E-Dissertationen: Auflistung E-Dissertationen nach Titel
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Role of interleukin-6 during infection with the filarial nematode Litomosoides sigmodontis
Muhsin (2013-12-04)Lymphatic filariasis is a neglected tropical disease that is caused by parasitic helminths and affects 120 million people worldwide, while 1.3 billion people live in endemic areas. Three species of tissue dwelling nematodes ... -
The role of linear energy transfer in modulating radiationinduced NF-κB activation and its down-stream target genes
Chishti, Arif Ali (2014-07-23)To enable long-term human spaceflight, the cellular radiation response to heavy ions with a high linear energy transfer (LET) needs to be better understood for developing appropriate countermeasures to mitigate acute effects ... -
Role of long-range CA3 connectivity in linking spatial and aversive information
Nikbakht, Negar (2022-04-12)The CA3 region of the hippocampus is an auto-associative network that is thought to enable rapid associations between spatial locations and non-spatial information. As such, it is important for retention and retrieval of ... -
The role of mass movements for slope evolution: conceptual approaches and model applications in the Bonn area
Schmidt, Jochen (2001)Understanding slope processes and slope systems in different timescales is focused by a range of approaches from different disciplines. This work is based on a multi-disciplinary research approach within the project SFB350 ... -
Role of membrane lipids in regulation of Alzheimer’s disease associated proteins and vice-a-versa
Tamboli, Irfan Yunus (2008)Alzheimer’s disease (AD) is associated with extracellular deposits of the amyloid β- peptide (Aβ) and intraneuronal aggregates of hyperphosphorylated tau protein in the brain. Aβ is generated by sequential proteolytic ... -
The Role of microRNAs in the Regulation of Human UDP-glucuronosyltransferases (UGTs)
Paulusch, Stefan (2021-06-14)The liver is involved in endo- and xenobiotic metabolism due to the expression of drug-metabolizing UDP-glucuronosyltransferases (UGTs). By UGT-mediated elimination of hazardous compounds and other reactive metabolites, ... -
The role of MyD88-dependent signaling pathways in skin mast cells in UVB-induced skin diseases
Majlesain, Yasmin (2022-03-04)Excessive UV irradiation is a major risk factor for health. While chronic long-term UV exposure induces skin aging and suppression of the immune system, acute UV exposure leads to skin inflammation, also known as sunburn. ... -
The Role of NMDA Receptor Co-Agonists in Dendritic Integration
Bohmbach, Kirsten (2021-03-26)The integration of synaptic inputs is the fundamental function of neurons. This integration does not only take place at the soma, but also dendrites can actively shape the input-output computations of a neuronal network. ... -
Role of Pathogenic Mediators in murine Arthritis and Levels of Serum Soluble CD21 and CD23 in autoimmune patients
Singh, Anjana (2009-03-23)Importance of the nervous system in immune regulation is clearly suggested by innervations of lymphoid tissues by sympathetic nerve fibers. We determined the role of sympathetic, parasympathetic and peripheral nervous ... -
The Role of Phytol Degradation in Chlorophyll and Tocopherol (Vitamin E) Metabolism
Yang, Wentao (2021-10-14)The phytol degradation in the model plant Arabidopsis thaliana was studied. Phytol is the hydrophobic side of chlorophyll and is considered to be most abundant isoprenoid molecule in the biosphere. But the degradation of ... -
The role of PPARγ in myeloid cells in experimental autoimmune encephalomyelitis
Floßdorf, Juliane (2013-05-06)Multiple sclerosis (MS) is a common chronic inflammatory demyelinating disease of the central nervous system (CNS) affecting more than 1 million people worldwide. It mainly affects young adults and has a great impact on ... -
Role of presenilins in autophagy and growth factor signaling
Roeser, Sebastian Philip (2021-02-08)Alzheimer's disease is the most common neurodegenerative disease and affects millions of people worldwide. To date, no efficient therapies are known for a cure. As people suffering from diabetes mellitus type 2 have an ... -
The role of soil heterogeneity on field scale evapotranspiration: 3D integrative modelling and upscaling of root water uptake
Huber, Katrin (2015-09-24)Background and Motivation: Hydrological models mainly rely on empirical functions to describe root water uptake. However, in case of water limitation due to either scarce or heterogeneously distributed soil water, ... -
The role of soluble guanylate cyclase in metabolism
Naumann, Jennifer (2018-10-31)Obesity is a worldwide health problem characterized by a chronic positive energy balance. The excess energy is stored primarily as lipids (TGs) in white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) utilizes ... -
The role of sphingosine-1-phosphate lyase (SPL) in the brain: Studies in brain-targeted SPL-deficient mice
Mitroi, Daniel Nicolae (2017-05-15)The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. It was shown previously that neuronal S1P accumulation is toxic leading to ER-stress ... -
The role of Sphingosine-1-phosphate receptors in adipocytes and adipose tissues
Prünte, Laura (2021-01-19)Obesity is a worldwide health issue with increasing numbers of patients every year. Moreover, the prevalence of obesity gives rise to related cardiovascular diseases and various other comorbidities influencing quality of ... -
The role of T helper 17 cells in the Pathogenesis of Human Onchocerciasis
Katawa, Gnatoulma (2015-03-31)Onchocerciasis, also known as river blindness, is a tropical disease causing health and socioeconomic problems in endemic communities, especially sub-Saharan Africa. The disease is elicited by a filarial parasite called ... -
Role of the VAsodilator-Stimulated Phosphoprotein (VASP) in brown fat cell differentiation and function
Jennißen, Katja (2012-05-23)Obesity and associated metabolic disorders result from an imbalance between energy intake and expenditure. In contrast to white fat, which is the major site of energy storage in the body, brown adipose tissue (BAT) is ... -
The role of the AhR signaling pathway in regulation of gut-associated immune cells
Schanz, Jan Oliver (2018-07-16)The aryl hydrocarbon receptor (AhR) is an important sensor for environmental polyaromatic chemicals and plays an essential role in immune regulatory processes, including maintenance of intestinal barrier integrity. AhR ... -
The role of the cannabinoid receptor 2 in alcohol-induced neuroinflammation and alcohol addiction
Pradier, Bruno (2015-02-11)Chronic alcohol abuse leads to severe brain damage, which has been associated with alcohol-induced neuroinflammation. Recently, the cannabinoid receptor 2 (CB2), which is predominantly expressed on immune cells, ...