E-Dissertationen: Suche
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Formulierung von therapeutischen Oligonukleotiden mit PAMAM-Dendrimeren zur Aktivierung von Pattern Recognition Rezeptoren des angeborenen Immunsystems
(2019-05-03)
Der ubiquitär exprimierte Immunrezeptor Retinoic Acid inducible Gene-I, kurz RIG-I, ist eine zytosolisch lokalisierte Helikase, die zur Detektion von pathogenen RNA-Viren befähigt ist. Als synthetischer Ligand konnte eine ......
Computational Analysis of Assay Interference and Compound Promiscuity in Medicinal Chemistry
(2019-06-21)
Compound promiscuity offers both opportunities and perils for medicinal chemistry and drug discovery. On the one hand, it is well-established that compounds elicit their therapeutic potential by engaging with multiple ...
Identification of new molecular targets and antibiotics as novel strategies against filarial infections: Characterization of lipid II biosynthesis in Wolbachia endobacteria
(2019-06-05)
Wolbachia are obligate intracellular bacteria found in many arthropods and some filarial nematodes that are pathogenic in humans. The Wolbachia genomes are highly reduced, but encode proteins required for the synthesis of ......
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...
Click-SELEX enables the selection of Δ9-tetrahydrocannabinol-binding nucleic acids
(2019-05-10)
Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...
Microglial Activation in Alzheimer's Disease
(2019-06-05)
Alzheimer's disease (AD) is the most prevalent type of dementia and characterized by the deposition of extracellular amyloid-beta (Aβ) and tau hyper-phosphorylation. Over the past decade, neuroinflammation has emerged as ...
Knowledge Management approaches to model pathophysiological mechanisms and discover drug targets in Multiple Sclerosis
(2019-04-30)
Multiple Sclerosis (MS) is one of the most prevalent neurodegenerative diseases for which a cure is not yet available. MS is a complex disease for numerous reasons; its etiology is unknown, the diagnosis is not exclusive, ...
Patientenspezifische induziert pluripotente Stammzellen als Modellsystem zur Untersuchung der lysosomalen Speichererkrankung Metachromatische Leukodystrophie
(2019-02-14)
Die Metachromatische Leukodystrophie (MLD) wird verursacht durch eine funktionelle Defizienz des metabolischen Enzyms Arylsulfatase A (ARSA). Unter physiologischen Bedingungen baut ARSA das Membranlipid 3'-O-Sulfo-Galakt ......