eDissertationen: Browsing eDissertationen by Title
Now showing items 370-389 of 3353
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Cellular and synaptic correlates of learning and memory and their impairment in a mouse model of Alzheimer's disease
(2017-11-28)Alzheimer's disease (AD) is characterized by synaptic dysfunction and progressive memory loss. The hippocampus is indispensable for memory processes and early affected by disease-associated pathology. It is still debated ... -
Cellular biomechanics in 2D and 3D epithelial model tissues: from keratin intermediate filaments to breast gland in vitro reconstructed basement membranes
(2017-01-24)The mechanical organization of biological tissue is crucial to the load-transmitting capacity of our bodies, and follows a hierarchical architecture that macroscopically results in organ’s formation and function. At the ...
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Cellular Influx and Cytotoxicity of Oxaliplatin Analogues
(2010-10-08)This thesis describes the first systematic investigation of the relationship between lipophilicity and reactivity on the one hand and cellular accumulation and cytotoxic activity on the other hand of a new class of oxaliplatin ... -
Centralisers of polynomially growing automorphisms of free groups
(2013-07-31)The main theorem of this thesis asserts that many centralisers in the automorphism groups Aut(F_n) and Out(F_n) of the free group F_n satisfy finiteness property VF, i.e. these centralisers have a finite index subgroup ... -
Ceramide Synthase in Transcriptional Regulation and Lipid Sensing
(2019-05-20)Ceramide synthases (CerS) are highly conserved transmembrane proteins necessary for sphingolipid biosynthesis. CerSs carry a TLC (Tram-Lag1-CLN8) domain, containing a conserved Lag1p motif required for ceramide synthesis. ... -
Chalkogenanthrene und Übergangsmetallhalogenide – Komplexbildung und Redox-Reaktionen
(2015-12-01)In der vorliegenden Arbeit wurde das Reaktionsverhalten der Chalkogenanthrene Thianthren (TA), Selenanthren (SeA) und Phenoxathiin (PhA) gegenüber Lewis-sauren Metallhalogeniden der Summenformel MX5 (M = Nb, Ta; ... -
Chalkogenpolykation-Halogenidobismutate: Salzartige Verbindungen mit hoher struktureller Komplexität
(2010-04-14)Im Rahmen der vorliegenden Arbeit wurden Chalkogenpolykation-Halogenidobismutate dargestellt, ihre Struktur durch Röntgenstrahlungsbeugung bestimmt und ihre physikalischen Eigenschaften untersucht. Dabei wurden neue ... -
Challenges of theoretical and numerical structure formation in a ΛCDM universe
(2015-06-22)Systematic surveys of the extra-galactic sky have revealed the existence of large-scale structures in the Universe: the galaxy distribution is organized in a complex network of filaments surrounding underdense regions and ... -
Chancen nachhaltiger Entwicklung altindustrialisierter Regionen in China, untersucht am Beispiel der Region Xuzhou
(2010-12-02)Der Niedergang altindustrialisierter Regionen ist in den Industrieländern seit den 1970er Jahren ein auffälliges Phänomen. In den sog. „Entwicklungsländern“, zu denen sich die V. R. China selbst zählt, gibt es ebenfalls ... -
Changes of inhibitory micronetworks in the epileptic hippocampus and their response to anticonvulsant drugs
(2015-11-12)With around 50 million people worldwide suffering from chronic epilepsy, it is one of the most common neurological disorders. However, despite extensive research in this area, the actual network mechanisms involved in the ... -
Changing Cultural Landscapes around the Jostedalsglacier (West Norway), from Cultural Landscape Management to Cultural Landscape Governance – a Future Path?
(2016-12-22)Study Aim
The present research focuses on the question how to design future cultural landscape management and cultural landscape dynamics. Cultural landscape change, as it takes place in West Norway, gains increased ... -
Changing distribution patterns of selected conifers in the Quaternary of Europe caused by climatic variations
(2005)Extreme climatic variations in the Quaternary of Europe did not only lead to an intense reduction of plant diversity, but also to significant changes in plant distribution. It is the aim of this work to exemplary investigate ... -
Characterisation of a MAPKK kinase from Craterostigma plantagineum: Interaction of VIK kinases and LEA proteins
(2018-02-21)Drought is a key factor for yield loss in agriculture. However, desiccation tolerant plant species evolved various mechanisms to protect vegetative tissues from the hazardous effects of drought. These mechanisms are not ... -
Characterisation of Brainstem Lateral Line Neurons in Goldfish, Carassius auratus: Frequency Selectivity, Spatial Excitation Patterns and Flow Sensitivity
(2010-02-02)In the present study lateral line units in the medial octavolateral nucleus (MON) in the brainstem in goldfish, Carassius auratus, were extracellulary recorded. The aim of the work was to investigate and characterize the ... -
Characterisation of selected Arabidopsis aldehyde dehydrogenase genes: role in plant stress physiology and regulation of gene expression
(2011-03-02)The importance of aldehyde dehydrogenase (ALDH) proteins in plant stress responses was investigated in this study by functionally analysing transgenic Arabidospsis thaliana ALDH knock-out and over-expressing plants. From ... -
Characterisation of the unknown gene and the corresponding protein At3g29075 in Arabidopsis thaliana
(2020-04-01)Phospholipases D (PLDs) are involved in different plant stress responses, exclusively to abiotic stresses like cold, salinity, and drought. The PLD enzymes catalyse the hydrolysis of membrane phospholipids into phosphatidic ... -
Characteristics of Potential Vorticity anomalies associated with mesoscale extremes in the extratropical troposphere
(2016-07-21)Severe convective weather, which has a huge impact on society, is influenced by a large range of scales. However, extremes, by definition rare events, are especially hard to forecast. This study proposes to use Potential ... -
Characterization and application of fusogenic liposomes
(2020-02-03)Conventional drug delivery strategies use the endocytic pathway to introduce biomolecules like proteins, DNA, or antibiotics into living cells. The main disadvantage of endocytic uptake is the quick intercellular degradation ... -
Characterization of Arabidopsis Myotubularins AtMTM1and AtMTM2: from Development to Stress Adaptation
(2014-11-18)Myotubularins belong to a unique subgroup of a large family of dual-specificity serine–threonine phosphatase (DSP) that dephosphorylates serine / threonine as well as tyrosine residues. In Arabidopsis thaliana ... -
Characterization of cellular functions of the deubiquitinating enzyme OTUD4
(2020-08-10)Post-translational modification of proteins with ubiquitin influences myriad of cellular processes by affecting protein stability, degradation, localization and protein-protein interactions. Ubiquitin gets transferred to ...
