Now showing items 211-218 of 218
Studies on the Biosynthesis and Structure Elucidation of Terpene Natural Products by Isotopic Labeling Experiments
The cumulative doctoral thesis "Studies on the Biosynthesis and Structure Elucidation of Terpene Natural Products by Isotopic Labeling Experiments" deals with the application of stable isotopes for structure elucidation ...
Design, synthesis and optimization of nucleotide-derived inhibitors and probes for the ecto-nucleotidases CD39 and CD73
(noch nicht zugänglich / not yet accessible)
Application and Development of Mass Spectrometry-based Approaches to Investigate the Regulation of Lysosomal-associated Proteins by Phosphorylation
Phosphorylation is one of the most abundant and best studied posttranslational modifications in mammalian cells and refers to the addition of a phosphate group to an amino acid residue of a protein. Phosphorylation can ...
Biochemical characterization, regulation, and inhibition of human transcription kinases CDK12 and CDK13 and human cell cycle-related kinase CDK14
The transcription process is the first step in the molecular information flow from genome to proteome. In eukaryotes, the RNA polymerase II (RNAPII) transcribes genes that code for proteins by synthesizing pre-mature ...
Establishment of anti-apoptotic brakes in human neurons during maturation
Neurons represent a highly specialised cell population of the central and peripheral nervous system, which is responsible for spreading information throughout the body. They are born during embryonic development and persist ...
Pharmacometric approaches for linking pharmacokinetic and pharmacodynamic models of sunitinib and pazopanib with clinical outcome
Aim of this thesis was to build a modeling framework for patients with metastatic renal cell carcinoma (mRCC) treated with two common first-line therapies, sunitinib and pazopanib. Therefore, as part of the European-wide ...
Untersuchungen zur Biogenese des Protoanemonins
Verschiedene potentielle C-14 markierte Precursor wurden an Helleborus foetidus Pflanzen appliziert. Durch Wasserdampfdestillation wurde Protoanemonin gewonnen, durch Aufarbeitung mittels verdünnter Salzsäure wurden andere ...