Browsing by Author "Wagner, Karl Gerhard"
Now showing items 1-9 of 9
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Application of Sensitive API-Based Indicators and Numerical Simulation Tools to Advance Hot-Melt Extrusion Process Understanding
Evans, Rachel Catherine (2019-09-11)This dissertation explored the use of active pharmaceutical ingredients (APIs) as indicator substances as well as numerical process simulation to enhance process understanding of hot-melt extrusion (HME) in the pharmaceutical ... -
Design, Entwicklung und Herstellung modifizierter gastroretentiver schwimmender Systeme auf Basis von schmelzextrudierten hohlen Zylindermatrices
Simons, Fabian Josef (2020-04-15)Die Entwicklung gastroretentiver Arzneiformen ist komplex, da neben der kontrollierten Freisetzung des Wirkstoffs zusätzlich die Verlängerung der Verweilzeit im Magen gewährleistet werden muss. Hierfür werden meist hydrophile ... -
Development of protein loaded microparticles and nanoparticles for antigen delivery
Francis, Donny (2014-12-12)An innovative approach of developing modern adjuvants is the design of particulate antigen delivery systems. These, typically polymeric, particles that are in a size range of micro- and nanoparticles can be used as drug ... -
Dry granulation via roller compaction: investigation on scale up strategies integrating process parameters and critical material attributes
Schmidtke, Robert (2018-05-23)Granulation processes for solid oral dosage forms are commonly used in the pharmaceutical industry to enhance the quality of the final product, i.e. tablets. Today, roller compaction is one of the most common granulation ... -
Entwicklung von Mikropartikeln für parenterale Depotarzneiformen mit biologischen Wirkstoffen
Buske, Julia (2013-03-07)Das Ziel der vorliegenden Arbeit war die Entwicklung und Implementierung einer Plattformtechnologie zur Herstellung von Mikropartikeln auf Basis bioabbaubarer Polymere als Depotarzneiform für therapeutisch-anwendbare ... -
Investigation and Optimisation of the Presster: A Linear Compaction Simulator for Rotary Tablet Presses
Neuhaus, Thorsten (2007)Tablets are currently the most frequently used pharmaceutical dosage form. Development of new tablet formulations is performed on both eccentric and lab scale rotary tablet presses.
Differences in the working principle ... -
Model-based formulation of amorphous solid dispersions made by hot-melt extrusion
Bochmann, Esther Sophia (2019-08-21)Regarding hot-melt extrusion in early pharmaceutical formulation and process development, techniques and procedures are needed to simplify the application of hot-melt extrusion (HME) and to decrease the effort in terms of ... -
Nanocarrier system for overcoming multidrug resistance in cancer
Singh, Manu Smriti (2015-02-04)Of all the cases, majority of cancer patients respond to therapeutic interventions transiently or incompletely. These multidrug resistant (MDR) cancer cases are either resistant to chemotherapy or acquire resistance during ... -
Vacuum drum drying: a novel technology for enabling formulation principles in the development of oral solid dosage forms
Schönfeld, Barbara Veronika (2022-11-21)The present work demonstrates the applicability of vacuum drum drying (VDD) as novel technology in the development of solid, oral dosage forms for two enabling formulation principles: a) manufacture of amorphous solid ...