E-Dissertationen: Search
Now showing items 1-10 of 11
Characterization of cellular functions of the deubiquitinating enzyme OTUD4
(2020-08-10)
Post-translational modification of proteins with ubiquitin influences myriad of cellular processes by affecting protein stability, degradation, localization and protein-protein interactions. Ubiquitin gets transferred to ...
Computation of Mass Spectra Using Quantum Chemical Methods
(2022-11-23)
Mass spectrometry (MS) is widely used for the structural elucidation of compounds in a vast variety of scientific research. Unfortunately, many methods that aim to predict mass spectra cannot often elucidate the complete ...
Development and Application of Automated Quantum Chemical Workflows for the Computation of Non-Covalent Interactions and Mass Spectra
(2025-12-16)
The topic of this thesis is to advance the automated and efficient quantum chemical description of chemical systems, with a particular focus on non-covalent interactions (NCIs) and mass spectrometry (MS). In Chapter 1, ...
Relevanz hinweisgebender Verfahren und Einfluss präanalytischer Variablen auf die Befundinterpretation forensisch-toxikologischer Fragestellungen
(2025-11-25)
Die forensisch-toxikologische Beurteilung basiert auf der objektiven und validen Erfassung von Substanzen in verschiedenen Matrizes. Die Erhebung von Messwerten gliedert sich dabei in die präanalytische und analytische ......
Investigation of the lysosomal proteome in neuronal ceroid lipofuscinosis caused by CLN6 deficiency and interactome studies to identify novel interaction partners of CLN6
(2024-07-29)
Neuronal ceroid lipofuscinoses (NCLs) account for the majority of genetic neurodegenerative diseases in infancy. However, for most forms of this serious disease there is no adequate treatment available. In the NCL6 subtype, ...
Proteomic identification of posttranslational modifications: cAMP-induced changes of phosphorylation and investigation of novel approaches detecting posttranslational modifications at lysine and arginine residues
(2020-04-22)
Cyclic adenosine monophosphate (cAMP) is an important second messenger which can be generated in response to signals binding to stimulatory G-protein coupled receptors. Inside the cell, protein kinase A is a well-known ...
Mechanistic investigations of organocatalytic and gold-catalyzed reactions and synthetic approach towards a chiral bifunctional catalyst
(2023-05-09)
The first part of this thesis focuses on the mechanistic studies of an intermolecular cyclization reaction between an α,β-unsaturated aldehyde and an electron deficient primary alkyne to a cyclopentene carbaldehyde. Based ......
Mechanistic Investigation of a HAuCl4 catalyzed oxidative C-C coupling reaction and Synthesis of new supramolecular Silver(I) and Gold(I) NHC compounds: or handling of a Mass Spectrometric Challenge and catching Counterions on Supramolecular Playgrounds
(2021-04-22)
Reaction monitoring by electrospray (ESI) mass spectrometry is a valuable technique to investigate reaction mechanisms. It allows a glimpse into the reacting solution and the characterization of transient intermediates ......
Analyse der Thermostabilität mitochondrialer Proteine anhand der Protein-Disaggregation durch Hsp78 in Bäckerhefe
(2021-02-11)
Alle Organismen zeichnen sich durch spezifische auf ihre Lebensbedingungen angepasste Charakteristika aus. Hefen, darunter auch die Bäckerhefe Saccharomyces cerevisiae, besitzt eine Vielzahl an spezialisierten Proteinen, ...
Mass spectrometric analysis of short-lived intermediates and ancient fossils
(2021-06-14)
The first part of this thesis focuses on mechanistic studies of two L-proline catalyzed reactions with electrospray ionization mass spectrometry. The second part describes mass spectrometric analyses of fossils, dinosaur ...
