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Assay Development, Identification, Optimization and Pharmacological Characterization of Inhibitors for Ecto-5′-nucleotidase (CD73)
(2019-10-29)
Extracellular ATP acts as a proinflammatory signaling molecule via G protein-coupled P2Y receptors and ATP-gated P2X ion channel receptors. ATP is hydrolyzed by ecto-nucleotidases: In a first step ecto-nucleoside triphosphate ...