Auflistung nach Titel
Anzeige der Dokumente 8344-8363 von 9814
-
Structural and Functional Characterization of Human Transcription-regulating Kinases
(2024-03-12)(noch nicht zugänglich / not yet accessible) -
Structural and Functional Characterization of Neurotoxic Oligomers of Pro-aggregant Tau Repeat Domain: A model for Tauopathy disease
(2016-04-26)Tau protein is a microtubule associated protein present abundantly in the neurons of the central nervous system where it stabilizes the axonal microtubules thereby providing structural architecture for the axons of neurons. ... -
Structural and functional characterization of the HPV16 entry platform on the cell surface
(2020-12-16)Human papillomaviruses (HPV) are small, non-enveloped DNA viruses that infect skin and mucosa tissues. Among the family, HPV16 is one of the most oncogenic subtypes responsible for a variety of cancers, including cervical, ... -
Structural and functional characterization of TRAP transporters from bacterial pathogens
(2021-08-26)The class of tripartite ATP-independent periplasmic (TRAP) transporter proteins are wide-spread in the kingdoms of prokaryotes and archaea, where they are responsible for translo-cation of substrates across the cell membrane. ... -
Structural and functional principles of long-range connectivity in the rat vibrissal system
(2020-11-05)Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Integrating feedforward thalamo-cortical (TC) and recurrent intracortical (IC) inputs with those from top down cortical-cortical ... -
Structural and functional promoter analyses of epilepsy-relevant genes as basis for targeted expression interference
(2023-07-21)Background: Epilepsies are a group of brain disorders characterized by recurrent seizures. A fraction of those has a well defined genetic aetiology including monogenic epilepsies, and others are the result ... -
Structural aspects of the plasmalemmal Amyloid Precursor Protein cluster
(2021-11-12)Alzheimer’s Disease (AD) is a major socio-economic threat to health care systems and society in general. Involvement of the amyloid-beta peptide (Aβ) and its parent, the amyloid precursor protein (APP), in AD seemed obvious ... -
Structural conformational analysis of molecular dynamics of a P-glycoprotein homology model and generated intermediate structures
(2019-10-02)The major reason for failure of chemotherapy in cancer is multidrug resistance. A mechanism by which human cancers develop multi-drug resistance is over expression of certain ATP-binding cassette (ABC) transporters. ... -
Structural remodeling of L-type calcium channel subunits in human and murine atherosclerosis
(2012-12-13)The function of voltage-gated L-type calcium channels (LTCCs) has major impact on the function and contractility of vascular smooth muscle cells (VSMCs). The influx of external calcium regulates intracellular free calcium ... -
Structural transformation and labour market development in Sub-Saharan Africa: Evidence from Ghana and Nigeria
(2023-09-13)The thesis examines the changing economic and employment structure in Sub-Saharan Africa by focusing on Ghana and Nigeria. It is structured into an introduction and four main chapters, each answering specific research ... -
Structure and function study of HCN1 channel by forming a lattice on the membrane
(2020-09-08)Hyperpolarized-activated cyclic nucleotide-gated (HCN) channels play complex and diverse roles in the regulation of neuronal and network excitability. Aberrant expression, trafficking, and post-translational modifications ... -
Structure in galaxy clusters revealed through Sunyaev-Zel’dovich observations: A multi-aperture synthesis approach
(2014-12-02)As the largest bound objects in the universe, galaxy clusters are unique targets to study astrophysical processes, as well as powerful probes for precision cosmology. Galaxy clusters are dynamically young and their merger ... -
The structure of massive star-forming clumps
(2021-11-25)Among many other critical questions in astrophysics, the high-mass star formation process is a matter of heated debate; so far a comprehensive understanding is lacking. Star formation takes place in cold molecular clouds. ... -
Structure-directing effects in microheterogeneous ionic liquids
(2023-02-08)The man-made climate change and contamination of the world's oceans with plastics demand for the development of alternative solvents, in particular to establish more efficient material synthesis routes and extraction ... -
Structures, possibilities and limits of European crisis reaction forces for conflict prevention and resolution: conditions for a successful EU security and defence policy, based on the decisions by the EC at Nice 9th December 2000
(2001)The following paper is based on the author’s “Conditions and options for an autonomous ‘Common European Policy on Security and Defence’ in and by the European Union in the post-Amsterdam perspective opened at Cologne in ... -
Struggling to find a recipe for peace - Ten years of European initiatives to End the conflict in Syria
(2021)Auch zehn Jahre nach Beginn des Syrien-Konfliktes ist die EU führender Geber von humanitärer Hilfe. In ihrem militärischen Engagement ist sie jedoch weiterhin zögerlich und ringt darum, vor Ort Frieden herzustellen. Es ... -
Struktur und Entwicklung der Versorgung psychiatrischer Patienten: Ein Vergleich zwischen Deutschland und Finnland
(2015-04-14)In der vorliegenden Arbeit werden strukturelle Unterschiede sowie die Entwicklung der psychiatrischen Versorgungssysteme zwischen den Industrieländern Deutschland und Finnland mit Methoden der qualitativen Sozialforschung ... -
Struktur und Reaktivität der reinen und modifizierten Pd(111)-Elektrodenoberfläche
(2009-08-26)Bisher wurde in der Literatur ein widersprüchliches Adsorptionsverhalten von Kohlenmonoxid auf der Pd(111)-Oberfläche zwischen UHV und wässrigen Lösungen bei Raumtemperatur beschrieben: Während im UHV gemessene IRRAS-Spektren ... -
Struktur- und Arbeitsmarktziele der Ruhrgebietsstädte: Eine politisch-geographische Analyse von Handlungskonzepten der kommunalen Wirtschaftsförderung
(1993)Mit dem Staat als zentralem Objektbereich hat die Politische Geographie bis heute eine Integration der kommunalpolitischen Ebene weitgehend vernachlässigt. Neben konflikttheoretischen Ansätzen und marxistisch orientierten ... -
Struktur- und Funktionsanalyse von Ataxin-2 mittels bioinformatischer Methoden
(2006)Die Spinozerebelläre Ataxie Typ 2 (SCA2) ist eine autosomal-dominant vererbte, neurodegenerative Erkrankung. Verursacht wird sie durch eine verlängerte Glutaminkette (PolyQ-Kette) im 5´ Ende (coding Region) des Exons 1 auf ...
