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Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...
Improved Cardinality Bounds for Rectangle Packing Representations
(2019-05-29)
Axis-aligned rectangle packings can be characterized by the set of spatial relations that hold for pairs of rectangles (west, south, east, north). A representation of a packing consists of one satisfied spatial relation ...
Development of depleted monolithic active pixel sensors for high rate and high radiation experiments at HL-LHC
(2019-07-10)
Depleted monolithic active pixel sensors (DMAPS) are developed to demonstrate their suitability for high energy particle physics experiments in high radiation and high hit-rate environments. In this thesis, characterization ...
Dynamics of Open Quantum Systems
(2019-06-13)
Remarkable experimental progress and theoretical advancements in the study of strongly corre- lated systems have opened up new doors towards a better understanding of interesting states of matter. Such states could possibly ...
Model-based formulation of amorphous solid dispersions made by hot-melt extrusion
(2019-08-21)
Regarding hot-melt extrusion in early pharmaceutical formulation and process development, techniques and procedures are needed to simplify the application of hot-melt extrusion (HME) and to decrease the effort in terms of ......
Massive filamentary clouds and their role in star formation
(2019-05-27)
Filamentary structures are ubiquitous in the interstellar medium of the Milky Way. They are observed at a large range of size-scales from ~ 1 pc within star-forming and quiescent molecular clouds to ~ 100 pc representing ...
Das Schnauzenorgan des schwach elektrischen Fischs Gnathonemus petersii: Anatomie, neuronale Innervation und senso-motorische Integration
(2019-05-14)
Eine besondere Struktur des schwach elektrischen Mormyriden Gnathonemus petersii ist sein hoch mobiler, vermutlich multisensorischer Kinnfortsatz, das Schnauzenorgan. Seine einzigartige Funktion als elektrische Fovea für ...
Indexe auf verschlüsselten Daten: Konzepte, Performanz, Sicherheitsaspekte
(2019-05-02)
Diese Dissertation befasst sich mit Informationssystemen mit nicht vertrauenswürdiger Serverseite. Für solche Systeme bietet sich eine clientseitige Verschlüsselung ihrer Daten an, um hohe Anforderungen an deren Vertraulichkeit ......
Expanding the toolbox of modified nucleobases and click chemistry for investigations on non-coding RNA
(2019-05-20)
Non-coding ribonucleic acid (RNA) consists of highly structured molecules whose arrangement and function can be investigated using different chemical labeling approaches. Contemporary labeling techniques show restrictions ...
Click-SELEX enables the selection of Δ9-tetrahydrocannabinol-binding nucleic acids
(2019-05-10)
Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...