoside antibiotic cervimycin C 

    Hoffmann, Alina; Steffens, Ursula; Maček, Boris; Franz-Wachtel, Mirita; Nieselt, Kay; Harbig, Theresa Anisja; Scherlach, Kirstin; Hertweck, Christian; Sahl, Hans-Georg; Bierbaum, Gabriele (2024-05-09)
    Cervimycins A–D are bis-glycosylated polyketide antibiotics produced by <em>Streptomyces tendae</em> HKI 0179 with bactericidal activity against Gram-positive bacteria. In this study, cervimycin C (CmC) treatment caused a ...

  • The role of dendritic cells in MASH: friends or foes? 

    Pinto, Antonio T.; Lukacs-Kornek, Veronika (2024-04-08)
    Dendritic cells (DCs) are major antigen-presenting cells that connect innate and adaptive immunity. Hepatic DCs are less activated and contribute to maintain the tolerogenic environment of the liver under steady state. ...

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