E-Dissertationen: Browsing E-Dissertationen by Author "Lamprecht, Alf"
Now showing items 21-40 of 42
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Innovative analytical tools in the biopharmaceutical development: Applying SPR/Biacore, calorimetry and light scattering methods to the study of interactions between anticancer antibodies and the EGFR
Alvarenga, Maria Leonor Mendes Godinho de (2010-12-08)Targeting of the epidermal growth factor receptor (EGFR) has become an established antitumor strategy with anti-EGFR antibodies approved for clinical use or in late stages of development. Postulation of antibody effector ... -
Innovative Pharmaceutical Stabilization and Formulation Techniques for Protein Drugs
Dauer, Katharina (2023-12-18)Solid protein formulations for peroral, nasal or parenteral administration would significantly improve the therapeutic use, compliance, and stability of protein-based drugs. The aim of this work was to develop, apply, and ... -
Intraarticular pharmacokinetics of biologics and drug-delivery strategies to extend transsynovial permeation
Siefen, Tobias (2023-02-21)(noch nicht zugänglich / not yet accessible) -
Investigation of new mechanisms causing hemophilia A
Pezeshkpoor, Behnaz (2014-02-05)The main aim of this work was identification of novel molecular mechanisms causing hemophilia A, with a special focus on patients without detectable mutation. In most of hemophilia A patients, mutations could be identified ... -
Investigation of systemic inflammation in aneurysmal subarachnoid hemorrhage (aSAH) and its impact on post-aSAH complications
Chaudhry, Shafqat Rasul (2018-05-23)Aneurysmal subarachnoid hemorrhage (aSAH) is a dreadful disease with overwhelmingly high mortality and morbidity, although it accounts for only 5% of all strokes. Around half of the affectees are destined to death and it ... -
Lipid-basierte Transfektionssysteme für die posttranskriptionelle Expressionshemmung von endothelialem VCAM-1 als potentiell antiinflammatorischer Therapieansatz
Hartung, Astrid (2011-08-04)Bei der Entstehung von Entzündungen ist das vaskuläre Endothel von zentraler Bedeutung: Stimuliert durch Entzündungsmediatoren exprimieren Endothelzellen eine Reihe proinflammatorischer Adhäsionsrezeptoren, die eine Anhaftung ... -
Model-based formulation of amorphous solid dispersions made by hot-melt extrusion
Bochmann, Esther Sophia (2019-08-21)Regarding hot-melt extrusion in early pharmaceutical formulation and process development, techniques and procedures are needed to simplify the application of hot-melt extrusion (HME) and to decrease the effort in terms of ... -
Modelle zur Simulation des Abfüllprozesses biologisch-pharmazeutischer Arzneimittel
Denkinger, Sandra Nicole (2010-07-29)Bei der Abfüllung von Proteinlösungen kann eine Degradation der Moleküle durch Kontakt zu verschiedenen Materialien und durch Scherkräfte verursacht werden. Es wurden verschiedene Modelle verwendet, um den Einfluss von ... -
Nanocarrier system for overcoming multidrug resistance in cancer
Singh, Manu Smriti (2015-02-04)Of all the cases, majority of cancer patients respond to therapeutic interventions transiently or incompletely. These multidrug resistant (MDR) cancer cases are either resistant to chemotherapy or acquire resistance during ... -
Notwendigkeit klinischer Prüfungen bei technischen Änderungen an der Applikationseinheit von Inhalationsprodukten
Pelzer, Kris (2013-02-15)Inhalationsprodukte besitzen eine Sonderstellung unter den Arzneimitteln, weil ihr therapeutisches Profil in entscheidendem Maß von einem Bestandteil des Behältnisverschlusssystems, der Applikationseinheit, beeinflusst ... -
Particle engineered inhalable dry powders of rifampicin
Berkenfeld, Kai Wilfried August (2019-12-12)Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Main site of infection are the lungs, but infection of other organs can occur in later stages. First line therapy includes antibiotic therapy ... -
Process models for the continuous manufacturing of tablets via direct compression
Kreiser, Marius Johannes (2022-12-08)The modularity of the continuous manufacturing line PCMM is accompanied by a complexity of parameter connections and process dependencies. To develop a holistic understanding of the continuous process, this work examined ... -
Sphärische Lyophilisate zur pulmonalen Proteinapplikation
Wanning, Stefan Alexander (2019-07-12)Die pharmazeutische Sprüht-Gefrier-Trocknung (Spray-Freeze-Drying) umfasst ein heterogenes Feld von Technologien mit primären Anwendungen in den Bereichen Löslichkeitsverbesserung, pulmonale und nadelfreie intra-dermale ... -
Supersaturation and solubilization to enhance the oral bioavailability of poorly soluble drug molecules: A mechanistic understanding of their potential and limitations
López Mármol, Álvaro (2021-07-28)The stabilization of the supersaturated state in solution was in the last few decades identified as a suitable strategy to enhance the oral bioavailability of poorly soluble drug molecules. From this point of view, drug ... -
Targeted transport of active pharmaceutical ingredients into adipose tissue
Niu, Zheming (2023-02-21)(noch nicht zugänglich / not yet accessible) -
Tröpfchenlyophilisate für die Augenheilkunde
Gruner, Katja (2011-05-24)Im Rahmen der vorliegenden Arbeit wurden Tröpfchenlyophilisate zur Anwendung am Auge hergestellt und charakterisiert. Unter Tröpfchenlyophilisaten werden kleinteilige gefriergetrocknete Produkte zusammengefasst, die aus ... -
Twin-screw Melt Granulation as alternative Granulation Strategy
Steffens, Kristina Elena (2021-07-28)Melt granulation is an interesting alternative technique to produce both, immediate and controlled-release final products using twin-screw extruders. The aim of this current work was to gain a deeper understanding of the ... -
Untersuchungen zu Extractables aus Gummistopfen sowie deren Wechselwirkungen mit Modellproteinen
Richter, Carolin (2022-09-21)Parenteralia, also sterile Arzneimittelformulierungen, die zur Injektion, Infusion oder Implantation bestimmt sind, werden hauptsächlich in flüssiger oder lyophilisierter Form in Glasbehältnissen angeboten, die mit einem ... -
Untersuchungen zum Metabolismus und Nachweisfenster von γ-Hydroxybuttersäure in biologischem Material
Mehling, Lena-Maria Katharina (2018-03-19)In dieser Arbeit wurden interdisziplinäre Untersuchungen durchgeführt, um die Nachweisbarkeitsdauer nach einer Gamma-Hydroxybuttersäure-(GHB)-Gabe in biologischen Matrices zu verlängern. Es sollten biologische Marker ... -
Vacuum drum drying: a novel technology for enabling formulation principles in the development of oral solid dosage forms
Schönfeld, Barbara Veronika (2022-11-21)The present work demonstrates the applicability of vacuum drum drying (VDD) as novel technology in the development of solid, oral dosage forms for two enabling formulation principles: a) manufacture of amorphous solid ...