E-Dissertationen: Browsing E-Dissertationen by Classification (DDC) "ddc:500"
Now showing items 21-40 of 58
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Inducing immunity to liver stage malaria through endogenous tissue resident memory cells
(2020-12-16)Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can respond rapidly to infection due to their strategic location. Within the liver, TRM cells can induce effective protection against ... -
Influence of antiviral RNA binding effector proteins on innate immune responses
(2024-08-06)The efficient elimination of viruses is initiated by the recognition of the viral nucleic acid genome or replication intermediates through innate immune receptors. Several different receptors specifically detect double ... -
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ... -
Investigating the Role of Nucleic Acid Sensing in the Pathogenesis of Chronic Viral Infection-Induced Chronic Kidney Disease and Autoimmunity
(2025-02-25)Patients with chronic HIV infections, are at increased risk of developing comorbidities, with chronic kidney disease (CKD) such as immune complex glomerulonephritis (ICGN) being particularly common. Diagnosis of ICGN ... -
Investigation of SECISBP2 mutations and potential viral SECIS element recruitment
(2021-07-15)The 21<sup>st</sup> amino acid selenocysteine (Sec) is encoded by the UGA codon. In order to recode the canonical stop codon additional factors are needed in mammals including the selenocysteine-insertion-sequence (SECIS) ... -
Local synthesis of steroid hormones in human hair roots
(2025-02-17)Hair loss displays a common symptom with a multitude of different origins that complexes diagnostics and therapy. <br /> The basis of the current project was the hypothesis, that hair loss may be correlated or even ... -
Mechanisms underlying the effects of context on food decisions in humans
(2023-05-25)Food decisions are inevitable, frequent, and complex decisions with a high impact on our health. Understanding the mechanisms that underly food decisions has become a multidisciplinary endeavor over the last decades, ... -
Modulation der antibakteriellen Immunantwort in Blut und Aszites durch von Immunzellen produzierten Katecholamine bei Patienten mit Leberzirrhose
(2024-01-05)<strong>Hintergrund und Ziele:</strong> Der Verlauf einer Leberzirrhose mit Aszites kann durch verschiedenste Parameter beeinflusst werden. Im Rahmen der vorliegenden Arbeit wurde untersucht, ob Immunzellen im Blut und / ... -
Modulation of the immune response after myocardial infarction to improve cardiomyocyte engraftment: Inhibition of the NLRP3 inflammasome enhances cell engraftment and preserves cardiac pump function
(2026-03-20)The decline in cardiac pump function due to the formation of a fibrotic scar is one of the most severe consequences of myocardial infarction (MI) and can ultimately result in terminal pump failure of the organ. Currently ... -
Molekularbiologische Untersuchung der Auswirkung einer pharmakologischen Connexin 43-Inhibition auf die Wirksamkeit von Temozolomid beim Glioblastom
(2025-10-01)Glioblastome sind die häufigsten primären Hirntumoren im Erwachsenenalter und trotz multimodaler Therapiekonzepte weiterhin mit einer sehr schlechten Prognose assoziiert. Charakteristisch ist die Ausbildung zellulärer ... -
Molekularpharmakologische Analyse des P2Y12-Rezeptor-Antagonisten Elinogrel
(2025-10-02)Der humane P2Y12-Rezeptor (hP2Y12R) spielt eine Schlüsselrolle bei der Thrombozytenaggregation und ist eine der wichtigsten pharmakologischen Zielstrukturen für klinisch im Rahmen der Prävention und Therapie von thrombotischen ... -
Participation of Ste20-like kinase-deficient neurons in the abnormal circuitry of focal epileptogenic lesions
(2022-01-03)Focal epileptogenic lesions displaying morphologically altered neurons are frequently associated with devastating and therapy-refractory epilepsies. However, it is still unsolved how dysplastic neurons contribute to the ... -
Physical activity and fitness for healthy ageing
(2024-02-19)The proportion of individuals suffering from age-associated noncommunicable diseases is expected to rise rapidly in the next decades. To maintain health, well-being and socioeconomic stability in an ageing society, identifying ... -
Platelets shape the immune response of primary human monocytes
(2023-01-13)Monocytes are circulating immune cells essential to host defense, orchestrating immune responses through the secretion of immunomodulatory mediators. While exuberant monocyte-driven immune responses have life-threatening ... -
Precision and limits of human vision: How visual resolution depends on ocular optics and spatiotemporal sampling characteristics of the foveolar photoreceptor mosaic
(2025-07-11)The human ability to perceive fine spatial details, known as visual resolution, requires combined capacities of both the eye and the brain. Research in anatomy, physiology, and psychophysics has extensively studied the ... -
Retrospektive Kohortenanalyse fortgeschrittener HNO-Tumore am Universitätsklinikum Bonn
(2019-11-13)Kopf-Hals-Tumore stellen weltweit eine führende Rolle in der tumorbedingten Sterblichkeit dar. Kopf-Hals-Tumore sind eine sehr heterogene Gruppe von Tumorentitäten. Gesamtzahlen beziehen sich meist auf Schätzungen oder auf ... -
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations: The establishment of translating ribosome affinity purification
(2020-11-04)Recoding of in-frame UGA/Seccodon in selenoproteins requires a complex translational machinery. The core of this event is the interaction between selenocysteine insertion sequence (SECIS element) in the 3’UTR of ... -
Risikofaktoren für eine akute Hepatitis C-Infektion in der europäischen PROBE-C Studie
(2020-10-14)Ausbrüche von akuten HCV-Infektionen bei HIV-positiven MSM wurden seit 2000 berichtet. Diverse Studien haben die HCV-Infektion mit einer HIV-1-Co-Infektion assoziiert. Bisherige Forschung hat gezeigt, dass Übertragungs-Cluster ... -
The role of CH25H in adipose tissue - a new potential target in anti-obesity therapy?
(2024-06-25)Obesity associates with comorbidities as hypertension, cardiovascular disease, metabolic syndrome and type 2 diabetes mellitus and therefore depicts an emerging health issue. On a molecular level, obesity is accompanied ... -
The role of cytohesins in the regulation of immune responses
(2020-02-17)Cytohesins are guanine nucleotide exchange factors for adenosine diphosphate ribosylation factor (Arf) proteins and promote the switch of Arfs to the active GTP-bound form. Cytohesins have been shown in different <em>in ...
