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Now showing items 7684-7703 of 9812
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The role of Cysteine-rich with EGF-like domains 2 in the maintenance of metabolic homeostasis and regulation of the unfolded protein response
Kern, Paul (2019-12-17)Das Ziel dieser Arbeit war es, die Rolle von Creld2 bei der Aufrechterhaltung der metabolischen Homöostase unter Normalbedingungen und bei der Regulation der UPR unter ER Stressbedingungen zu untersuchen. Metabolische ... -
The role of cytohesins and the ARNO-CNK1 complex in insulin signalling
Sieg, Christian (2018-09-26)The tight regulation of signalling cascades is of crucial importance for organisms in order to react to external stimuli and maintain homeostasis. Insulin signalling is a key metabolic pathway in vertebrates and dysregulation ... -
The role of cytohesins in the regulation of immune responses
Solomatina, Anastasia (2020-02-17)Cytohesins are guanine nucleotide exchange factors for adenosine diphosphate ribosylation factor (Arf) proteins and promote the switch of Arfs to the active GTP-bound form. Cytohesins have been shown in different in ... -
The role of diacylglycerol acyltransferase 1 in hepatic medium-chain fatty acid metabolism
Wunderling, Klaus (2020-01-28)Fatty acids form a class of important biomolecules, serving as essential elements of lipid molecules. Stored in triacylglycerol (TAG), the main constituent of plant oils and animal fats, they from an inseparable part of ... -
The role of duodenal innate lymphoid cells in familial adenomatous polyposis
Kaiser, Kim Melanie (2023-09-18)Familial adenomatous polyposis (FAP) is an inherited gastrointestinal tumor syndrome. Apart from colonic polyposis and colorectal cancer, the occurrence of duodenal adenomas is the most common intestinal manifestation of ... -
The role of endocannabinoid system in brain aging
Piyanova, Anastasia (2012-07-23)Endocannabinoid system has recently been shown to play a role in brain aging. Mice lacking cannabinoid CB1 receptors (CB1 receptor knockout, Cnr1-/- mice) show signs of accelerated aging specific to the brain and cognitive ... -
The role of endocannabinoid system in neuron-glial communication in the ageing and diseased brain
Ativie, Frank (2017-12-13)The endocannabinoid system has been implicated in the regulation of glial activity and progression of brain ageing. Mice constitutively or specifically lacking the cannabinoid receptor 1 (CB1) on neurons or GABAergic neurons ... -
Role of Endothelin-1 in the Brown Adipose Tissue
Löffler, Stefan Michael Jan (2021-06-22)ET-1 was shown to inhibit adipogenesis in murine mesenchymal stem cells derived from new-born brown adipose tissue in vitro and antagonism of Endothelin-1 (ET-1) signaling at the respective level of the Endothelin-1 receptor ... -
The Role of External Shocks in Emerging Market Crises
Brei, Michael (2008)The dissertation attempts in three essays to contribute to the research on emerging market crises. A particular focus is set on problems associated with sudden stops of capital inflows, which appear to have been the cause ... -
Role of Farmers’ Organizations in Agricultural Transformation in Africa: Overview of Continental, Regional, and Selected National Level Organizations
Kampmann, Willi; Kirui, Oliver K. (2021-02)This study analyzes the critical role played by farmers’ organizations (FOs) in transforming agriculture in Africa. Specifically, it provides an overview of the state of continental and regional FOs in Africa. It also ... -
The role of Four-and-a-half LIM domain protein 2 in dendritic cell migration
König, Katharina (2012-01-12)We identified the four-and-a-half LIM domain protein 2 (FHL2) as a novel regulator of CCL19-induced dendritic cell (DC) migration. Initiation of migration is a hallmark of DC function and plays a central role in the induction ... -
The role of GBA2 in controlling locomotor activity
Woeste, Marina Amelie (2018-12-13)Glycosphingolipids are major constituents of cellular membranes, fulfilling both structural and functional roles. Modifications of the basic glycosphingolipid glucosylceramide (GlcCer) result in numerous complex glycosylated ... -
The role of glial calcium changes in animal models of stroke
Rakers, Cordula Marijke (2015-12-04)Ischemic stroke represents one of the leading causes of death and disability. A main characteristic of the early phase of stroke is the spontaneous appearance of peri-infarct depolarizations (PIDs), which are known to ... -
Role of GluA2-containing AMPARs in Oligodendrocyte Lineage Cells
Faure, Vicky (2024-01-30)Oligodendrocytes precursor cells (OPC), also called NG2 cells, proliferate or differentiate into myelin-producing oligodendrocytes throughout life. Myelination depends on neuronal activity. Although NG2 cells receive ... -
The role of glutaredoxin S15 in the transfer of Fe–S clusters and their consumption by lipoyl synthase in Arabidopsis mitochondria
Pedroletti, Luca (2024-01-15)(noch nicht zugänglich / not yet accessible) -
The Role of Glycolipids at the Interface of PlantMicrobe Interactions during Nodulation and Mycorrhiza Formation in Lotus japonicus
Wewer, Vera (2013-04-09)Lipids are important constituents of plant membranes, which represent the interface of plant-microbe interactions. In the present work, the role of membrane lipids of Lotus japonicus during root-nodule symbiosis with the ... -
The role of GPR111 in adipose tissue
Zurkovic, Jelena (2021-05-21)Due to obesity pandemic and limited therapeutic approaches, novel targets of pharmaceutical treatments are urgently needed. AT as a very important metabolic organ is an attractive target for combating obesity and obesity ... -
The role of guanine nucleotide exchange factors (GEFs) in EGF-receptor signalling: Screening for a small molecule inhibitor of the Rin1-mediated Rab5 activation
Hamann, Maren (2018-06-04)The small GTPase Rab5 is a key regulator of early endosomal trafficking. It functions as a molecular switch that can be activated by guanine nucleotide exchange factors (GEFs) and inactivated via hydrolysis of GTP with the ... -
The role of guanine nucleotide exchange factors in the regulation of immune cell signaling
Grell, Jessica (2009-07-08)The ARF GEF cytohesin-1 was originally identified as β2-integrin binding protein, and was shown to play an important role in the control of integrin-dependent immune cell migration and adhesion via activating the small ... -
The Role of High-Salt Diet on Melanoma Growth
Stumpf, Natascha Ellen (2024-03-04)Cutaneous melanoma is one of the most aggressive cancer types in Western countries with a rising incidence over the last decades. Treatment of early-diagnosed melanoma constitutes a good survival rate and recovery. However, ...