E-Dissertationen: Auflistung E-Dissertationen nach Titel
Anzeige der Dokumente 3143-3162 von 4069
-
The role of soluble guanylate cyclase in metabolism
(2018-10-31)Obesity is a worldwide health problem characterized by a chronic positive energy balance. The excess energy is stored primarily as lipids (TGs) in white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) utilizes ... -
The role of sphingosine-1-phosphate lyase (SPL) in the brain: Studies in brain-targeted SPL-deficient mice
(2017-05-15)The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. It was shown previously that neuronal S1P accumulation is toxic leading to ER-stress ... -
The role of Sphingosine-1-phosphate receptors in adipocytes and adipose tissues
(2021-01-19)Obesity is a worldwide health issue with increasing numbers of patients every year. Moreover, the prevalence of obesity gives rise to related cardiovascular diseases and various other comorbidities influencing quality of ... -
The role of T helper 17 cells in the Pathogenesis of Human Onchocerciasis
(2015-03-31)Onchocerciasis, also known as river blindness, is a tropical disease causing health and socioeconomic problems in endemic communities, especially sub-Saharan Africa. The disease is elicited by a filarial parasite called ... -
Role of the VAsodilator-Stimulated Phosphoprotein (VASP) in brown fat cell differentiation and function
(2012-05-23)Obesity and associated metabolic disorders result from an imbalance between energy intake and expenditure. In contrast to white fat, which is the major site of energy storage in the body, brown adipose tissue (BAT) is ... -
The role of the AhR signaling pathway in regulation of gut-associated immune cells
(2018-07-16)The aryl hydrocarbon receptor (AhR) is an important sensor for environmental polyaromatic chemicals and plays an essential role in immune regulatory processes, including maintenance of intestinal barrier integrity. AhR ... -
The role of the cannabinoid receptor 2 in alcohol-induced neuroinflammation and alcohol addiction
(2015-02-11)Chronic alcohol abuse leads to severe brain damage, which has been associated with alcohol-induced neuroinflammation. Recently, the cannabinoid receptor 2 (CB2), which is predominantly expressed on immune cells, ... -
Role of the cannabinoid receptor 2 in the development of surgical neuropathic pain
(2018-12-12)When normal nociceptive pain becomes chronic, it loses its protective function and causes a general pain hypersensitivity. Neuropathic pain is one type of chronic pain, which is caused by various diseases or physical injury ... -
The role of the cannabinoid receptor 2 in the modulation of neuropathic pain
(2013-11-19)Neuropathic pain is a debilitating, chronic pain condition associated with inflammation or injury of peripheral and central nerves (Milligan and Watkins, 2009). The existing pharmacotherapies either lead to an inadequate ... -
The role of the CC chemokine CCL17 in a mouse model of Alzheimer’s disease
(2013-07-25)In Alzheimer's disease (AD), inflammatory processes are critically involved by cells releasing neurotoxic or neurotrophic factors influencing survival of neurons and synapses, and thereby cognitive behavior. Several ... -
The role of the chemokine receptor CXCR3 in mouse models for IL-12-driven CNS-inflammation and Morbus Alzheimer-like neurodegeneration
(2013-01-31)The chemokine receptor CXCR3 and its corresponding ligands CXCL9, CXCL10 and CXCL11 are well known to be involved in the trafficking and migration of activated CD4+ Th1 T cells, CD8+ T cells and NK ... -
The role of the endocannabinoid receptor CB2 in a mouse model of Alzheimer's disease
(2018-09-26)Over the past years, an important role of the cannabinoid receptor 2 (CB2) has been implicated in several neurological and immunological conditions, such as experimental autoimmune encephalitis, stroke, memory, neuropathic ... -
The role of the endocannabinoid system in stress-related disorders and neuroimmune communication
(2020-05-04)In the last decades, increasing evidence suggests that inflammatory processes play an important role in the development of psychiatric disorders, such as anxiety and depression. Psychosocial stress – one of the main ... -
The role of the Hippo pathway in etiology and progression of pancreato-biliary tumors and clear cell renal cell carcinoma
(2016-01-21)In the quest for the discovery of novel targets for cancer therapy, aberrantly reactivated embryonic signaling pathways have proven to be a rich mine and recent years have seen the introduction of the hedgehog-inhibitor ... -
The role of the miR-17-92 cluster in macrophage driven innate immunity
(2018-12-11)Research into miRNA, discovered in 1993, has exploded and revolutionized our understanding of molecular regulation in biological systems. MicroRNAs are now a well established as a regu- latory mechanism of many pathways ... -
Role of the proton channel HVCN1 in the regulation of neutrophil activation
(2023-06-22)(noch nicht zugänglich / not yet accessible) -
Role of the Receptor for Advanced Glycation End-products (RAGE) in the Immune Sensing of Nucleic Acids
(2016-09-06)Nucleic acid recognition is an important mechanism that enables the innate immune system to detect both microbial infection and tissue damage. To minimize the recognition of self-derived nucleic acids, all nucleic acid ... -
The role of the salvage pathway of phytol, geranylgeraniol, and farnesol phosphorylation in Arabidopsis thaliana
(2021-03-09)The isoprenoid alcohol phytol can be phosphorylated in Arabidopsis to phytyl-phosphate (phytyl-P) by the phytol kinase (VTE5) and further to phytyl-diphosphate (phytyl-PP) by the phytyl phosphate kinase (VTE6). Phytyl-PP ... -
The role of the stemness factor Nanog in cell cycle regulation
(2011-01-12)Pluripotency of embryonic stem (ES) cells is maintained through various extrinsic and intrinsic influences. In the center of intrinsic stemness signaling, a triad of transcription factors, namely Nanog, Oct3/4 and Sox2, ... -
The role of the transcription factor BCL11A in midbrain dopaminergic neurons
(2022-03-11)Midbrain dopaminergic (mDA) neurons are located in three midbrain nuclei, the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field (RRF). mDA neurons are diverse in their developmental origin, their ...
