E-Dissertationen: Suche
Anzeige der Dokumente 461-470 von 627
Climate field reconstructions from pollen and macrofossil syntheses using Bayesian hierarchical models
(2020-01-09)
Studying past climate states is important to understand climate changes and climate variability on centennial to orbital timescales, to analyze the reaction of the Earth system to large-scale changes in external forcings, ...
Generation and Applications of Knowledge Graphs in Systems and Networks Biology
(2019-12-16)
The acceleration in the generation of data in the biomedical domain has necessitated the use of computational approaches to assist in its interpretation. However, these approaches rely on the availability of high quality, ...
Untersuchungen zur Radionuklidbereitstellung von Fluor-18 für die Synthese von 18F-markierten PET-Tracern mit Hilfe von automatisierter fluider Synthesetechnik
(2019-12-16)
Für die Diagnostik von Stoffwechselerkrankungen wird die Positronenemissionstomographie (PET) unter Einsatz von spezifischen 18F Radiopharmaka genutzt. Neben etablierten Radiopharmaka wie beispielsweise ...
Computational Analysis of Pathophysiological Mechanisms Based on Pathway Modeling
(2019-12-18)
The advent of the big data era poses major challenges to the biomedical domain. First, it is necessary to adopt strategies that integrate and link the heterogeneous resources that contain multiscale and multimodal data in ...
Biochemical characterization, regulation, and inhibition of human transcription kinases CDK12 and CDK13 and human cell cycle-related kinase CDK14
(2019-11-27)
The transcription process is the first step in the molecular information flow from genome to proteome. In eukaryotes, the RNA polymerase II (RNAPII) transcribes genes that code for proteins by synthesizing pre-mature ...
Optogenetics in striated muscle: defibrillation of the heart and direct stimulation of skeletal muscles with light
(2019-12-16)
Optogenetic depolarization of cells using the non-selective cation channel Channelrhodopsin-2 (ChR2) enables precise control over the membrane potential of cells within a specific area of intact organs. Furthermore, the ......
The role of Cysteine-rich with EGF-like domains 2 in the maintenance of metabolic homeostasis and regulation of the unfolded protein response
(2019-12-17)
Das Ziel dieser Arbeit war es, die Rolle von Creld2 bei der Aufrechterhaltung der metabolischen Homöostase unter Normalbedingungen und bei der Regulation der UPR unter ER Stressbedingungen zu untersuchen. Metabolische ...
K-K and π-K Scattering Lengths at Maximal Isospin from Lattice QCD
(2019-08-02)
The current work presents calculations of the elastic scattering length a0 for systems of two Kaons and one pion and one Kaon, respectively. The values for a0 have been obtained from lattice QCD ......
Structural conformational analysis of molecular dynamics of a P-glycoprotein homology model and generated intermediate structures
(2019-10-02)
The major reason for failure of chemotherapy in cancer is multidrug resistance. A mechanism by which human cancers develop multi-drug resistance is over expression of certain ATP-binding cassette (ABC) transporters. ...
Effects of intracranial stimulation and the involvement of the human parahippocampal cortex in perception
(2019-10-04)
How the human brain translates photons hitting the retina into conscious perception remains an open question. Throughout the medial temporal lobe (MTL), there are neurons (called concept cells) that change their firing ...