E-Dissertationen: Suche
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Music Synchronization, Audio Matching, Pattern Detection, and User Interfaces for a Digital Music Library System
(2013-07-11)
Over the last two decades, growing efforts to digitize our cultural heritage could be observed. Most of these digitization initiatives pursuit either one or both of the following goals: to conserve the documents - especially ...
Establishment of predictive blood-based signatures in medical large scale genomic data sets: Development of novel diagnostic tests
(2013-07-16)
Increasing data has led to tremendous success in discovering molecular biomarkers based on high throughput data. However, the translation of these so-called genomic signatures into clinical practice has been limited. The ...
Characterization of drought stress regulator CBF/DREB genes in Hordeum vulgare: Expression analysis in ten different barley cultivars
(2013-07-08)
Improving crop yield under water deficit environments is an urgent task for crop breeding worldwide. Many efforts have been made to identify key regulators of plant drought stress responses. Most of these studies have been ......
The role of the CC chemokine CCL17 in a mouse model of Alzheimer’s disease
(2013-07-25)
In Alzheimer's disease (AD), inflammatory processes are critically involved by cells releasing neurotoxic or neurotrophic factors influencing survival of neurons and synapses, and thereby cognitive behavior. Several ...
Vegetation and climate history of the southern Levant during the last 30,000 years based on palynological investigation
(2013-07-09)
Paleo-vegetation of northern Israel is reconstructed from palynological data over the Late Pleistocene and Holocene, and related to climate variation in the Levant, as well as anthropogenic impact on vegetation. Being ...
Analytik und Eignung von Biomarkern zur Vorhersage der Wirksamkeit von Sunitinib mit Hilfe von pharmakokinetischen/pharmakodynamischen Modellen
(2013-05-07)
Im Rahmen der Dissertation sind die Analytik und die Eignung von Biomarkern (sVEGFR 2 und -3) zur Vorhersage der Wirksamkeit von Sunitinib mit Hilfe der PK/PD-Modellierung in einer multizentrischen Studie bei Patienten mit ...
Target-based discovery of novel inhibitors of enzymatic targets from Wolbachia endosymbionts and evaluation as antifilarial drug candidates
(2013-07-24)
Filarial nematodes are the causative agents of vector-borne diseases known as lymphatic filariasis and onchocerciasis. More than 150 million inhabitants of endemic tropical and subtropical countries are infected and may ......
Peroxisomen-Biogenese und -Physiologie: Rolle des konservierten Pex19 Proteins im Modellorganismus Drosophila
(2013-07-08)
Peroxisomen sind obligatorische Zellorganellen der Eukaryoten. Neben α- und β-Oxidation von Fettsäuren, vermitteln sie den Abbau von Purinen und reaktiven Sauerstoffspezies. Defekte der Peroxisomen-Biogenese können zu ...
Development of New Breast Cancer Resistance Protein Inhibitors
(2013-07-09)
Chemotherapy is a major form of treatment for cancers. Unfortunately, the majority of cancers are either resistant to chemotherapy or acquire resistance (MDR) during treatment. The most common mechanism by which human ...
Microarrayanalyse gynäkologischer Tumorentitäten
(2013-07-10)
Softwareentwicklung Die Analyse von Genexpressionsprofilen fällt nicht länger exklusiv in den Aufgabenbereich von Bioinformatik Experten. Jedoch gestaltet sich der Erhalt von statistisch signifikanten Resultaten schwierig ......