E-Dissertationen: Search
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Biologika in der Therapie der juvenilen idiopathischen Arthritis: Eine Risikoanalyse
(2022-01-24)
Einleitung
Der Einsatz von Biologika zur Behandlung der juvenilen idiopathischen Arthritis geht mit spezifischen Risiken im Hinblick auf potentielle Nebenwirkungen einher. Ziel dieser Arbeit war es, die ...
Inducing immunity to liver stage malaria through endogenous tissue resident memory cells
(2020-12-16)
Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can respond rapidly to infection due to their strategic location. Within the liver, TRM cells can induce effective protection against ...
Nanoparticle delivery of molecular agents to tackle HIV latency
(2022-09-16)
Antiretroviral therapy (ART) effectively suppresses HIV replication in people living with HIV (PLWH), but treatment is lifelong. The persistence of long-lived, latently infected resting CD4+T cells is a significant ...
Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
(2021-07-13)
Parkinson’s disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation and oxidative damage. Soluble polysialic acid ...
Lipid droplet formation drives pathogenic ILC2 responses in airway inflammation
(2020-06-08)
The Western world is affected by a dramatic increase of chronic inflammatory diseases like asthma, Crohn’s disease and psoriasis. Innate lymphoid cells (ILC) play an important role in the control and maintenance of barrier ...
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Contribution of SIGLEC-11 and SIGLEC-16 receptors to neuro-inflammation and neurodegeneration
(2023-02-14)
Brain aging is a multifactorial process including accumulation of aged lipids and proteins,
neuroinflammation and loss of neurons. SIGLEC-11 and SIGLEC-16 are paired opposite inhibitory- versus activatory-signaling ...
Determining the epigenetic synergy of a repurposed drug and identification of prognosis-related lncRNAs in liver cancer and hematologic malignancies
(2023-11-02)
Background: Epigenetics is crucial in cancer research, revealing its impact on diverse cancer types' development and progression. Epigenetic-targeting drugs show promise in improving patient outcomes, but ...
Control of pulmonary immunity by physical exercise
(2024-03-06)
Sedentary lifestyles combined with high caloric nutrition are widely known to severely contribute to the rise of metabolic diseases like diabetes, atherosclerosis, or obesity in recent years. While endurance training has ......
Die Rolle von Fraktalkin in der Aristolochiasäure-induzierten Nephropathie
(2024-08-12)
Die Fraktalkin (CX3CL1/R1) Achse spielt eine bedeutende Rolle in der Rekrutierung von Immunzellen in verschiedenste Organe. In dieser Arbeit untersuchten wir die Rolle von CX3CR1 exprimierenden Immunzellen in der ...
