Browsing by Title
Now showing items 6534-6553 of 9814
-
Notwendigkeit und Umfang der postoperativen intensiv-medizinischen Überwachung von Patienten nach elektiven epilepsiechirurgischen Eingriffen
Bahna, Majd (2022-09-12)Hintergrund: Traditionell werden Patienten nach erfolgtem elektiven resektiven epilepsiechirurgischen Eingriff postoperativ auf einer (Neuro)-Intensivstation berwacht. Das Ziel der berwachung ist eine ... -
Novel and Bioactive Natural Products from the Marine-Derived Endophytic Fungi: Coniothyrium cereale, Phaeosphaeria spartinae and Auxarthron reticulatum
Moustafa, Mahmoud Fahmi Elsebai (2011-10-28)The main goal of this study was to discover novel natural products with pharmacological potential by employing various biotechnological methods. Marine fungi have been identified as a promising resource for such molecules. ... -
Novel aspects of TGFβ in human CD4+ T cell biology
Claßen, Sabine (2008)During this thesis, several novel aspects of TGFß in human CD4+ T cell biology were investigated. First, we were interested, which factors control the resting state of CD4+ T cells. Genome-wide ... -
Novel aspects regarding structural variability in membrane protein families by the example of tetraspanins
Reppert, Nikolas (2022-11-16)The work at hand focuses on structural variability in membrane protein families by the example of tetraspanins. The family of tetraspanins is found in almost all multicellular organisms and they play important roles in an ... -
Novel Heterobimetallic Manganese-Chromium and Rhenium-Chromium Complexes: Coordination, Cyclometallation, Benzannulation and Haptotropic Metal Migration
Dubarle Offner, Julien (2009-03-23)A characteristic property of transition metal π-complexes with polycyclic aromatic ligands is their ability to undergo haptotropic rearrangements; the metal fragment is considered as the moveable functional group that is ... -
Novel insights into mechanisms and selectivity of the heterotrimeric G protein inhibitors BIM-46187 and FR900359
Schmitz, Anna-Lena (2015-04-24)Selective silencing of Gα protein subfamilies by small molecules is of great value to explore the contribution of G protein signaling in physiology and disease. It also represents a new opportunity to treat diseases, such ... -
Novel lantibiotics from microbial genomes
Dischinger, Jasmin (2012-07-19)The discovery of antibiotics was one of the most important milestones in medicine and in the fight against infectious disease. Today, more than 80% of anti-infective drugs are natural or semi-synthetic compounds. Rapidly ... -
Novel magnetic nanoparticles: Size and surfactant effects on geometric and electronic structure, probed using X-ray Absorption Spectroscopy
Palina, Natalie (2005)The investigation of magnetic nanoparticles is of great interest for potential applications. Due to huge surface, the properties of nanoparticles deviate from those of bulk material. In order to understand and control these ... -
Novel Methods for Chiral Molecules in the Gas Phase and Neoteric Solvents
Blasius, Jan (2024-03-19)This thesis focuses on the development and application of computational methods for the calculation of infrared (IR) and vibrational circular dichroism (VCD) spectra in the gas and liquid phase, with special emphasis on ... -
Novel Methods for Molecular and Ionic Liquids: From Fundamentals to Applications as Electrolytes
Ingenmey, Johannes Carl Maria (2021-09-13)The trend towards sustainable technologies and processes requires the development of suitable solvents and electrolytes. In this regard, next to traditional molecular solvents, ionic liquids (ILs) are regarded as promising ... -
Novel Molecular Si(II) Precursors for Synthesis of the First Compounds with Metal-Silicon Triple Bonds
Chernov, Oleg (2012-09-27)NHC-adducts of reactive silylenes were isolated as crystalline thermally stable solids. The NHC-adducts of SiBr2 and SiI2 were prepared upon reduction of the corresponding NHC adducts of silicon ... -
Novel Nicotinic Acetylcholine Receptor Ligands based on Cytisine and Choline: Synthesis, In vitro Evaluation and Structure-Activity Relationships
Munoz, Lenka (2005)It has been long accepted that targeting nAChRs represent a pathway for the treatment of various CNS-related and non CNS-related disorders (e.g. Alzheimer's and Parkinson's disease, schizophrenia, depression, inflammation, ... -
Novel Nicotinic Acetylcholine Receptor Ligands based on Cytisine, Ferruginine, Anatoxin-a and Choline: In vitro Evaluation and Structure-Activity Relationships
Tilotta, Maria Cristina (2004)Nicotinic acetylcholine receptors (nAChRs), excitatory ligand-gated cation channels, are transmembranic allosteric proteins composed of five polypeptide chains. The subtype at the neuromuscular junction consists of α1, β1, ... -
Novel Search Techniques to Detect Pulsar Black Hole Binaries in Radio Observations
Balakrishnan, Vishnu (2022-02-21)Pulsars are rapidly rotating highly magnetised neutron stars that emit beams of electromagnetic radiation from their magnetic poles. These compact objects are unique as they are one of the densest forms of matter known in ... -
Novel Secondary Metabolites from Endophytic Marine-derived Fungi
Almeida, Celso (2011-02-22)The marine environment is distinguished by unique groups of organisms being the source of a wide array of fascinating structures. Marine microorganisms, such as fungi often occur associated with macroorganisms like algae, ... -
Novel Small Molecule Inhibitors Dissecting GEF-dependent and -independent Cytohesin Functions in Immune Cell Signaling
Novak, Nina Maria (2014-06-20)Cytohesins are guanine nucleotide exchange factors (GEFs) for the small GTPases of the ARF family. They play important roles in immune cell signaling, immune cell adhesion and migration and furthermore in non-immune insulin ... -
Novel vaccination strategies for CD4+ T cell immunotherapy of melanoma
Shridhar, Naveen (2019-09-06)Immunotherapy has emerged as a standard treatment modality in melanoma and many other cancers. While a lot is known about the anti-tumoral effector functions of CD8+ T cells, CD4+ T cells remain less well understood in ... -
NRF2 mediated oxidative stress response activity during early in vitro bovine embryo development
Amin, Ahmed Abdelsamad Zaki (2015-03-30)Overcoming oxidative stress is one of the various embryo challenges to survive under suboptimal conditions during in vitro production of bovine embryos. Thus, the present study aimed to examine the ability of preimplantation ... -
Nuclear export of single native mRNA molecules observed via light sheet fluorescence microscopy and transcriptional regulation of BR2.1 during heat-shock
Kaminski, Tim Patrick (2015-01-06)Eucaryotes store most of their genetic information in the nucleus. Parts of this information encode the amino acid sequence of proteins. To synthesize a protein according to the nucleotide sequence, first the corresponding ...