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Identification of cisplatin resistance mechanisms and alternative treatment options for testicular germ cell tumors
Funke, Kai (2023-06-21)Type II testicular germ cell tumors (TGCTs) are the most prevalent tumors in young men aged 18 to 35 years. TGCTs are classified as seminomas and non-seminomas. Embryonal carcinomas (EC), representing the cancer stem cell ... -
Identification of components and substrates of Snf1-related kinase 1 (SnRK1) complexes in Arabidopsis thaliana
Bai, Bing (2019-04-04)Similarly to yeast Sucrose nonfermenting 1 (Snf1) and animal AMP-activated protein kinases (AMPKs), plant Snf1-related (SnRK1) kinases play a central role in the regulation of cellular energy homeostasis and responses to ... -
Identification of expression quantitative trait loci (eQTL) and candidate genes associated with water holding capacity in porcine meat
Cinar, Mehmet Ulas (2011-01-19)Consumer assessment of meat quality is defined by the characteristics of sensory experience such as juiciness, muscle pH, water-holding capacity and colour. Water-holding capacity in terms of drip loss has a genetic as ... -
Identification of functional markers for detecting vision loss in early and intermediate age-related macular degeneration
Pondorfer, Susanne Gunda (2020-07-06)Patients in the early and intermediate stages of age-related macular degeneration (AMD) often perform well in conventional visual function tests under high luminance and high contrast, whereas testing under dim light and ... -
Identification of genetic factors involved in the regulation of stress
Barth, Alexander (2012-08-29)In this QTL mapping study, several genetic regions were linked to anxiety- and depression-related behavior in the mouse. Furthermore, some previously identified QTL linked to these behavioral traits were verified in the ... -
Identification of Genetic Risk Variants for the Development of Gastric Adenocarcinoma
Heß, Timo (2023-03-07)Gastric cancer (GC) is a clinically heterogeneous and one of the most common malignant tumour entities affecting the human gastrointestinal tract with a multifactorial aetiology. Beside environmental risk factors, also ... -
Identification of Genomic Alterations in Castration Resistant Prostate Cancer using Next Generation Sequencing
Menon, Roopika (2014-01-03)Castration resistant prostate cancer (CRPC) is the most aggressive form of prostate cancer (PCa). For the development of novel therapeutic targets for CRPC, it is key to decipher the molecular alterations underlying this ... -
Identification of hadronic τ decays using the τ lepton flight path and reconstruction and identification of jets with a low transverse energy at intermediate luminosities with an application to the search for the Higgs boson in vector boson fusion with the ATLAS experiment at the LHC
Ruwiedel, Christoph (2010-07-01)Three studies of different components of the object reconstruction with the ATLAS experiment using simulated data are presented. In each study, a method for the improvement of the reconstruction is developed and the ... -
Identification of host genes with a role in sex determination of the plant parasitic cyst nematode, Heterodera schachtii
Anjam, Muhammad Shahzad (2017-07-03)Cyst nematodes are biotrophic parasites that infect plant roots and cause physiological and structural modifications leading to the formation of syncytial nurse cells. They are sexually dimorphic but the sexual phenotype ... -
Identification of Intracellular Protein Binding Partners of Cisplatin and Their Role in Acquired and Intrinsic Resistance
Möltgen, Sophie (2021-03-18)Cisplatin is a widely used drug in treatment of various solid tumors, amongst others ovarian cancer. However, whereas acquired resistance significantly limits therapy success, some tumors such as colorectal cancer are ... -
Identification of low-valent iron-porphyrins: Electronic structure and reactivity towards CO2 reduction
Tarrago, Maxime (2022-01-25)The need to close the carbon cycle becomes urgent as concentration of CO2 in the earth atmosphere increases exponentially. Electrochemically-mediated conversion of CO2 into biofuels is a possible ... -
Identification of new molecular targets and antibiotics as novel strategies against filarial infections: Characterization of lipid II biosynthesis in Wolbachia endobacteria
Meier, Kirstin Anne (2019-06-05)Wolbachia are obligate intracellular bacteria found in many arthropods and some filarial nematodes that are pathogenic in humans. The Wolbachia genomes are highly reduced, but encode proteins required for ... -
Identification of Novel Causative Genes for Colorectal Adenomatous Polyposis
Horpaopan, Sukanya (2015-02-26)In up to 50% of families with clinically verified adenomatous polyposis no germline mutations in the established genes APC and MUTYH can be identified during routine diagnostics although the presence of high numbers of ... -
Identification of novel cytosolic binding partners of the neural cell adhesion molecule NCAM and functional analysis of these interactions
Wobst, Hilke Johanna (2014-12-04)The neural cell adhesion molecule (NCAM) plays an important role during brain development and in adult brain. NCAM functions through interactions with several proteins leading to intracellular signal transduction pathways ... -
Identification of novel TAM receptor interacting proteins: Screening for novel ligands
Görgen, Simon (2019-02-07)The TAM receptors TYRO3, AXL, and MER are well characterized for their roles in cell proliferation and survival, phagocytosis, and inhibition of inflammation. The complexities of these TAM receptor responses imply a level ... -
Identification of Pharmacogenomic and Functional Biomarkers for Antidepressant Treatment Outcome in Patients-Derived Lymphoblastoid Cell Lines
Barakat, Abdul Karim (2023-03-29)Major depression is the most prevalent mental disorder worldwide. Pharmacological management of the disease is considered a cornerstone in treatment guidelines adopted by many industrialized countries. However, response ... -
Identification of plant recognition receptors for nematode derived molecular patterns
Wang'ombe, Mary Wanjiku (2019-01-24)Plant parasitic nematodes are pathogens of great economic importance causing major losses in various food crops world-wide. A reliable, effective and efficient control method is establishing resistant cultivars of which ... -
Identification of positional and functional candidate genes for meat and carcass quality in F2 Duroc x Pietrain resource population
Kayan, Autchara (2011-04-06)Five genes, AMBP, GC, PPP1R3B, TNC and IFI6, whose candidacy for meat and carcass quality traits arises from their trait-dependent differential expression and/or trait correlated expression, were selected for analysis. ... -
Identification of Potential Biomarkers for Depressive Disorders
Breitfeld, Jörg (2017-09-29)The understanding of the individual variability of depressive disorders is in urgent need of improvement which could be accelerated by identification of biomarkers for the diagnosis and treatment individualization of ... -
Identification of prostaglandin receptors in human ureters
Oll, Matthias (2014-07-10)Prostaglandins play an important role in ureteral obstruction, but the detailed expression profiles of the prostaglandin receptors (PTGER1, PTGER2, PTGER3, PTGER4, PTGFR) remain unknown in the different parts of the human ...