Auflistung nach Schlagwort "Inflammasome"
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Die Aktivierung des NLRP3 Inflammasoms durch RAN Peptide beim Morbus Huntington
(2023-08-29)Neuroinflammation als ein treibender Faktor der Pathologie verschiedener neurodegenerativer Erkrankungen spielt auch in der Pathologie von HD eine relevante Rolle. Durch die Entdeckung von RAN Translation, einem Mechanismus ... -
Biochemical and structural characterization of the NLRP3 inflammasome
(2020-02-13)The innate immune system utilizes inflammasome proteins to recognize danger signals and to fight invading pathogens. To date, the most studied inflammasome protein is NLRP3 - a multidomain protein, composed of a N-terminal ... -
Biochemical and structural studies of NOD-like receptors and their inhibition by small molecule inhibitors
(2023-03-07)NOD-like receptors (NLRs) are innate immune sensors that can form inflammasomes driving pyroptosis. NLRP3 is the best studied member of the NLRs to date, and its dysregulation has been linked to human diseases relevant to ... -
Investigating the molecular basis of human NLRP1 inflammasome activation
(2020-03-10)Cytosolic sensor proteins like NLRP1 (NOD-like receptor containing a pyrin domain 1) play a fundamental role in mediating innate immunity. Upon activation they form signalling hubs that recruit the adaptor protein ASC ... -
Return of the first inflammasome: Elucidation of NLRP1 inflammasome activation by p38-mediated phosphorylation and ubiquitination
(2024-01-30)The assembly of inflammasomes is linked to the detection of pathogens and other danger signals by intracellular pattern-recognition receptors of the mammalian innate immune system. The human inflammasome sensor NLRP1 is ... -
The role of cysteines and S-palmitoylation in NLRP3 inflammasome activation
(2025-07-15)Nucleotide oligomerization domain (NOD)-like receptor protein 3 (NLRP3) is a cytosolic pattern recognition receptor with a critical role in numerous autoinflammatory disorders and non-communicable diseases characterized ... -
Toward a precision medicine in Alzheimer’s Disease: blood phenomic fingerprint for diagnostic and therapeutic developments
(2020-05-05)There is an unmet clinical need to identify reliable blood biomarkers for Alzheimer’s Disease (AD) that can be used for diagnostics and therapeutic purposes.<br /> The complex nature of AD, single-readout approaches ...
