The Faculty of Mathematics and Natural Sciences: eDissertationen
Recent Submissions
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Small Molecules, Big Impact: Investigating Hydrides in the Interstellar Medium
(2021-06-16)This thesis investigates hydride molecules in the interstellar medium (ISM) and their use as diagnostics of different phases of the ISM. Particular emphasis is given to the central CH radical, a probe of diffuse and ... -
Bridging between data and knowledge: New ways to better understand Alzheimer's Disease and Type 2 Diabetes comorbidity
(2021-06-15)The holistic understanding of biological phenomena enabled by systems biology forms the basis of current research. As opposed to the principle of classical biology where behavior of a biological system is explained by ... -
The Role of microRNAs in the Regulation of Human UDP-glucuronosyltransferases (UGTs)
(2021-06-14)The liver is involved in endo- and xenobiotic metabolism due to the expression of drug-metabolizing UDP-glucuronosyltransferases (UGTs). By UGT-mediated elimination of hazardous compounds and other reactive metabolites, ... -
Mass spectrometric analysis of short-lived intermediates and ancient fossils
(2021-06-14)(noch nicht zugänglich / not yet accessible) -
A reporter cell system for TREM2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region
(2021-06-08)(noch nicht zugänglich / not yet accessible) -
Hydroxylation of ectoine and synthetic ectoine derivatives via E. coli-mediated whole-cell biotransformation
(2021-06-07)The compatible solutes ectoine and hydroxyectoine are compounds mainly produced by halophilic organisms in order to prevent the loss of intracellular water when exposed to high osmotic pressure. Furthermore, these substances ... -
Investigations into side chain assembly and attachment during biosynthesis of the G protein inhibitor FR900359
(2021-06-07)The natural product FR900359 (FR) selectively inhibits Gaq proteins and thus intracellular signalling of many G protein-coupled receptors. This unique mechanism of action makes FR an indispensable pharmacological tool to ... -
Semantic Question Answering Over Knowledge Graphs: Pitfalls and Pearls
(2021-06-07)Nowadays, the Web provides an infrastructure to share all kinds of information which are easily accessible to humans around the world. Furthermore, the amount of information is growing rapidly and requires computing machines ... -
The chromatin organizer Satb1 regulates the differentiation into CD4+ TH subsets and is essential for the development of TH17 cells
(2021-06-04)(noch nicht zugänglich / not yet accessible) -
Towards Complex Question Answering over Knowledge Graphs
(2021-06-02)Over the past decade, Knowledge Graphs (KG) have emerged as a prominent repository for storing facts about the world in a linked data architecture. Providing machines with the capability of exploring such Knowledge Graphs ... -
Embeddings of groups rings and L2-invariants
(2021-06-02)The strong Atiyah conjecture for a group G, which restricts the possible values taken by L2-Betti numbers of G-CW-complexes, implies far-reaching structural statements about a canonical *-regular ring RℚG, ... -
Similarities and Representations of Graph Structures
(2021-06-01)Graphs are a natural representation for diverse systems ranging from social networks to the Web and brain structure. Even when data is not interconnected explicitly, it is often convenient to convert it into a graph for ... -
Histidine and Tyrosine-based Heme-binding Motifs for the Prediction of Heme-Regulated Proteins
(2021-06-01)(noch nicht zugänglich / not yet accessible) -
Geometric three-dimensional modelling of tectonic structures in the Alps and Jura Mountains
(2021-06-01)Geometric and kinematic three-dimensional (3D) modelling of complex geological structures experienced an outstanding evolution and has become more and more important nowadays in the field of geoscience as well as oil and ... -
Untersuchung der molekularen Mechanismen einer intrinsischen sowie Matrix-vermittelten Cisplatinresistenz in W1 Ovarialkarzinomzellen
(2021-06-01)Die Resistenzbildung von Tumoren gegen antineoplastische Medikamente bildet das Haupthindernis der klinischen Behandlung von Krebserkrankungen und unterstreicht die dringende Notwendigkeit, innovative Therapien zu entwickeln. ... -
Comparative Analysis of Open Linked Fiscal Data
(2021-06-01)The open data movement within public administrations has provided data regarding governance publicly. As public administrators and governments produce data and release the data as open data, the volume of the data is highly ... -
Influence of disulfide-bonds on structural and functional properties of peptides and proteins - Case studies on FXIIIa inhibitor tridegin and µ-conotoxin PIIIA
(2021-05-28)Disulfide-bonded peptides have been studied for many decades serving as tools to investigate various biochemical pathways as well as lead structures for drug development for numerous diseases. Among these, the most fatal ... -
Characterization of signaling events following single-cell death in myocardial cell clusters in vitro
(2021-05-26)Cell death is a characteristic feature of acute and chronic cardiac pathologies such as myocardial infarction, ischemia-reperfusion and heart failure. Cardiomyocytes (CMs) death triggers myocardial remodeling that may lead ... -
Exploring Non-Equilibrium in Ultracold Fermi Gases and Machine Learning in Physics
(2021-05-21)This thesis covers two fields of research carried out in the context of ultracold Fermi gases: Non-equilibrium physics in the BEC-BCS crossover and the use of machine learning methods in physics.
The BEC-BCS ... -
Etablierung und Optimierung eines Produktionssystems zur Synthese des alternativen Süßstoffs 5-Ketofruktose in Gluconobacter-Stämmen
(2021-05-21)Übergewicht, Adipositas und Diabetes sind in der heutigen Gesellschaft längst keine seltenen Krankheiten mehr. In den letzten Jahrzehnten hat die Prävalenz dieser Erkrankungen enorm zugenommen und kann mit einer zuckerreichen ...
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