E-Dissertationen: Browsing E-Dissertationen by Author "Walter, Jochen"
Now showing items 1-15 of 15
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The Effect of S1P-lyase Deficiency on the Metabolism of the Alzheimer’s related Amyloid Precursor Protein
Karaca, Ilker (2014-12-15)Alzheimer’s disease is neuropathologically characterized by intracellularly accumulated tau protein and by extracellular plaques, mainly composed of the small hydrophobic peptide amyloid β (Aβ). Sequential cleavage of the ... -
Extracellular Phosphorylation of the Amyloid β-Peptide Promotes Aggregation
Kumar H.S., Sathish (2009-07-21)Alzheimer’s disease (AD) is the most prevalent, progressive neurodegenerative disorder and its incidence is increasing with the aging population worldwide. The presence of extracelluar neuritic plaques containing amyloid ... -
Interplay between the amyloid precursor protein (APP) and α-secretases at the plasma membrane
Hitschler, Lisa (2022-04-21)Alzheimer’s disease (AD) is the most common form of dementia. A principle pathological feature of AD are senile plaques consisting of extracellular aggregations of amyloid β peptides (Aβ). Aβ is derived from the amyloid ... -
Intramembrane proteolysis of ephrin-B2 by γ-secretase regulates podosome dynamics and migration of microglia
Kemmerling, Nadja (2016-01-20)The Eph-ephrin system plays pivotal roles during development and adulthood in cell-cell interaction, cell adhesion and migration. It has previously been shown that ephrin-B1 and 2 can be cleaved intramembranously by the ... -
Involvement of autophagy in the metabolism of Amyloid Precursor Protein and effects of familial Alzheimer’s disease-associated mutations of Presenilin-1
Nguyễn, Thành Tiền (2014-12-01)Alzheimer’s disease (AD) is the most common form of neurodegenerative diseases, which is associated with extracellular deposits of the amyloid β-peptide (Aβ) and intraneuronal aggregates of hyperphosphorylated tau protein ... -
Molecular Mechanisms in the Unconventional Secretion of Insulin-Degrading Enzyme
Löchner, Marie (2018-04-12)Extracellular deposition of amyloid-ß (Aß) plaques in the brain, a hallmark of Alzheimer’s disease (AD), results from an imbalance between production and clearance of the peptide. Insulin-degrading enzyme (IDE) is one of ... -
Molecular Mechanisms of Aβ Peptide Aggregation and Interaction with Microglia via TREM2
Riffel, Florian Raphael (2024-01-22)Alzheimer’s disease (AD) is a progressive neurodegenerative disorder accompanied by a decline in cognitive functions. It is estimated that roughly 50 million people are currently suffering from AD, a number that is thought ... -
Regulatorische Funktion der Phosphorylierung von Neprilysin in der Lokalisation an der Plasmamembran und der Interaktion mit dem Tumorsuppressor PTEN
Siepmann, Martin (2010-04-23)Bei der Zink-Metalloendopeptidase Neprilysin (NEP) handelt es sich um ein Typ 2 Membranprotein, das für die Degradation von extrazellulären Peptiden und Peptidhormonen zuständig ist. Darüber hinaus kann NEP sowohl im ... -
A reporter cell system for TREM2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region
Ibach, Melanie Sandra (2021-06-08)The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on myeloid-derived cell types. The extracellular immunoglobulin-like domain of TREM2 binds anionic ligands including Apolipoprotein ... -
A role of Alzheimer’s disease-associated γ-secretase in lipid metabolism and lipid droplet formation via LXR activation
Gutierrez, Esteban (2021-06-29)The γ secretase is an intramembrane protease complex, essential for the processing of a wide variety of type-1 membrane proteins. Among these is the amyloid precursor protein (APP), a protein strongly linked to Alzheimer’s ... -
Role of membrane lipids in regulation of Alzheimer’s disease associated proteins and vice-a-versa
Tamboli, Irfan Yunus (2008)Alzheimer’s disease (AD) is associated with extracellular deposits of the amyloid β- peptide (Aβ) and intraneuronal aggregates of hyperphosphorylated tau protein in the brain. Aβ is generated by sequential proteolytic ... -
Role of presenilins in autophagy and growth factor signaling
Roeser, Sebastian Philip (2021-02-08)Alzheimer's disease is the most common neurodegenerative disease and affects millions of people worldwide. To date, no efficient therapies are known for a cure. As people suffering from diabetes mellitus type 2 have an ... -
Structural aspects of the plasmalemmal Amyloid Precursor Protein cluster
de Coninck, Dennis (2021-11-12)Alzheimer’s Disease (AD) is a major socio-economic threat to health care systems and society in general. Involvement of the amyloid-beta peptide (Aβ) and its parent, the amyloid precursor protein (APP), in AD seemed obvious ... -
TREM2 modulates differential deposition of post-translationally modified Aβ variants in the brain parenchyma and the vasculature
Joshi, Pranav Chintamani (2022-08-01)Alzheimer’s disease (AD) is characterized by the combined presence of extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) with abnormally phosphorylated tau (t) protein in the ... -
γ-Secretase mediated proteolytic processing of the triggering receptor expressed on myeloid cells-2: functional implications for intracellular signaling
Wunderlich, Patrick (2011-06-01)Alzheimer's disease (AD) is a progressive neurodegenerative disorder, affecting millions of people worldwide. AD is histopathologically characterized by the appearance of neurofibrillary tangles, which are intraneuronal ...