E-Dissertationen: Auflistung E-Dissertationen nach Titel
Anzeige der Dokumente 1710-1729 von 4070
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Identification of components and substrates of Snf1-related kinase 1 (SnRK1) complexes in Arabidopsis thaliana
(2019-04-04)Similarly to yeast Sucrose nonfermenting 1 (Snf1) and animal AMP-activated protein kinases (AMPKs), plant Snf1-related (SnRK1) kinases play a central role in the regulation of cellular energy homeostasis and responses to ... -
Identification of genetic factors involved in the regulation of stress
(2012-08-29)In this QTL mapping study, several genetic regions were linked to anxiety- and depression-related behavior in the mouse. Furthermore, some previously identified QTL linked to these behavioral traits were verified in the ... -
Identification of Genetic Risk Variants for the Development of Gastric Adenocarcinoma
(2023-03-07)Gastric cancer (GC) is a clinically heterogeneous and one of the most common malignant tumour entities affecting the human gastrointestinal tract with a multifactorial aetiology. Beside environmental risk factors, also ... -
Identification of Genomic Alterations in Castration Resistant Prostate Cancer using Next Generation Sequencing
(2014-01-03)Castration resistant prostate cancer (CRPC) is the most aggressive form of prostate cancer (PCa). For the development of novel therapeutic targets for CRPC, it is key to decipher the molecular alterations underlying this ... -
Identification of hadronic τ decays using the τ lepton flight path and reconstruction and identification of jets with a low transverse energy at intermediate luminosities with an application to the search for the Higgs boson in vector boson fusion with the ATLAS experiment at the LHC
(2010-07-01)Three studies of different components of the object reconstruction with the ATLAS experiment using simulated data are presented. In each study, a method for the improvement of the reconstruction is developed and the ... -
Identification of Intracellular Protein Binding Partners of Cisplatin and Their Role in Acquired and Intrinsic Resistance
(2021-03-18)Cisplatin is a widely used drug in treatment of various solid tumors, amongst others ovarian cancer. However, whereas acquired resistance significantly limits therapy success, some tumors such as colorectal cancer are ... -
Identification of low-valent iron-porphyrins: Electronic structure and reactivity towards CO2 reduction
(2022-01-25)The need to close the carbon cycle becomes urgent as concentration of CO2 in the earth atmosphere increases exponentially. Electrochemically-mediated conversion of CO2 into biofuels is a possible ... -
Identification of new molecular targets and antibiotics as novel strategies against filarial infections: Characterization of lipid II biosynthesis in Wolbachia endobacteria
(2019-06-05)Wolbachia are obligate intracellular bacteria found in many arthropods and some filarial nematodes that are pathogenic in humans. The Wolbachia genomes are highly reduced, but encode proteins required for ... -
Identification of Novel Causative Genes for Colorectal Adenomatous Polyposis
(2015-02-26)In up to 50% of families with clinically verified adenomatous polyposis no germline mutations in the established genes APC and MUTYH can be identified during routine diagnostics although the presence of high numbers of ... -
Identification of novel cytosolic binding partners of the neural cell adhesion molecule NCAM and functional analysis of these interactions
(2014-12-04)The neural cell adhesion molecule (NCAM) plays an important role during brain development and in adult brain. NCAM functions through interactions with several proteins leading to intracellular signal transduction pathways ... -
Identification of novel TAM receptor interacting proteins: Screening for novel ligands
(2019-02-07)The TAM receptors TYRO3, AXL, and MER are well characterized for their roles in cell proliferation and survival, phagocytosis, and inhibition of inflammation. The complexities of these TAM receptor responses imply a level ... -
Identification of Pharmacogenomic and Functional Biomarkers for Antidepressant Treatment Outcome in Patients-Derived Lymphoblastoid Cell Lines
(2023-03-29)Major depression is the most prevalent mental disorder worldwide. Pharmacological management of the disease is considered a cornerstone in treatment guidelines adopted by many industrialized countries. However, response ... -
Identification of Potential Biomarkers for Depressive Disorders
(2017-09-29)The understanding of the individual variability of depressive disorders is in urgent need of improvement which could be accelerated by identification of biomarkers for the diagnosis and treatment individualization of ... -
Identification of protective immune responses and the immunomodulatory capacity of Litomosoides sigmodontis
(2016-11-29)Using the mouse model Litomosoides sigmodontis, research focusing on the protective immune responses within the host as well as the immunomodulatory capabilities of filarial infections is possible. The immunomodulatory ... -
Identification of Quantitative Trait Loci in Alcoholism
(2009-07-20)The aim of the present study was the identification of chromosomal loci that contribute to the development and manifestation of behaviours related alcohol drinking and alcohol withdrawal. For this purpose, a serial behavioural ... -
Identification, Distribution, and Function of Gastroliths in Dinosaurs and Extant Birds with Emphasis on Ostriches (Struthio camelus)
(2004)Gastroliths (stomach stones) are known from many extinct and extant vertebrate clades and are potentially useful for paleobiological interpretations. This dissertation investigates the identification, function, distribution, ... -
Identification, optimization and characterization of pharmacological tools for the cannabinoidactivated orphan G protein-coupled receptor GPR18 and related receptors
(2017-12-21)Cannabinoid receptors comprise two classical subtypes, CB1 and CB2, which belong to the large family of G protein-coupled receptors (GPCRs). They are the major targets of cannabinoids such as ... -
Identifikation epigenetisch regulierter Gene in Gliomen
(2005)In der vorliegenden Arbeit wurde die Beteiligung de novo methylierter Gene auf die Entstehung von Gliomen untersucht. Gliome sind die häufigsten intrakranialen Neoplasien beim Menschen. Mit einer Inzidenz von 7 Fällen pro ... -
Identifikation immunstimulatorischer Nukleinsäureliganden zur Stimulation von Rezeptoren der angeborenen Immunantwort
(2009-05-05)Eine zentrale Rolle der angeborenen Immunität ist die unverzügliche Eingrenzung und Abwehr von Virusinfektionen, bevor Mechanismen der angeborenen Immunität induziert werden, die spezifisch dem Virus entgegenwirken. ...
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Identifikation und Charakterisierung differenziell exprimierter Gene in einer Mausmutanten mit prolongierter Engrailed-2 Expression mithilfe der Array-Technologie
(2007)Die Überexpression von Engrailed-2 in den Purkinjezellen des Kleinhirns der L7En-2 Maus führt zu einem cerebellären Phänotyp, der bisher auf morphologischer Ebene gut untersucht ist, dessen genetischer, physiologischer und ...
