Weller, Johannes; Lampmann, Tim; Asoglu, Harun; Schneider, Matthias; Ehrentraut, Stefan Felix; Lehmann, Felix; Güresir, Erdem; Dorn, Franziska; Petzold, Gabor; Vatter, Hartmut; Zimmermann, Julian: Additive prognostic impact of the cerebrospinal fluid arginine/ornithine ratio to established clinical scores in aneurysmal subarachnoid hemorrhage. In: Frontiers in Neurology. 2023, vol. 14, 1-6.
Online-Ausgabe in bonndoc: https://hdl.handle.net/20.500.11811/10801
@article{handle:20.500.11811/10801,
author = {{Johannes Weller} and {Tim Lampmann} and {Harun Asoglu} and {Matthias Schneider} and {Stefan Felix Ehrentraut} and {Felix Lehmann} and {Erdem Güresir} and {Franziska Dorn} and {Gabor Petzold} and {Hartmut Vatter} and {Julian Zimmermann}},
title = {Additive prognostic impact of the cerebrospinal fluid arginine/ornithine ratio to established clinical scores in aneurysmal subarachnoid hemorrhage},
publisher = {Frontiers},
year = 2023,
month = apr,

journal = {Frontiers in Neurology},
volume = 2023, vol. 14,
pages = 1--6,
note = {Cerebrospinal fluid (CSF) metabolites are increasingly recognized as prognostic factors in aneurysmal subarachnoid hemorrhage (SAH). The CSF arginine/ ornithine ratio (Arg/Orn) was shown to predict cerebral vasospasms and clinical outcome in SAH. The additive prognostic value of Arg/Orn over established prognostic scores has not been investigated. CSF Arg/Orn and the established prognostic scores SAH, FRESH, SAH-PDS, HAIR, Rosen–McDonald, Hunt and Hess, WFNS and modified Fisher scale were determined in a prospective cohort of patients with aneurysmal SAH. Logistic regression models to predict a favorable outcome, defined as a modified Rankin Scale score of 0–3 at 3 months follow- up, were constructed for each score, both with and without the addition of Arg/ Orn. The impact of Arg/Orn was assessed comparing logistic regression models containing the respective score with and without Arg/Orn with the likelihood ratio chi-squared test. CSF Arg/Orn and clinical scores were determined in 38 SAH patients. Arg/Orn was an independent predictor of clinical outcome when added to established prognostic scores (p < 0.05) with the exception of HAIR (p=0.078). All models were significantly improved if Arg/Orn was added as a covariable (p<0.05). The results of this study confirm Arg/Orn as an independent prognostic factor and its addition improves established prognostic models in SAH.},
url = {https://hdl.handle.net/20.500.11811/10801}
}

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