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Biologika in der Therapie der juvenilen idiopathischen Arthritis: Eine Risikoanalyse

Thiele, Franz Maria Wilhelm (2022-01-24)

Einleitung Der Einsatz von Biologika zur Behandlung der juvenilen idiopathischen Arthritis geht mit spezifischen Risiken im Hinblick auf potentielle Nebenwirkungen einher. Ziel dieser Arbeit war es, die ...

Inducing immunity to liver stage malaria through endogenous tissue resident memory cells

Valencia Hernandez, Ana Maria (2020-12-16)

Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can respond rapidly to infection due to their strategic location. Within the liver, TRM cells can induce effective protection against ...

Nanoparticle delivery of molecular agents to tackle HIV latency

Ali, Abdalla Abbas Jafer (2022-09-16)

Antiretroviral therapy (ART) effectively suppresses HIV replication in people living with HIV (PLWH), but treatment is lifelong. The persistence of long-lived, latently infected resting CD4⁺T cells is a significant ...

Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice

Liao, Huan (2021-07-13)

Parkinson’s disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation and oxidative damage. Soluble polysialic acid ...

Opioide im Vergleich: Effektivität und Sicherheit von Oxycodon und Piritramid zur Analgesie bei Mittelohreingriffen

Blumberg, Silke Barbara (2021-10-18)

Hintergrund: Eine rein intravenöse Opioidtherapie ist mit zusätzlichem Material-, Organisations-, Personal- und Ressourcenaufwand sowie einem erhöhtem Risiko an Nebenwirkungen und potenziell notwendigen ...

Lipid droplet formation drives pathogenic ILC2 responses in airway inflammation

Kharabi Masouleh, Schekufe (2020-06-08)

The Western world is affected by a dramatic increase of chronic inflammatory diseases like asthma, Crohn’s disease and psoriasis. Innate lymphoid cells (ILC) play an important role in the control and maintenance of barrier ...

Nucleic acid sensing in CD4 T cells during HIV-1 and other viral infections

Holz, Marvin (2021-10-15)

Viruses are small intracellular parasites and use the host cell’s biosynthesis machinery to replicate and spread. Therefore, viral particles incorporate structures that are similar to the ones that naturally occur within ...

RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection

Marx, Samira Alina (2022-07-08)

The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...

Einfluss der Cyclin-abhängigen Kinase 5 auf die Expression des Programmed Cell Death Ligand 1 in murinen Pankreaskarzinomen im Vergleich verschiedener Analysemethoden

Mann, Marcel (2023-03-23)

Einleitung: Programmed Cell Death Ligand 1 (PD-L1) ist ein immuninhibitorisches Molekül, das für gewöhnlich von bestimmten Immunzellen oder dendritischen Zellen exprimiert wird. Auch verschiedene Tumoren ...

Contribution of SIGLEC-11 and SIGLEC-16 receptors to neuro-inflammation and neurodegeneration

Afrang, Negin (2023-02-14)

Brain aging is a multifactorial process including accumulation of aged lipids and proteins, neuroinflammation and loss of neurons. SIGLEC-11 and SIGLEC-16 are paired opposite inhibitory- versus activatory-signaling ...