E-Dissertationen: Search
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FR900359, an inhibitor of guanine nucleotide dissociation, effectively blunts signaling of GTPase-deficient Gq: mechanism of action and relevance for treating Gq-driven cancers
(2019-08-01)
Uveal melanoma (UM), the most common cancer of the adult eye, is known to have poor prognosis. Over 50% of patients are likely to develop metastasis. In more than 80% of the cases UM is driven by an activating mutation in ...
Bioinformatische und in-vitro-Analyse der frs-Biosynthesegencluster von Cand. Burkholderia crenata und Chromobacterium vaccinii
(2019-07-03)
FR900359 (FR) ist ein selektiver Gq-Proteininhibitor, der ursprünglich aus der Pflanze Ardisia crenata isoliert wurde. G-Proteine spielen eine zentrale Rolle in der Signalübertragung von G-Protein ......