E-Dissertationen: Browsing E-Dissertationen by Title
Now showing items 1786-1805 of 4057
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The implication of microglial sialic acid-binding immunoglobulin-like lectin-E (Siglec-E) in neuroinflammation
Claude, Janine (2014-03-07)Microglia are the resident immune cells of the central nervous system (CNS). They display a whole set of recognition receptors on their cell surface to sense intact or lesioned cells in the CNS. A subfamily of these receptors ... -
Implication of the TREM2/DAP12 Complex in Microglial-mediated Tissue Homeostasis under Healthy and Pathological Conditions
Bodea, Liviu-Gabriel (2014-03-26)Microglial activation was previously associated with neurodegenerative diseases such as Parkinson’s disease (PD) or Alzheimer’s disease (AD). The prototype of primary microglia neurodegenerative disorder is represented by ... -
The importance of endogenous cannabinoids in stress-related disorders and depression
Jenniches, Imke (2017-02-03)The endogenous cannabinoid system (ECS) is a unique neuromodulatory system, essentially involved in a variety of physiological processes. It consists of the two major endogenous cannabinoids (eCBs), anandamide and 2-AG, ... -
The importance of endogenous opioids in feeding behavior
Ghule, Aishwarya (2018-03-14)Endogenous opioids are involved in a broadly distributed neural network regulating eating behavior. Opioid transmission has long been implicated in controlling hedonic and homeostatic feeding as well as regulating body ... -
Improved Approximation Algorithms for Weighted k-Set Packing
Neuwohner, Meike (2024-01-16)We study the weighted k-Set Packing problem, which is defined as follows: The input consists of a finite collection S of non-empty sets, each of cardinality at most k, as well as a positive weight for each of the sets. The ... -
Improved Cardinality Bounds for Rectangle Packing Representations
Silvanus, Jannik (2019-05-29)Axis-aligned rectangle packings can be characterized by the set of spatial relations that hold for pairs of rectangles (west, south, east, north). A representation of a packing consists of one satisfied spatial relation ... -
Improved techniques for pulsar data analysis
Voraganti Padmanabh, Prajwal (2021-09-29)Pulsars are rapidly rotating, strongly magnetised neutron stars with spin periods ranging from few milliseconds to tens of seconds. They emit beams of electromagnetic radiation that are predominantly detected as periodic ... -
Improvement of hail detection and nowcasting by synergistic combination of information from polarimetric radar, model predictions, and in-situ observations
Schmidt, Mari Luna (2020-10-21)Large hail can pose a major threat to people, infrastructure, and property. While polarimetric radar observations enable us to reliably detect hail, discrimination of hail size and strategies to nowcast and predict hail ... -
Improvements and application of the STatistical Analogue Resampling Scheme STARS
Lutz, Julia (2017-07-03)Basically, there are two approaches to downscale climate simulations from global climate models to a regional scale: dynamical and statistical downscaling. This thesis focuses on a statistical method – the Statistical ... -
Improving solubility and supersaturation of poorly soluble drugs using solid dispersions based on natural polymers and mixtures thereof
Kapote, Dnyaneshwar Nandkumar (2021-05-19)The poor solubility of existing drug substances and new chemical entities is a problem in modern pharmaceutical development. There are various strategies to overcome the solubility limited bioavailability of poorly soluble ... -
Improving stationary and mobile cosmic ray neutron soil moisture measurements: Assessment of the cosmic ray neutron uncertainty and the potential of the thermal neutron signal
Jakobi, Jannis Christoph (2022-10-25)Cosmic ray neutron sensors (CRNS) measure the epithermal neutron intensity (~0.5 eV – 100 keV) above the ground, which inversely depends on the amount of hydrogen in 130 to 240 m radius and soil depths of 15 to 83 cm. In ... -
Improving the simulation of small-scale variability in radiation and land-surface parameterizations in a mesoscale numerical weather prediction model
Schomburg, Annika (2011-10-17)For the simulation of subgrid-scale physical processes in mesoscale numerical weather prediction models various kinds of spatial and temporal sampling or averaging methods are employed to decrease their computational burden. ... -
Improving Usability in Procedural Modeling
Ganster, Björn (2013-02-22)This work presents new approaches and algorithms for procedural modeling geared towards user convenience and improving usability, in order to increase artists’ productivity. Procedural models create geometry for 3D models ... -
In search for novel agents in therapy of Plasmodium falciparum
Sarite, Salem Ramadan (2008)Malaria is an infectious disease transmitted by the bite of the female Anopheles mosquito. It’s the third most infectious cause of mortality, is prolific in more than 40% of the world’s population and causes ...
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In Silico Understanding of the Hydrogen Bond Network in Organic Solvent Mixtures
Marchelli, Gwydyon (2022-05-20)In the framework of green chemistry, it is fundamental to further investigate the intermolecular interactions that define the dynamics and structure of liquids and their mixtures. Among those, the hydrogen bond in particular ... -
In silico, in vitro und in vivo Charakterisierung der Hemmung ausgewählter Fremdstoff-metabolisierender Enzyme des Menschen durch Voriconazol
Junge, Lisa (2016-04-12)Zur Präzisierung des inhibitorischen Potentials des etablierten Antimykotikums Voriconazol auf ausgewählte, den Midazolam-Metabolismus betreffende Enzyme wurden Inhibitionsstudien in vitro und in vivo durchgeführt, um ... -
In situ STM-Untersuchungen ultradünner Münzmetallchalkogenidfilme auf Au(1 0 0) und Au(1 1 1)-Elektrodenoberflächen
Schlaup, Christian Georg (2011-07-04)Die Arbeit beschäftigt sich mit den Wechselwirkungen zwischen einkristallinen Elektrodenoberflächen und Hydroxid- bzw. Hydrogensulfid-Ionen haltigen Elektrolyten. Dabei stehen neben Phasen aus spezifisch adsorbierten Anionen ... -
In vivo Relevant Drug Product Evaluation by Using the Biphasic Dissolution Assay (BiPHa+)
Denninger, Alexander Peter (2022-06-13)An increasing number of new chemical entities struggled with a very poor solubility in aqueous media. Solubility or the ability to dissolve in intestinal media is obligatory for oral bioavailability. Dealing with this ... -
In-situ characterization of self-assembled organic layers at anion modified metal/electrolyte interfaces
Phan, Thanh Hai (2013-08-22)The self-assembly of molecular layers has become an important strategy in modern design of functional materials. The sheer unlimited “design” of the properties of the organic molecules and their well controlled deposition ... -
Inclusive and differential cross-section measurements of tW single top-quark production at √s = 13 TeV with the ATLAS detector
Zhang, Rui (2019-06-27)This thesis presents the inclusive cross-section measurement and so far the first differential cross-section measurement for the associated production of a top quark and a W boson, known as the tW-channel, at 13TeV. The ...