eDissertationen: Browsing eDissertationen by Title
Now showing items 1630-1649 of 3481
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Investigation of polyketide biosynthetic pathways in the sponge Theonella swinhoei and the beetle Paederus fuscipes
(2009-12-14)Onnamides are natural products that possess strong antitumor activity and were isolated from the marine sponge Theonella swinhoei. Previous data suggested that an as-yet unculturable symbiotic bacterium living in ... -
Investigation of Quinazoline Derivatives as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)
(2018-03-12)The treatment of cancer with chemotherapeutic drugs is strongly limited by intrinsic or aquired resistance of the cancer cells. This is the main reason of a failure of the therapy. The cellular resistance mostly originates ... -
Investigation of riboswitches as new antibacterial targets: Identification and characterization of novel synthetic and natural riboswitch modulators with effect on bacterial cell growth
(2013-01-24)The increase in bacterial resistances and the decrease in available antibacterial substances against multi-drug resistant pathogens calls for an intensified search for novel antibiotics. Therefore, in this study riboswitches ... -
Investigation of systemic inflammation in aneurysmal subarachnoid hemorrhage (aSAH) and its impact on post-aSAH complications
(2018-05-23)Aneurysmal subarachnoid hemorrhage (aSAH) is a dreadful disease with overwhelmingly high mortality and morbidity, although it accounts for only 5% of all strokes. Around half of the affectees are destined to death and it ... -
Investigation of the in vivo Lysosomal Proteome Changes in Different Starvation Periods
(2021-04-09)(noch nicht zugänglich / not yet accessible) -
Investigation of the endocannabinoid system using in vivo and in vitro models
(2013-07-31)The endocannabinoid system (ECS) is a retrograde signaling system that plays an important, pro-homeostatic role in the central nervous system (CNS) by adjusting synaptic communication. The system comprises a set of presynaptic ... -
Investigation of the Nonlinear Optical Properties of Metamaterials by Second Harmonic Generation
(2013-11-27)Metamaterials have attracted tremendous attention in the past decade because they allow researchers to engineer new optical properties by designing a new optical material. In particular, metamaterials are regarded ... -
Investigation of the procoagulant role of labile heme under hemolytic conditions
(2021-07-19)Severe intravascular hemolysis leads to the excessive release of labile heme into the vascular compartment, thereby overwhelming the heme-binding capacity of the protective heme- scavenging system. As a consequence, labile ... -
Investigation of the role of microRNAs in Spinocerebellar Ataxia type 3
(2015-10-30)Spinocerebellar Ataxia Type 3 (SCA3) is an inherited, neurodegenerative disorder belonging to the group of polyglutamine repeat disorders. It is caused by CAG repeat expansions in the ATXN3 gene leading to expanded ... -
Investigation of the symbiosis between filarial nematodes and their Wolbachia bacteria: analysing genes that are differentially expressed after loss of Wolbachia
(2012-11-19)Filarial infections, caused by Brugia malayi, Wuchereria bancrofti and Onchocerca volvulus are a worldwide health problem in developing countries, causing elephantiasis or dermatitis and blindness. 1.3 ... -
Investigation of two different aspects of stem cell biology: The role of Stat3 signaling and innate immunity in human pluripotent stem cells
(2015-01-08)Human pluripotent stem cells (hPSCs) hold great promises as a model for development as well as a source for cells in regenerative medicine. Although hPSC research came into focus in the last decade, many aspects of the ... -
Investigation on the diversity and antimicrobial potential of marine predatory bacteria enabled elucidation of the thio-peptide kocurin and aminophenylpyrrole-derived alkaloids biosynthesis
(2019-07-17)Bacteria are a remarkable source of bioactive compounds, of which many served as lead compounds for the development of medicinal drugs currently used for diverse applications in clinic. Despite the immense bacterial ... -
Investigations into interferon response of novel bat cell cultures upon alphavirus infection
(2013-06-13)Bats have been identified as reservoir for human pathogenic zoonotic viruses like Rabies, Marburg or Henipaviruses. The fact that bats carry viruses without showing clinical symptoms, raised the question if these flying ... -
Investigations into side chain assembly and attachment during biosynthesis of the G protein inhibitor FR900359
(2021-06-07)The natural product FR900359 (FR) selectively inhibits Gaq proteins and thus intracellular signalling of many G protein-coupled receptors. This unique mechanism of action makes FR an indispensable pharmacological tool to ... -
Investigations into the DNP characteristics of electron and proton irradiated polyethylene and polypropylene
(2018-03-06)To achieve a significant enhancement of the nuclear polarisation of solid state target materials one must use the method of dynamic nuclear polarisation. This necessitates unpaired electrons, that can be created as ... -
Investigations of Combined Strategies to reverse P-glycoprotein- and BCRP-mediated Multidrug Resistance in Human Ovarian Cancer Cells and Xenograft Tumors
(2006)Purpose: The ATP-binding cassette (ABC) transporters P-glycoprotein (Pgp) and BCRP are implicated in the multidrug resistance (MDR) of many tumors. Pgp-mediated MDR can be functionally inhibited using small molecule ... -
Investigations of D-glycero-D-ido-octulose (D-g-D-i-oct) metabolism and transketolases in the resurrection plant Craterostigma plantagineum
(2016-02-02)Eight-carbon monosaccharides (C8H16O8) occur naturally in a number of higher plants (e.g. avocado and sedum species), but they did not get much attention in research compared to common ... -
Investigations of Intraday Variable Blazar Cores and the Connected Interstellar Medium
(2006)The work presented here is an attempt to shed further light upon the phenomenon of short-term radio variations (Intraday Variability, IDV) often observed in compact blazar cores. Three different new observational approaches ... -
Investigations on 1,2-oxaphosphetane complexes
(2017-11-27)In this thesis, first derivatives of previously unknown 1,2-oxaphosphetane complexes were synthesized, either by reaction of Li/Cl phosphinidenoid complexes with epoxides or by formal insertion into the OH bond of 2-iodoethanol ... -
Investigations on the early biosynthetic steps of griseorhodin A
(2012-05-03)Presented here are the results concerning the early biosynthesis of the telomerase inhibitor griseorhodin A.
The griseorhodin biosynthetic gene cluster encodes components of a type II polyketide synthase (PKS). The ...
