E-Dissertationen: Suche
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Nuclear export of single native mRNA molecules observed via light sheet fluorescence microscopy and transcriptional regulation of BR2.1 during heat-shock
(2015-01-06)
Eucaryotes store most of their genetic information in the nucleus. Parts of this information encode the amino acid sequence of proteins. To synthesize a protein according to the nucleotide sequence, first the corresponding ......
Entwicklung und Bewertung verschiedener Methoden zur Aktivitätsbestimmung von Ectonucleotidasen und zur Identifizierung von Inhibitoren
(2015-05-27)
Ectonucleotidasen werden ubiquitär im Körper exprimiert und sind an vielen (patho)physiologischen Prozessen beteiligt. Sie sind daher als potentielle Arzneistofftargets von großem Interesse (z. B. in der ...
Cluster analysis of European surface ozone observations for evaluation of MACC reanalysis data
(2015-04-22)
The high density of European surface ozone monitoring sites offers good opportunities for investigation of the regional ozone representativeness and for evaluation of chemistry climate models. In this thesis we analyze ...
Synthesis, Crystallography and Spectroscopy of dinuclear Gold(I) NHC Macrocycles
(2015-05-11)
The synthesis, crystallography and spectroscopy of seven systematic series of dinuclear coinage metal(I) NHC complexes are shown here. As counter ions, bromide and the bulkier hexafluorophosphate are studied. Both gold(I) ...
Heteronuclear Polycationic Clusters from Group 15 and 16 Elements Synthesized in Chlorido Gallate Melts
(2015-07-23)
Polycationic clusters are positively charged molecules made of main group elements. They are specially found in the groups 15 and 16 of the periodic table. The chemistry of these clusters began in 1798 when chalcogen ...
Synthese und Charakterisierung von planar chiralen 4,12- und 4,15-disubstituierten [2.2]Paracyclophanen, ihre Racematspaltung und Anwendbarkeit als Rückgratmoleküle für metallosupramolekulare Aggregate
(2015-02-13)
Eines der Hauptthemengebiete der Arbeitsgruppe Lützen ist die metallosupramolekulare Chemie. Hierbei geht es vor allem um die Selbstorganisation und in (chiralen) Mehrkomponentensystemen um die Selbsterkennung beziehungsweise ...
Distribution and genetic composition of carbapenem-resistance determinants in clinical Acinetobacter isolates – focus on carbapenem-hydrolysing β-lactamases
(2015-02-11)
Acinetobacter baumannii is of global concern in health-care facilities as it can easily thrive in the hospital environment and infections can be difficult to treat. Widespread multi-drug (MDR) resistance and a ...
Synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification
(2015-01-08)
The goal of this work was to establish methods for the synthesis of modified gangliosides that are suitable as internal standards for mass spectrometry. Quantification of gangliosides is usually achieved by staining after ...
Massenspektrometrische Analyse von enzymatisch-chemischen Verdaus zur Detektion vonPhotoaffinitätsmarkierungen des ABC-Transporters P-Glykoprotein
(2015-08-19)
Der ATP-binding cassette (ABC) Transporter P-Glykoprotein (P-gp) stellt den aus medizinischer Sicht wichtigsten humanen ABC-Transporter dar. Aufgrund seiner ubiquitären Expression in Geweben mit Barrierefunktion und ...
Synthesis and structure-activity relationships of α,β-methylene-ADP derivatives: potent and selective ecto-5-nucleotidase inhibitors
(2015-08-19)
Ecto-5'-nucleotidase (ecto-5'-NT, eN, CD73, EC 3.1.3.5) is a member of the group of ecto-nucleotidases which dephosphorylate extracellular nucleotides. eN catalyzes the dephosphorylation of nucleoside monophosphates and ......