E-Dissertationen: Browsing E-Dissertationen by Title
Now showing items 815-834 of 4070
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Development and Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Population Model for Elderly Individuals
Schlender, Jan-Frederik (2019-07-04)Clinical drug development is traditionally focused on young and middle-aged adults. The elderly are often underrepresented in clinical trials, even though persons aged 65 years and older receive the majority of drug ... -
Development and Interpretation of Machine Learning Models for Drug Discovery
Balfer, Jenny (2015-11-19)In drug discovery, domain experts from different fields such as medicinal chemistry, biology, and computer science often collaborate to develop novel pharmaceutical agents. Computational models developed in this process ... -
Development and optimization of analytical methods for identifying and quantifying organic compounds in biological and paleontological specimens
Tahoun, Mariam Gamal Mohamed Elsaid (2023-12-01)Preservation of soft tissues is a rare phenomenon which leads to the formation of fossils that survive for millions of years and are then subject to investigations by paleontologists. Several classes of chemical compounds ... -
Development and Validation of Analytical Methods for Mycotoxins in Food, Medicinal Herbs and Feed
Arranz Hernández, Isabel (2010-01-26)This thesis concerns with the development and the validation of analytical methods for the determination of the mycotoxins aflatoxin B1, zearalenone and patulin, which occur frequently in food and feed. The toxic syndromes ... -
Development of Ortho-Substituted Aromatic (Thio)ureas and Derived Heterocycles as Modulators of P-Glycoprotein and Multidrug Resistance-Associated Protein 1
Häcker, Hans-Georg (2010-03-29)In this work, different series of ortho-substituted aromatic (thio)ureas and derived heterocycles were synthesized for various biological investigations. The studies included the establishment of new synthetic routes ... -
Development of a Benchmark Parameter Scan for Higgs Bosons in the NMSSM Model and a Study of the Sensitivity for H->AA->4τ in Vector Boson Fusion with the ATLAS Detector
Rottländer, Iris (2008)An evaluation of the discovery potential for NMSSM Higgs bosons of the ATLAS experiment at the LHC is presented. For this purpose, seven two-dimensional benchmark planes in the six-dimensional parameter space of the ...
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Development of a fuzzy expert system for detailed land cover mapping in the Dra catchment (Morocco) using high resolution satellite images
Schmidt, Michael (2003)Land cover and the distribution of vegetation are important parameters in models describing the earth system. The work described in this thesis was performed in the framework of the IMPETUS project in order to deliver this ... -
Development of a Laboratory Readout System for DEPFET Pixel Detector Modules and Investigation of Radiation Backgrounds at the SuperKEKB Accelerator
Ahlburg, Patrick (2023-01-23)With the upgrade from the e^+ e^- -collider KEKB to SuperKEKB, a 40-fold increase in instantaneous luminosity is targeted posing new challenges for the Belle II detector. Particularly the innermost detector layers, consisting ... -
Development of a new reconstruction and classification method for Tau leptons and its application in the ATLAS detector at the LHC
Limbach, Christian (2015-05-13)This thesis presents a new method for the reconstruction and classification of hadronically decaying tau leptons in the ATLAS detecor at the LHC. It also presents a possible application of the new methods.
The new ... -
Development of a satellite-based dynamic regional vegetation model for the Drâa catchment
Fritzsche, Pierre (2011-02-07)Analysing and modelling land cover dynamic of the vegetation under a changing hydrological cycle inside the semi-arid area resulting from the global climate change are a difficult task. It is important to be able to ... -
Development of a serial powering scheme and a versatile characterization system for the ATLAS pixel detector upgrade
Filimonov, Viacheslav (2017-08-22)In order to increase the probability of new discoveries the LHC will be upgraded to the HL-LHC. The upgrade of the ATLAS detector is an essential part of this program. The entire ATLAS tracking system will be replaced by ... -
Development of anFPGA-based Data Reduction System for the Belle II DEPFET Pixel Detector
Schnell, Michael (2015-07-14)The innermost two layers of the Belle II detector at the KEKB collider in Tsukuba, Japan will be covered by highly granular DEPFET pixel sensors. The large number of pixels lead to a maximum data rate of 256 Gbps, which ... -
Development of capillary electrophoresis-based assays for nucleoside and nucleotide metabolizing enzymes
Iqbal, Jamshed (2005)The aim of the present work was to develop and optimise capillary electrophoresis-based methods for the assaying of nucleoside and nucleotide metabolizing enzymes.
More specifically the aim included:- Developing ...
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Development of Cell-Based Assays for Adenine Receptors and Selected Purine Receptor Subtypes: Receptor Characterization and Search for Novel Ligands
Abdelrahman, Aliaa Mahmoud Mohamed Eltayb (2011-01-04)The thesis deals with the development of different cell-based assay techniques in order to characterize the receptors under investigation at the protein level, mapping of the distribution of the receptors of interest in ... -
The Development of Chiral Titanocenes as Photoredox Catalysts
Slak, Daniel (2023-01-24)This dissertation describes the advances in photochemically activated (chiral) titanocenes as both electron transfer and photoredox catalysts in epoxide opening reactions. Based on the discovery of the photoredox-active ... -
Development of Computational Methods for Rationalizing Chemical Lead Optimization and Compound Design
Yonchev, Dimitar (2021-09-22)Chemical lead optimization (LO) plays an important role in pharmaceutical drug discovery. It represents a highly complex multi-objective process, in which the ultimate goal is to identify a suitable candidate molecule that ... -
Development of depleted monolithic active pixel sensors for high rate and high radiation experiments at HL-LHC
Hirono, Toko (2019-07-10)Depleted monolithic active pixel sensors (DMAPS) are developed to demonstrate their suitability for high energy particle physics experiments in high radiation and high hit-rate environments. In this thesis, characterization ... -
Development of Efficient and Accurate Approximations to Single Reference Correlation Methods using Pair Natural Orbitals
Hansen, Andreas (2012-09-14)Computational chemistry greatly enhances the scientific analysis of experiments and can predict quantities that are experimentally not accessible. However, there is still no approximate method available that is both efficient ... -
Development of efficient tools for monitoring and improvement of biogas production
Refai, Sarah (2017-03-29)Biomass from energy crops and organic waste is one of the most important renewable energy sources and can be used for the production of biogas. Biogas formation is based on the fermentation of organic matter and is performed ... -
Development of Enzyme Replacement and Pharmacological Chaperone Approaches for Therapy of Metachromatic Leukodystrophy
Schuster, Tilman (2015-01-06)Metachromatic leukodystrophy (MLD) is a monogenic, autosomally recessively inherited lysosomal storage disease. Certain mutations of the arylsulfatase A (ASA) gene cause misfolding or absence of ASA. Physiologically ASA ...