eDissertationen: Suche
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RIMs and RIM interacting proteins: localization and function under physiological and pathophysiological conditions
(2011-02-25)
Neurons transmit signals to their target cells at specialized contact sites called synapses. At chemical synapses the signal propagation is mediated by the fusion of neurotransmitter filled synaptic vesicles with the ...
Copy number variations of the mitochondrial DNA as potential cause of mitochondrial diseases
(2010-12-30)
Aim: The aim of this thesis was the analysis of copy number variations of the mitochondrial DNA (mtDNA) in several tissues and cell types with regard to different mitochondrial associated disorders.<br /> Background: The ...
Charakterisierung der Stärke und Richtung von Interaktionen zwischen dynamischen Systemen mit Zellularen Neuronalen Netzen
(2010-09-01)
In der vorliegenden Dissertation werden Stärke und Richtung von Interaktionen zwischen komplexen dynamischen Systemen mit Zellularen Neuronalen Netzen (CNN) erfolgreich charakterisiert. Die Berechnung von Kenngrößen zur ...
Inferring complex networks from time series of dynamical systems: Pitfalls, misinterpretations, and possible solutions
(2012-07-26)
Understanding the dynamics of spatially extended systems represents a challenge in diverse scientific disciplines, ranging from physics and mathematics to the earth and climate sciences or the neurosciences. This challenge ...
Komplexe dynamische Systeme als funktionelle Netzwerke: Möglichkeiten und Grenzen der datengetriebenen Analyse
(2012-03-12)
Aus einer Vielzahl von Subsystemen zusammengesetzte dynamische Systeme können als Netzwerk aufgefasst und mit Methoden der Graphentheorie beschrieben werden. Innerhalb dieses Ansatzes werden die Subsysteme durch Knoten und ...
The contribution of the sodium channel subunit Na<sub>V</sub>1.6 to neuronal excitability
(2010-04-13)
The focus of this work was to elucidate the contribution of a single Na<sup>+</sup> channel a-subunit, namely Na<sub>V</sub>1.6, to the discharge properties of CA1 pyramidal neurons. In the first part of this work, we show ...
Symbolische Transferentropie: Charakterisierung gerichteter Interaktionen in nichtlinearen dynamischen Netzwerken
(2011-01-11)
Im Rahmen der vorliegenden Arbeit wird untersucht, inwiefern eine Charakterisierung der Kopplungsrichtung zwischen komplexen dynamischen Systemen mit einer auf Konzepten der nichtlinearen Dynamik, der Informationstheorie ...
Synaptic vesicle protein 2A (SV2A) and connexin 43 (Cx43) as targets for epilepsy: establishment of assays and identification of ligands
(2017-09-12)
Epilepsy is a chronic neurological disorder affecting around 1% of the human population worldwide. The antiepileptic drugs (AEDs) available on the market provide symptomatic relief from epilepsy but do not cure the disease. ...
Mechanisms of memory consolidation: Analyzing the coordinated activity of concept neurons in the human medial temporal lobe during waking and sleep
(2018-12-11)
The aim of this thesis is to investigate the role of human concept neurons in memory consolidation during sleep. Memory consolidation is a process by which memories initially dependent on the hippocampus are transferred ...
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...
