Publikationen

Mesiodistal width correlation between primary and successor mandibular teeth

2025-09-24T00:00:00Z

Mesiodistal width correlation between primary and successor mandibular teeth Cakir, Aleyna; Both, Annika; Kirschneck, Christian; Daratsianos, Nikolaos; Miranda de Araújo, Cristiano; Corá, Juliane; Calvano Küchler, Erika; Beisel-Memmert, Svenja Grassia, Vincenzo Background: Most studies on permanent tooth width prediction focus on the predictive value of permanent teeth, however only a few studies examine the predictive value of primary teeth. The aim of this study was to investigate the correlation between the mesiodistal widths of the mandibular primary canines and molars and those of their permanent successors. In addition, the study evaluated whether the mesiodistal width of the primary canines and molars can serve as reliable predictors for the width of the permanent mandibular first molars.
Methods: This cross-sectional study analyzed records from 143 orthodontic patients (78 males and 65 females) who had digitized dental models in the mixed and in the permanent dentition stage. Mesiodistal measurements were performed on left-sided mandibular permanent teeth (canines, first and second premolars, first molar), and primary teeth (canines, first and second molars). The Pearson correlation coefficient test was used to determine the correlation strength between the mesiodistal dimensions of primary and permanent teeth (p < 0.05).
Results: Significant correlations were found between second primary molars and second premolars (Pearson r = 0.400–0.461) as well as between primary and permanent canines (Pearson r = 0.462–0.512), across the total sample and within both sexes. The dimensions of all three evaluated primary teeth were correlated with first permanent molar with r ranging from 0.402 to 0.625. The primary first molar showed a weak correlation with the first premolar for the total sample (Pearson r = 0.240) and males (Pearson r = 0.302), and none was observed for female patients (Pearson r = 0.048).
Conclusions: A link between primary and permanent tooth width of canines and posterior dentition was observed, but a difference between sexes exists. Therefore, primary teeth may offer early insight into future space requirements, however their predictive strength is influenced by tooth type and sex.

Fibroblast growth factor receptor 2 (FGFR2) genetic polymorphisms contribute to fused roots in human molars

2025-04-10T00:00:00Z

Fibroblast growth factor receptor 2 (FGFR2) genetic polymorphisms contribute to fused roots in human molars Santos Meyfarth, Sandra Regina; Baratto-Filho, Flares; Nunis Locks, Maria Eduarda; Proff, Peter; Oliveira Zandoná, Giordano; Oliveira Fernandes, Thaís de; França, Paulo Henrique Condeixa de; Kirschneck, Christian; Antunes, Leonardo Santos; Calvano Küchler, Erika Fibroblast growth factors (FGFRs) signaling are required for human tooth development. Its dysregulation affects tooth formation and patients with FGFR2 mutations often present dental anomalies in the spectrum of the syndrome. This study aimed to investigate whether genetic polymorphisms in FGFR2 are associated with molar fused roots. The null hypothesis is that genetic variations in FGFR2 are not associated with isolated cases (non-syndromic) of molars fused roots. Panoramic radiographs of non-syndromic patients were used to assess the occurrence of fused roots in molars. Genomic DNA analysis was performed to investigate polymorphisms within the candidate gene. The association between fused roots and genetic polymorphisms was analyzed using allelic and genotypic distributions, and haplotype frequencies. Odds ratio and 95% confidence interval were calculated to assess the chance of presenting fused roots. The significance level was set at p < 0.05 for all the analysis. A total of 170 patients were included. Statistically significant differences in genotype distribution were observed in rs10736303 and rs2162540. Individuals carrying at least one G allele of rs10736303 had an increased chance to present fused roots. A total of 154 haplotype combinations demonstrated statistically significant associations. The polymorphisms rs10736303 and rs2162540 in FGFR2 were associated with fused roots in human molars.

Demirjian's and Cameriere's Methods for the Assessment of Dental Age Estimation in Children from a Southern Brazilian City

2024-07-13T00:00:00Z

Demirjian's and Cameriere's Methods for the Assessment of Dental Age Estimation in Children from a Southern Brazilian City Carelli, Julia; Sabrina da Silva, Gabriela; Vegini Gomes, Mariana; Vilalba, Thais; Baratto-Filho, Flares; Brancher, João Armando; Beisel-Memmert, Svenja; Kirschneck, Christian; Condeixa de França Lopes, Celia Maria; Moro, Alexandre; Calvano Küchler, Erika The chronological age estimation of living individuals is a crucial part of forensic practice and clinical practice, such as in orthodontic treatment. It is well-known that methods for age estimation in living children should be tested on different populations. Ethnic affiliations in Brazil are divided into several major groups depending on the region, with the south of Brazil being known for its German immigration. (1) Background: This study aimed to evaluate the correlation between chronological age and dental age using Demirjian's method and Cameriere's method in a group of children from Joinville, South Brazil to investigate if both methods can be used to estimate dental age in this population. (2) Methods: The sample consisted of 229 panoramic radiographs (119 were males and were 110 females) from Brazilian children (ages ranging from 6 to 12 years). The chronological age at the time of the panoramic radiographic exam was calculated for each child. The dental age was estimated according to Demirjian's method and Cameriere's method. All continuous data were tested for normality by using the Shapiro–Wilk test. The Pearson correlation coefficient test was applied. An alpha of 5% (p < 0.05) was used for all analyses. (3) Results: The mean chronological age was 8.75 years. According to Demirjian's method, the mean dental age was 9.3 years, while according to Cameriere's method, the mean dental age was 8.66 years. A strong correlation between chronological age and dental age according to Demirjian (r = 0.776 and p < 0.0001) and Cameriere (r = 0.735 and p < 0.0001) was observed for both genders. (4) Conclusions: Both methods presented a good correlation with chronological age in the studied population and could be used to assess dental age in this population.