The focus of this work was to elucidate the contribution of a single Na⁺ channel a-subunit, namely Na_V1.6, to the discharge properties of CA1 pyramidal neurons. In the first part of this work, we show ...

The human disease of metachromatic leukodystrophy (MLD) is caused by a single or multiple allelic mutations within the gene locus of arylsulfatase A (ASA). This protein is a lysosomal enzyme catalyzing the degradation of ...