E-Dissertationen: Search
Now showing items 3271-3280 of 4070
Inhibitory Circuits of the CA3-Dentate Gyrus System
(2021-11-04)
Neuronal inhibition is an essential feature of all brain areas. Besides controlling the average rate of neuronal firing, it also controls the precise timing of action potentials and mediates several types of network ...
External Spanier-Whitehead duality for C-spectra and applications to C-homology theories
(2021-07-19)
The thesis constructs a Spanier-Whitehead type duality functor relating finite C-spectra to finite Cop-spectra, where C is a topological index category. We prove that every C-homology theory is given by taking the homotopy ...
Role of presenilins in autophagy and growth factor signaling
(2021-02-08)
Alzheimer's disease is the most common neurodegenerative disease and affects millions of people worldwide. To date, no efficient therapies are known for a cure. As people suffering from diabetes mellitus type 2 have an ...
Experimental studies on small diameter carbon dioxide evaporators for optimal Silicon Pixel Detector cooling
(2020-12-18)
Since recent years the Large Hadron Collider at CERN and its experiments are the subject of upgrade programs, which are necessary to increase the foreseen collision rates and the amount of data to be gathered for the ...
The Transient Radio Sky: Pulsars and Fast Radio Bursts
(2021-09-17)
This thesis focuses on targeted searches of two radio transients associated with neutron stars (NS): Pulsars and Fast Radio Bursts (FRBs), and the study of their properties over different timescales. Pulsars emit beams of ...
OptoRiboGenetics: Post-transcriptional control of gene expression by light
(2021-08-26)
Gene expression is tightly regulated in mammalian cells at the post transcriptional level and its precise manipulation has proven to be valuable for protein overexpression and gene therapy. Implementation of light-responsive ......
OptoRiboGenetics - Posttranskriptionelle Kontrolle der Genexpression mit Licht
Die Genexpression von Säugetierzellen wird maßgeblich auf post-transkriptioneller Ebene reguliert und das Eingreifen auf ......
OptoRiboGenetics - Posttranskriptionelle Kontrolle der Genexpression mit Licht
Die Genexpression von Säugetierzellen wird maßgeblich auf post-transkriptioneller Ebene reguliert und das Eingreifen auf ......
Exploring Non-Equilibrium in Ultracold Fermi Gases and Machine Learning in Physics
(2021-05-21)
This thesis covers two fields of research carried out in the context of ultracold Fermi gases: Non-equilibrium physics in the BEC-BCS crossover and the use of machine learning methods in physics.
The BEC-BCS ...
The BEC-BCS ...
Investigations into side chain assembly and attachment during biosynthesis of the G protein inhibitor FR900359
(2021-06-07)
The natural product FR900359 (FR) selectively inhibits Gaq proteins and thus intracellular signalling of many G protein-coupled receptors. This unique mechanism of action makes FR an indispensable pharmacological tool to ......
The Role of microRNAs in the Regulation of Human UDP-glucuronosyltransferases (UGTs)
(2021-06-14)
The liver is involved in endo- and xenobiotic metabolism due to the expression of drug-metabolizing UDP-glucuronosyltransferases (UGTs). By UGT-mediated elimination of hazardous compounds and other reactive metabolites, ...
Investigation of Quinazoline Derivatives as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)
(2018-03-12)
The treatment of cancer with chemotherapeutic drugs is strongly limited by intrinsic or aquired resistance of the cancer cells. This is the main reason of a failure of the therapy. The cellular resistance mostly originates ...