E-Dissertationen: Search
Now showing items 11-20 of 49
FR900359, an inhibitor of guanine nucleotide dissociation, effectively blunts signaling of GTPase-deficient Gq: mechanism of action and relevance for treating Gq-driven cancers
(2019-08-01)
Uveal melanoma (UM), the most common cancer of the adult eye, is known to have poor prognosis. Over 50% of patients are likely to develop metastasis. In more than 80% of the cases UM is driven by an activating mutation in ...
Impact of ERK signaling and its spatial regulation on cisplatin sensitivity in ovarian cancer cells
(2019-11-08)
The efficiency of the anticancer drug cisplatin in ovarian cancer is often limited by the development of cisplatin resistance. Cisplatin activates a plethora of DNA damage-related signaling pathways, which regulate the ...
Application and Development of Mass Spectrometry-based Approaches to Investigate the Regulation of Lysosomal-associated Proteins by Phosphorylation
(2019-11-12)
Phosphorylation is one of the most abundant and best studied posttranslational modifications in mammalian cells and refers to the addition of a phosphate group to an amino acid residue of a protein. Phosphorylation can ...
Molecular and functional characterization of inflammation-induced cell state transitions in malignant-transformed melanocytes
(2019-10-08)
Cellular phenotype plasticity is a hallmark of embryonic development in order to achieve cell type specification from precursor populations. The molecular mechanisms orchestrating phenotypic plasticity are of interest ......
Platelet-immune cell interactions in inflammation and cancer
(2019-09-10)
Platelets are well-known for their role in hemostasis and only more recently, they have also been acknowledged for their immune regulatory roles. Despite being small sized and anucleated, they can respond to inflammatory ...
The differential regulation of podosome formation by Cytohesin-2 is mediated via α5β1 integrin and the small GTPase RhoA
(2019-09-25)
The interaction of a cell with the surrounding tissue is crucial not only to provide mechanical stability but also to enable adaptation of cellular responses to the environment. Recognition of extracellular matrix (ECM) ...
Quantitative proteome analysis of S-nitrosylation on synaptosomal proteins in Alzheimer's disease
(2019-08-28)
Alzheimer's disease (AD) is an irreversible, progressive and most common type of dementia in the aging population. AD pathophysiology starts slowly and deteriorates over time before the clinical diagnosis of dementia can ...
Characterization of VKORC1L1 with respect to VKORC1
(2019-07-10)
Vitamin K reduction is essential and catalyzed by two enzymes in vitro. Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) reduces vitamin K to sustain γ-carboxylation of vitamin K dependent (VKD) proteins. This ...
Evaluation of protective immune responses against Litomosoides sigmodontis and analysis of L. sigmodontis extract on T cell modulation and glucose tolerance in diet-induced obese mice
(2019-11-11)
Parasitic helminths are responsible for numerous tropical diseases which represent a major health problem in tropical and subtropical regions such as lymphatic filariasis (elephantiasis), causing lymphedema in limbs and ......
Parasitäre Helminthen sind für eine Vielzahl von tropischen Krankheiten verantwortlich, die ein großes Gesundheitsproblem in den Tropen und Subtropen darstellen. Bei der lymphatischen Filariose (Elephantiasis) leiden ......
Parasitäre Helminthen sind für eine Vielzahl von tropischen Krankheiten verantwortlich, die ein großes Gesundheitsproblem in den Tropen und Subtropen darstellen. Bei der lymphatischen Filariose (Elephantiasis) leiden ......
Actin Regulatory Proteins in Dendritic Arborisation Neurons of Drosophila
(2019-10-23)
Dendrites are highly branched extensions of nerve cells, along which signals are received and propagated to the cell body. The correct morphology of dendrites is essential for the function of the nervous system. The ...