Cytosolic sensor proteins like NLRP1 (NOD-like receptor containing a pyrin domain 1) play a fundamental role in mediating innate immunity. Upon activation they form signalling hubs that recruit the adaptor protein ASC ...

Monocytes are circulating immune cells essential to host defense, orchestrating immune responses through the secretion of immunomodulatory mediators. While exuberant monocyte-driven immune responses have life-threatening ...

The primary cilium is a cellular antenna that senses and integrates external stimuli. Its composition is regulated by specialized proteins, such as BBS proteins, and mutations in any of the genes that encode BBS proteins ...

TNIP1 is a protein associated with autophagy and inflammation, which is ubiquitously expressed in the brain. It mediates extracellular signals such as growth factor signaling, influences nuclear expression patterns driven ...