E-Dissertationen: Search
Now showing items 31-40 of 303
Functional characterization of the 5-oxo-ETE receptor OXE-R and identification of the first small molecule antagonist with a novel mechanism of ligand bias
(2011-10-21)
The lipid mediator 5-oxo-ETE (OXE) is a metabolite of the 5-lipoxygenase pathway and acts as a potent chemoattractant on eosinophils and neutrophils. OXE-induced effects are mediated via the Gi coupled 5-oxo-ETE ...
Mechanismen der hepatischen Immunregulation
(2011-10-21)
Die Leber vermittelt als immunmodulatorisches Organ einerseits eine periphere Immun-Toleranz, muss aber andererseits bei einer Infektion gleichzeitig die Induktion einer Immunantwort zulassen, die in der Lage ist, infizierte ......
Development of Selective Nitrile Inhibitors and ‘Activity-Based’ Probes For Human Cathepsins K and S
(2012-06-20)
Cysteine cathepsins show a high degree of similarity and play a significant role in many (patho)physiological processes such as bone remodeling, antigen presentation, osteoporosis, autoimmune disorders, and cancer. Therefore, ...
Beteiligung ATP-abhängiger Transportprozesse an der Resistenz gegenüber Platinkomplexen
(2012-08-10)
Eine reduzierte zelluläre Kumulation von Cisplatin ist ein häufig beobachteter Mechanismus der Platinresistenz. Es wird vermutet, dass neben der passiven Diffusion auch verschiedene energieabhängige Proteine, welche die ...
Experimental and numerical studies on solute transport in unsaturated heterogeneous porous media under evaporation conditions
(2012-08-31)
Groundwater level rise, root water uptake, or evaporation induces local upward water and solute fluxes in soils, causing soil salinization and rise of contaminants to the soil surface, and influencing the migration of ...
Characterization of the role of Hydroxyprostaglandin dehydrogenase 15-(NAD) in human regulatory T cells
(2012-06-14)
The focus of the present study was the characterization of the hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) in CD4+CD25+ regulatory T cells (Treg) concerning its regulation and role for the development and suppressive ...
Systematic analysis of the synaptic recruitment and activation kinetics of presynaptic inhibitory group II metabotropic glutamate receptors
(2012-08-22)
Pharmacological activation of presynaptic inhibitory group II mGluRs potently modulates excitatory synaptic transmission throughout the brain. However, little is known about the physiological conditions under which these ...
L-Proline and Glutamatergic Neurotransmission: Clarifying the Modulatory Role of Neuronal L-Proline Transporter
(2012-06-20)
The neuronal high affinity L-proline transporter (PROT) is a putative neurotransmitter transporter whose contribution to neurotransmission is still unknown. PROT is expressed exclusively in brain by subpopulations of ......
Control of neuronal input-output coupling by recurrent inhibition in the hippocampus
(2012-07-19)
During different states of hippocampal network activity neurons receive excitatory synaptic input on dendritic compartments and transform it into axonal action potential output. The ensemble output of pyramidal neurons ...
Modulation enzymatischer Stickoxidsynthasen in zellulären und murinen Modellen der Alzheimer-Krankheit
(2012-06-06)
Die induzierbare Form der Stickoxidsynthase (iNOS) wird bei entzündlichen Stimuli transkriptionell hochreguliert und kann in Gehirnen von Patienten mit Morbus Alzheimer (AD; „Alzheimer’s disease“, auch Alzheimer-Demenz) ...