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Identification of new molecular targets and antibiotics as novel strategies against filarial infections: Characterization of lipid II biosynthesis in Wolbachia endobacteria
(2019-06-05)
Wolbachia are obligate intracellular bacteria found in many arthropods and some filarial nematodes that are pathogenic in humans. The Wolbachia genomes are highly reduced, but encode proteins required for the synthesis of ......
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...
Das Schnauzenorgan des schwach elektrischen Fischs Gnathonemus petersii: Anatomie, neuronale Innervation und senso-motorische Integration
(2019-05-14)
Eine besondere Struktur des schwach elektrischen Mormyriden Gnathonemus petersii ist sein hoch mobiler, vermutlich multisensorischer Kinnfortsatz, das Schnauzenorgan. Seine einzigartige Funktion als elektrische Fovea für ...
Click-SELEX enables the selection of Δ9-tetrahydrocannabinol-binding nucleic acids
(2019-05-10)
Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...
Ceramide Synthase in Transcriptional Regulation and Lipid Sensing
(2019-05-20)
Ceramide synthases (CerS) are highly conserved transmembrane proteins necessary for sphingolipid biosynthesis. CerSs carry a TLC (Tram-Lag1-CLN8) domain, containing a conserved Lag1p motif required for ceramide synthesis. ......
Ceramid-Synthasen (CerS) sind hochkonservierte Transmembranproteine, die für die Sphingolipid-Biosynthese notwendig sind. CerSs tragen eine TLC (Tram-Lag1-CLN8)-Domäne, die ein konserviertes Lag1p-Motiv enthält, das für ......
Ceramid-Synthasen (CerS) sind hochkonservierte Transmembranproteine, die für die Sphingolipid-Biosynthese notwendig sind. CerSs tragen eine TLC (Tram-Lag1-CLN8)-Domäne, die ein konserviertes Lag1p-Motiv enthält, das für ......
Microglial Activation in Alzheimer's Disease
(2019-06-05)
Alzheimer's disease (AD) is the most prevalent type of dementia and characterized by the deposition of extracellular amyloid-beta (Aβ) and tau hyper-phosphorylation. Over the past decade, neuroinflammation has emerged as ...
The influence of ischemic pre-conditioning and inhibition of the ubiquitin proteasome system on cardiac ischemic injury in a murine model
(2019-04-30)
Myocardial infarction (MI) is a state when the flow of blood stops in a coronary artery or a succeeding vessel resulting in hypoxia leading to damage in the downstream cardiac tissue. Ischemia/reperfusion (I/R) injury leads ...
Patientenspezifische induziert pluripotente Stammzellen als Modellsystem zur Untersuchung der lysosomalen Speichererkrankung Metachromatische Leukodystrophie
(2019-02-14)
Die Metachromatische Leukodystrophie (MLD) wird verursacht durch eine funktionelle Defizienz des metabolischen Enzyms Arylsulfatase A (ARSA). Unter physiologischen Bedingungen baut ARSA das Membranlipid 3'-O-Sulfo-Galakt ......