E-Dissertationen: Auflistung E-Dissertationen nach Titel
Anzeige der Dokumente 1419-1438 von 4067
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Function of Cytoplasmic FMR1-interacting protein 2 (CYFIP2) in spinal motor neuron morphology during mouse embryonic development
Hauck, Stefanie Carla Rosa (2022-06-03)The development of the nervous system is a tightly regulated spatio-temporal process that involves actin cytoskeletal dynamics. The remodelling of the neuronal cytoskeleton is important for dendritic and axonal guidance, ... -
Function of Reelin Signaling in the Tangential Migration of Dopaminergic Neurons
Vaswani, Ankita Ravi (2021-01-07)Midbrain dopaminergic neurons (mDA neurons) are involved in the regulation of voluntary movement, reward behavior and cognitive processes. mDA neurons are born in the floor plate of the ventral midbrain, from where they ... -
Function of RIM4 in cerebellar circuits
Breithausen, Eva Maria (2023-12-18)(noch nicht zugänglich / not yet accessible) -
Function of the Cytoplasmic FMRP Interacting Protein 1 (CyFIP1) in mouse
Stöcker, Stefanie (2016-04-26)CyFIP (Cytoplasmic Fragile X mental retardation protein Interacting Protein) is a large scaffolding protein that was shown to be a central regulatory component of the WAVE complex. The pentameric WAVE complex is a nucleation ... -
Functional in vivo calcium imaging in the hippocampus under healthy and disease conditions
Mittag, Manuel (2020-04-22)The hippocampus has long been known to be essential for all features of memory processing. Hippocampal function strongly depends on the orchestrated activity of transiently autonomous neuronal populations that create the ... -
Functional analyses of the conserved Cysteine-rich with EGF-like domains (Creld) protein family in Mus musculus
Mass, Elvira (2014-03-28)The Cysteine-rich with EGF-like domains (Creld) protein family is highly conserved between species. However, its physiological function remained elusive. Using Creld1 knock-out (Creld1KO) mice, Creld1 was identified ... -
Functional analysis of microglial signal regulatory protein β 1 (SIRPβ1)
Gaikwad, Sadanand (2007)Microglial cells are the resident macrophages of the central nervous system (CNS) and thus form the interface between the neural parenchyma and the immune system. Although little is known about microglia in the CNS, it is ... -
Functional analysis of molars in “symmetrodontan” mammals
Plogschties, Thorsten (2020-03-10)The “symmetrodontan” molar pattern is characterized by triangulation of the main cusps in combination with a reversed-triangle occlusion. In the fossil record, the “symmetrodontan” molar pattern occurred in various taxa ... -
Functional analysis of the endocannabinoid system in conditional mouse mutants
Schüle, Lena-Louise (2020-09-04)In the scope of this thesis conditional knockout mice with a cell-specific deletion of Dagla (diacylglycerol lipase alpha) in neurons, astrocytes or microglia cells were generated, in order to identify the cellular source ... -
Functional Analysis of the Xin-Repeat Protein Family in Cross-striated Muscle
Eulitz, Stefan (2011-11-29)The assembly of the sarcomere of cross-striated muscle involves a plethora of transcription factors, signalling and structural proteins and requires their coordinate interplay in order to construct this uniquely regular ... -
Functional and Mechanical in vitro Analyses of the Mammary Gland Basement Membrane as a Barrier During Cancer Invasion
Gaiko-Shcherbak, Aljona (2019-04-30)Among women, breast cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths worldwide. Despite extensive research, the processes involved in invasion of malignant breast cancers are still not ... -
Functional characterisation of glutaredoxin S15 from Arabidopsis thaliana
Moseler, Anna Maria (2017-12-13)Iron-sulfur clusters (ISCs) are essential cofactors that are composed of iron and inorganic sulfur. A complex assembly pathway conveys their initial synthesis and subsequent binding to the respective apoproteins. With the ... -
Functional characterisation of the mitochondrial Hsp70 cochaperone Zim17
Lewrenz, Ilka (2013-09-23)The mitochondrial zinc finger protein Zim17 belongs to a newly identified class of cochaperones that maintain the function of Hsp70 proteins in mitochondria and plastides of eukaryotic cells, presumably by preventing the ... -
Functional characterization of Cytoplasmic Polyadenylation Element Binding proteins in the developing and diseased brain
Skubal, Magdalena (2016-12-22)Gliomas are the most common primary brain tumors with aggressive progression and devastating prognosis. Therefore identification of new therapeutic and diagnostic factors is necessary to improve the dramatic situation of ... -
Functional characterization of Gαi/s proteins and modulation of their activity by linear and cyclic peptides
Pepanian, Anna (2024-01-30)Heterotrimeric Gαβγ (guanine nucleotide-binding) proteins serve as molecular switches to activate (“switch on”) or inactivate (“switch off”) diverse intracellular signaling cascades in response to stimulated G protein-coupled ... -
Functional Characterization of Interaction Partners of the Co-Chaperone BAG3
Zeidler, Claudia (2018-04-23)Protein homeostasis (proteostasis) describes the cellular balance between protein synthesis, function and degradation. The stress inducible co-chaperone BAG3 is a key factor in proteostasis, in particular under mechanical ... -
Functional characterization of neuron-NG2 cell synaptic transmission
Paßlick, Stefan (2014-09-11)NG2 cells are nowadays considered as a fourth class of glial cells in the CNS. They express various types of voltage-gated ion channels and neurotransmitter receptors and exhibit the capability to proliferate and differentiate. ... -
Functional characterization of the 5-oxo-ETE receptor OXE-R and identification of the first small molecule antagonist with a novel mechanism of ligand bias
Blättermann, Stefanie (2011-10-21)The lipid mediator 5-oxo-ETE (OXE) is a metabolite of the 5-lipoxygenase pathway and acts as a potent chemoattractant on eosinophils and neutrophils. OXE-induced effects are mediated via the Gi coupled 5-oxo-ETE ... -
Functional characterization of the synaptic-activity regulated gene Synaptotagmin10
Woitecki, Anne Maria Helena (2013-12-10)During epileptogenesis multiple cellular and molecular changes occur in the brain resulting in the emergence of recurrent spontaneous seizures. One member of the Synaptotagmin (Syt) gene family that is rapidly and transiently ... -
Functional Characterization of Transgenic Arabidopsis thaliana Plants Co-over expressing Aldehyde dehydrogenases and Genes for Soluble Osmolytes
Raza, Hasnain (2010-09-16)Plant growth and productivity is largely hampered by a number of abiotic stresses. These stresses affect the physiological and metabolic pathways leading to the production of many harmful substances like aldehydes, reactive ...