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Interplay of IKKs and IKK-related kinases in antiviral nucleic acid receptor signaling in human monocytes
(2022-06-21)
Monocytes and monocyte-derived cells are among the first line of host defense against
invading pathogens. They are equipped with pattern recognition receptors (PRRs) that
detect conserved components of microbes and in ...
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)
Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ......