E-Dissertationen: Search
Now showing items 21-30 of 31
Pharmacological reprogramming of macrophages through aptamiRs
(2020-03-05)
Nucleic acid-based molecules have certain advantages over conventional drugs or protein-based target approaches. Chemically synthetized nucleic acids-based molecules are known as aptamers. They are selected from a combinatorial ...
Investigations into side chain assembly and attachment during biosynthesis of the G protein inhibitor FR900359
(2021-06-07)
The natural product FR900359 (FR) selectively inhibits Gaq proteins and thus intracellular signalling of many G protein-coupled receptors. This unique mechanism of action makes FR an indispensable pharmacological tool to ......
The role of guanine nucleotide exchange factors (GEFs) in EGF-receptor signalling: Screening for a small molecule inhibitor of the Rin1-mediated Rab5 activation
(2018-06-04)
The small GTPase Rab5 is a key regulator of early endosomal trafficking. It functions as a molecular switch that can be activated by guanine nucleotide exchange factors (GEFs) and inactivated via hydrolysis of GTP with the ...
Funktionelle Untersuchungen des ABC-Transporters ABCG2
(2021-10-15)
Das Phänomen der Multidrug Resistance (MDR) stellt ein bedeutsames Problem bei der Behandlung von Tumoren mit Chemotherapeutika dar. Die ABC-Transporter ABCB1, ABCC1 und ABCG2 sind an der Entstehung der MDR beteiligt. ...
Zebrafish as a Model Organism to Study the In Vivo Role of G-Protein Coupled Receptor 17 in Myelination
(2019-02-26)
The sheathing of axons with myelin by oligodendrocytes constitutes a necessity for sufficient and rapid nerve conduction within the vertebrate central nervous system (CNS). However to date, the complex molecular mechanisms ...
Genome mining of marine bacteria for bioactive metabolites
(2019-02-04)
Marine bacteria have come into the focus for natural product discovery as a consequence of the emergence of antibiotic resistance. This was additionally boosted by the limitations encountered in drug developments from ...
Bioinformatische und in-vitro-Analyse der frs-Biosynthesegencluster von Cand. Burkholderia crenata und Chromobacterium vaccinii
(2019-07-03)
FR900359 (FR) ist ein selektiver Gq-Proteininhibitor, der ursprünglich aus der Pflanze Ardisia crenata isoliert wurde. G-Proteine spielen eine zentrale Rolle in der Signalübertragung von G-Protein ......
Carvedilol-mediated signal transduction at the β2 adrenergic receptor
(2022-07-14)
G protein-coupled receptors (GPCRs) comprise the most prominent family of membrane proteins in the mammalian genome. They are required to relay extracellular cues into a cellular response. The environmental interactions ...
On the enigmatic mechanism of signal transduction of "arrestin-biased" angiotensin peptides: spotlight on endogenous angiotensin 1-7
(2024-02-27)
(noch nicht zugänglich / not yet accessible)