E-Dissertationen: Search
Now showing items 1-10 of 11
Identification, optimization and characterization of pharmacological tools for the cannabinoidactivated orphan G protein-coupled receptor GPR18 and related receptors
(2017-12-21)
Cannabinoid receptors comprise two classical subtypes, CB1 and CB2, which belong to the large family of G protein-coupled receptors (GPCRs). They are the major targets of cannabinoids such as ......
Synaptic vesicle protein 2A (SV2A) and connexin 43 (Cx43) as targets for epilepsy: establishment of assays and identification of ligands
(2017-09-12)
Epilepsy is a chronic neurological disorder affecting around 1% of the human population worldwide. The antiepileptic drugs (AEDs) available on the market provide symptomatic relief from epilepsy but do not cure the disease. ...
Cardiac L-type calcium channels and expression of RGK proteins in mouse models associated with type 2 diabetes
(2017-10-19)
Introduction: Cardiovascular disease, such as diabetic cardiomyopathy (DCM) and resulting heart failure (HF), is a leading cause of death for diabetic patients.
In ventricles of non-diabetic HF ...
In ventricles of non-diabetic HF ...
Alk7 signaling and direct lentivirus injection as novel approaches to investigate brown fat development and function
(2017-05-15)
The obesity pandemic is increasing worldwide and is a major threat to human health. Comorbidities associated with obesity are type 2 diabetes, cardiovascular disorders, non-alcoholic fatty liver disease and even some types ...
Enzyme-inhibitory secondary metabolites and their exudation in the marine-derived fungus Epicoccum nigrum link
(2017-04-25)
The kingdom of fungi harbors a huge diversity of life forms. The Ascomycota in particular are a prolific source of medicinal drugs and new lead structures with potent bioactivities. During this work, two marine-derived ......
Feasibility and Efficacy of a Collaborative Medication Management for Elderly, Multimorbid Patients
(2017-08-29)
Medication Review and Medication Management are new pharmaceutical care services with a strong potential to contribute to patients’ health care outcomes. The aim of this work was to evaluate an interprofessional, collaborative ...
A new molecular mechanism to promote protean agonism at a G protein-coupled receptorl
(2017-07-24)
Protean agonists are of great pharmacological interest as their apparent efficacy may change in magnitude and direction depending on the constitutive activity of a receptor. Yet, this intriguing phenomenon has been poorly ...
The orphan G protein-coupled receptor GPR17: its pharmacology and function in recombinant and primary cell expression systems
(2017-04-26)
The reconstitution of myelin sheaths, so called remyelination, represents an innovative therapeutic goal in multiple sclerosis (MS), the most common inflammatory-demyelinating disease of the central nervous system (CNS). ...
Therapeutic concepts: Proposing a new regulatory pathway for combination therapies
(2017-03-24)
Combinations of different medicinal products are widely use in the medical practice and are in fact essential for the treatment of several diseases. The existing regulation for approval of medicinal products offers only a ...
Analysis of the natural product biosynthesis in gliding bacteria using in vitro assays
(2017-01-10)
Natural products are most important in drug discovery and therapy, e.g. more than 80% of antibiotics are derived from microorganisms. Antimicrobial resistance is a global threat and thus an urgent need for new antimicrobial ...